STRINGSTRING
DLL4 DLL4 WNT6 WNT6 WNT11 WNT11 WNT3A WNT3A MAPK1 MAPK1 WNT9B WNT9B WNT3 WNT3 FZD9 FZD9 WNT4 WNT4 NCOA3 NCOA3 LOC102747801 LOC102747801 DLL1 DLL1 CCND1 CCND1 FGF17 FGF17 LOC102731813 LOC102731813 LOC102737823 LOC102737823 FGF3 FGF3 FGF4 FGF4 FGF18 FGF18 PIK3CD PIK3CD FOS FOS LOC102733219 LOC102733219 LOC102726140 LOC102726140 HEYL HEYL PIK3CA PIK3CA LOC102737030 LOC102737030 FZD4 FZD4 GADD45G GADD45G LOC102736516 LOC102736516 ESR2 ESR2 E2F3 E2F3 FGF21 FGF21 NCOA7 NCOA7 LOC102739552 LOC102739552 NOTCH2 NOTCH2 LOC102750211 LOC102750211 LOC102732238 LOC102732238 WNT2B WNT2B GADD45B GADD45B HEY2 HEY2 LOC102731850 LOC102731850 FGF6 FGF6 FGF23 FGF23 FGF2 FGF2 LOC102729504 LOC102729504 LOC102750316 LOC102750316 LOC102739775 LOC102739775 FGF22 FGF22 LOC102744822 LOC102744822 CDKN1A CDKN1A NFKB2 NFKB2 RPS6KB2 RPS6KB2 LOC102744110 LOC102744110 LOC102726484 LOC102726484 LOC102742177 LOC102742177 WNT10B WNT10B FGF8 FGF8 PGR PGR DDB2 DDB2 MAP2K1 MAP2K1 FGF10 FGF10 WNT1 WNT1 PIK3R3 PIK3R3 BRCA2 BRCA2 CSDE1 CSDE1 NRAS NRAS WNT16 WNT16 LOC102726446 LOC102726446 FGF9 FGF9 KRAS KRAS FGF20 FGF20 JUN JUN LEF1 LEF1 FGF16 FGF16 LOC102751021 LOC102751021 DVL2 DVL2 TP53 TP53 TCF7L1 TCF7L1 MAP2K2 MAP2K2 FRAT1 FRAT1 ERAS ERAS AKT1 AKT1 IGF1R IGF1R DVL3 DVL3 BAK1 BAK1 E2F2 E2F2 FGF5 FGF5 LOC102745156 LOC102745156 WNT8A WNT8A JAG1 JAG1 CEP152 CEP152 SHC4 SHC4 NOTCH4 NOTCH4 GPSM3 GPSM3 FZD2 FZD2 GALK2 GALK2 FGF7 FGF7 MTOR MTOR LOC102745454 LOC102745454 GADD45A GADD45A FZD3 FZD3 SHC1 SHC1 FZD7 FZD7 FZD5 FZD5 LRP6 LRP6 PTEN PTEN LOC102737670 LOC102737670 DVL1 DVL1 AXIN1 AXIN1 IGF1 IGF1 LOC102749673 LOC102749673 AKT3 AKT3 CDK4 CDK4 FZD10 FZD10 RAF1 RAF1 RPS6KB1 RPS6KB1 RB1 RB1 CSNK1A1 CSNK1A1 WNT5A WNT5A NCOA1 NCOA1 SP1 SP1 GSK3B GSK3B WNT5B WNT5B WNT10A WNT10A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (218 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (407 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (296 aa)
NCOA3Nuclear receptor coactivator 3-like. (1154 aa)
LOC102747801Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (214 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
LOC102731813Frizzled-6-like; Belongs to the G-protein coupled receptor Fz/Smo family. (400 aa)
LOC102737823Fibroblast growth factor 19-like; Belongs to the heparin-binding growth factors family. (115 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (200 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (172 aa)
FGF18Fibroblast growth factor 18. (116 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
LOC102733219Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (147 aa)
LOC102726140Frizzled-1-like; Belongs to the G-protein coupled receptor Fz/Smo family. (647 aa)
HEYLHairy/enhancer-of-split related with YRPW motif-like protein. (328 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC102737030Receptor tyrosine-protein kinase erbB-2-like; Belongs to the protein kinase superfamily. Tyr protein kinase family. (627 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
ESR2Estrogen receptor beta. (429 aa)
E2F3Transcription factor E2F3-like isoform X1. (465 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
NCOA7Nuclear receptor coactivator 7-like isoform X1. (943 aa)
LOC102739552Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
NOTCH2Neurogenic locus notch homolog protein 2. (1238 aa)
LOC102750211Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (154 aa)
LOC102732238Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (265 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta isoform X2. (160 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2-like. (337 aa)
LOC102731850Tyrosine-protein kinase receptor. (757 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (182 aa)
FGF23Fibroblast growth factor 23. (177 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
LOC102729504Apoptosis regulator BAX-like. (212 aa)
LOC102750316Hairy/enhancer-of-split related with YRPW motif protein 1-like isoform X2. (304 aa)
LOC102739775Breast cancer type 1 susceptibility protein homolog. (471 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
LOC102744822Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...] (56 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (161 aa)
NFKB2Nuclear factor NF-kappa-B p100 subunit. (900 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
LOC102744110Tumor necrosis factor ligand superfamily member 11-like; Belongs to the tumor necrosis factor family. (188 aa)
LOC102726484Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (207 aa)
LOC102742177Mast/stem cell growth factor receptor Kit-like. (217 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (140 aa)
PGRProgesterone receptor. (827 aa)
DDB2DNA damage-binding protein 2 isoform X1. (426 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
BRCA2Breast cancer type 2 susceptibility protein homolog. (2818 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (845 aa)
NRASGTPase NRas. (189 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (149 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
KRASGTPase KRas isoform X2. (188 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (335 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2 isoform X1. (734 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
TCF7L1Transcription factor 7-like 1. (438 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
FRAT1Proto-oncogene FRAT1. (168 aa)
ERASGTPase ERas. (233 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
IGF1RInsulin-like growth factor 1 receptor-like. (291 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (716 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
E2F2Transcription factor E2F2. (440 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (275 aa)
LOC102745156Catenin beta-1-like isoform X1. (216 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
CEP152Centrosomal protein of 152 kDa isoform X1. (1723 aa)
SHC4SHC-transforming protein 4. (630 aa)
NOTCH4Neurogenic locus notch homolog protein 4 isoform X1. (1996 aa)
GPSM3G-protein-signaling modulator 3 isoform X1. (162 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
GALK2N-acetylgalactosamine kinase. (332 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
LOC102745454Nuclear receptor coactivator 3-like. (176 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
FZD3Frizzled-3 isoform X2; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
SHC1SHC-transforming protein 1 isoform X2. (583 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
LOC102737670Cyclin-dependent kinase 6-like. (322 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (693 aa)
AXIN1Axin-1 isoform X1. (867 aa)
IGF1Insulin-like growth factor I isoform X1. (153 aa)
LOC102749673Insulin-like growth factor 1 receptor-like. (143 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
RPS6KB1Non-specific serine/threonine protein kinase. (445 aa)
RB1Retinoblastoma-associated protein. (846 aa)
CSNK1A1Casein kinase I isoform alpha; Belongs to the protein kinase superfamily. (227 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
SP1Transcription factor Sp1 isoform X1. (786 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (261 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
Server load: low (30%) [HD]