STRINGSTRING
ARID2 ARID2 ERAS ERAS AKT1 AKT1 IGF1R IGF1R TGFB2 TGFB2 DVL3 DVL3 BAK1 BAK1 E2F2 E2F2 LOC102745156 LOC102745156 WNT8A WNT8A CEP152 CEP152 SHC4 SHC4 SMARCA2 SMARCA2 FZD2 FZD2 MTOR MTOR GADD45A GADD45A FZD3 FZD3 GAB1 GAB1 SHC1 SHC1 SMAD4 SMAD4 FZD7 FZD7 ACTB ACTB TGFBR2 TGFBR2 ACTL6B ACTL6B FZD5 FZD5 LRP6 LRP6 PTEN PTEN LOC102737670 LOC102737670 DVL1 DVL1 AXIN1 AXIN1 DDB2 DDB2 MAP2K1 MAP2K1 WNT1 WNT1 PIK3R3 PIK3R3 CSDE1 CSDE1 NRAS NRAS TGFA TGFA WNT16 WNT16 LOC102726446 LOC102726446 KRAS KRAS BCL2L1 BCL2L1 LEF1 LEF1 HGF HGF ACTG1 ACTG1 LOC102748841 LOC102748841 LOC102751021 LOC102751021 WNT10B WNT10B LOC102726484 LOC102726484 RPS6KB2 RPS6KB2 CDKN1A CDKN1A IGF2 IGF2 DPF1 DPF1 LOC102729504 LOC102729504 LOC102730318 LOC102730318 LOC102731850 LOC102731850 GADD45B GADD45B WNT2B WNT2B LOC102732238 LOC102732238 TXNRD2 TXNRD2 LOC102747537 LOC102747537 LOC102750211 LOC102750211 LOC102739552 LOC102739552 ACTL8 ACTL8 TGFB3 TGFB3 TGFB1 TGFB1 E2F3 E2F3 LOC102736516 LOC102736516 GADD45G GADD45G FZD4 FZD4 NFE2L2 NFE2L2 LOC102740820 LOC102740820 LOC102740522 LOC102740522 ACTL6A ACTL6A PIK3CA PIK3CA LOC102726140 LOC102726140 PIK3CD PIK3CD SMARCE1 SMARCE1 LOC102731813 LOC102731813 CCND1 CCND1 WNT4 WNT4 LOC102729978 LOC102729978 GSTO1 GSTO1 LOC102735415 LOC102735415 PBRM1 PBRM1 FZD9 FZD9 WNT3 WNT3 WNT9B WNT9B LOC102730785 LOC102730785 MAPK1 MAPK1 WNT3A WNT3A WNT11 WNT11 MGST2 MGST2 GSTM3 GSTM3 WNT6 WNT6 WNT10A WNT10A GSTM1 GSTM1 SMARCD3 SMARCD3 WNT5B WNT5B GSK3B GSK3B MGST3 MGST3 WNT5A WNT5A KEAP1 KEAP1 LOC102744859 LOC102744859 CSNK1A1 CSNK1A1 RB1 RB1 RPS6KB1 RPS6KB1 RAF1 RAF1 FZD10 FZD10 CDK4 CDK4 AKT3 AKT3 LOC102749673 LOC102749673 ARID1A ARID1A DVL2 DVL2 TP53 TP53 TCF7L1 TCF7L1 MAP2K2 MAP2K2 LOC102730764 LOC102730764 MGST1 MGST1 FRAT1 FRAT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARID2AT-rich interactive domain-containing protein 2. (1836 aa)
ERASGTPase ERas. (233 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
IGF1RInsulin-like growth factor 1 receptor-like. (291 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (716 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
E2F2Transcription factor E2F2. (440 aa)
LOC102745156Catenin beta-1-like isoform X1. (216 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
CEP152Centrosomal protein of 152 kDa isoform X1. (1723 aa)
SHC4SHC-transforming protein 4. (630 aa)
SMARCA2Probable global transcription activator SNF2L2 isoform X1. (278 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
FZD3Frizzled-3 isoform X2; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (724 aa)
SHC1SHC-transforming protein 1 isoform X2. (583 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
ACTBActin, cytoplasmic 1. (375 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (564 aa)
ACTL6BActin-like protein 6B. (130 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
LOC102737670Cyclin-dependent kinase 6-like. (322 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (693 aa)
AXIN1Axin-1 isoform X1. (867 aa)
DDB2DNA damage-binding protein 2 isoform X1. (426 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (845 aa)
NRASGTPase NRas. (189 aa)
TGFAProtransforming growth factor alpha. (160 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (149 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
KRASGTPase KRas isoform X2. (188 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
ACTG1LOW QUALITY PROTEIN: actin, gamma 1. (411 aa)
LOC102748841Actin-like protein 6B-like. (150 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
LOC102726484Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (207 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (161 aa)
IGF2Insulin-like growth factor II. (138 aa)
DPF1Zinc finger protein neuro-d4 isoform X1. (414 aa)
LOC102729504Apoptosis regulator BAX-like. (212 aa)
LOC102730318Mothers against decapentaplegic homolog. (415 aa)
LOC102731850Tyrosine-protein kinase receptor. (757 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta isoform X2. (160 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
LOC102732238Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (265 aa)
TXNRD2Thioredoxin reductase 2, mitochondrial. (425 aa)
LOC102747537Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (549 aa)
LOC102750211Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (154 aa)
LOC102739552Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
ACTL8Actin-like protein 8; Belongs to the actin family. (366 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
TGFB1Transforming growth factor beta-1. (261 aa)
E2F3Transcription factor E2F3-like isoform X1. (465 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2 isoform X1. (590 aa)
LOC102740820Glutathione S-transferase theta-1-like; Belongs to the GST superfamily. (240 aa)
LOC102740522Glutathione S-transferase theta-1-like; Belongs to the GST superfamily. (242 aa)
ACTL6AActin-like protein 6A isoform X1; Belongs to the actin family. (429 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC102726140Frizzled-1-like; Belongs to the G-protein coupled receptor Fz/Smo family. (647 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
SMARCE1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1. (339 aa)
LOC102731813Frizzled-6-like; Belongs to the G-protein coupled receptor Fz/Smo family. (400 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (214 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (296 aa)
LOC102729978Beta-actin-like protein 2-like isoform X1. (376 aa)
GSTO1Glutathione S-transferase omega-1 isoform X1; Belongs to the GST superfamily. (241 aa)
LOC102735415Phosphoinositide phospholipase C. (309 aa)
PBRM1Protein polybromo-1 isoform X1. (1704 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (407 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (218 aa)
LOC102730785Glutathione S-transferase P-like; Belongs to the GST superfamily. (210 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
MGST2Microsomal glutathione S-transferase 2. (146 aa)
GSTM3Glutathione S-transferase. (226 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (261 aa)
GSTM1Glutathione S-transferase Mu 1 isoform X1. (218 aa)
SMARCD3SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3. (435 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
MGST3Microsomal glutathione S-transferase 3 isoform X1. (152 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
KEAP1Kelch-like ECH-associated protein 1. (624 aa)
LOC102744859SWI/SNF complex subunit SMARCC2-like. (344 aa)
CSNK1A1Casein kinase I isoform alpha; Belongs to the protein kinase superfamily. (227 aa)
RB1Retinoblastoma-associated protein. (846 aa)
RPS6KB1Non-specific serine/threonine protein kinase. (445 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
LOC102749673Insulin-like growth factor 1 receptor-like. (143 aa)
ARID1AAT-rich interactive domain-containing protein 1A. (1630 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2 isoform X1. (734 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
TCF7L1Transcription factor 7-like 1. (438 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
LOC102730764Mothers against decapentaplegic homolog 2-like. (227 aa)
MGST1Microsomal glutathione S-transferase 1 isoform X2. (155 aa)
FRAT1Proto-oncogene FRAT1. (168 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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