STRINGSTRING
ERAS ERAS LOC102751021 LOC102751021 MAPK11 MAPK11 LOC102749847 LOC102749847 RPS6KB2 RPS6KB2 PDCD1 PDCD1 TWF2 TWF2 STAT3 STAT3 MYD88 MYD88 NFKBIE NFKBIE LOC102736516 LOC102736516 CD28 CD28 LOC102732223 LOC102732223 MAP2K3 MAP2K3 LOC102725943 LOC102725943 NFATC1 NFATC1 PIK3CA PIK3CA FOS FOS PIK3CD PIK3CD IKBKB IKBKB MAPK1 MAPK1 BATF BATF RASGRP1 RASGRP1 CD3D CD3D LOC102734398 LOC102734398 LOC102730162 LOC102730162 CHUK CHUK MAP3K3 MAP3K3 RPS6KB1 RPS6KB1 RAF1 RAF1 IFNG IFNG AKT3 AKT3 JUN JUN NFKBIB NFKBIB IKBKG IKBKG MAP2K2 MAP2K2 LOC102745161 LOC102745161 HIF1A HIF1A CSNK2B CSNK2B LY6G5B LY6G5B AKT1 AKT1 CD4 CD4 JAK2 JAK2 BATF2 BATF2 TICAM2 TICAM2 TMED7 TMED7 LTK LTK TRAF6 TRAF6 IFNGR2 IFNGR2 PTPN11 PTPN11 CD247 CD247 MTOR MTOR MAPK12 MAPK12 PRKCQ PRKCQ LAT LAT ZAP70 ZAP70 PTEN PTEN NFKB1 NFKB1 NFKBIA NFKBIA MAP2K6 MAP2K6 NFATC3 NFATC3 PPP3R1 PPP3R1 MAP2K1 MAP2K1 LOC102750498 LOC102750498 PIK3R3 PIK3R3 CSDE1 CSDE1 NRAS NRAS LOC102726446 LOC102726446 KRAS KRAS PPP3R2 PPP3R2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ERASGTPase ERas. (233 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
MAPK11Mitogen-activated protein kinase. (254 aa)
LOC102749847Tyrosine-protein kinase JAK1-like. (444 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
PDCD1Programmed cell death protein 1. (266 aa)
TWF2Toll-like receptor 9-like isoform X1. (1331 aa)
STAT3Signal transducer and activator of transcription 3-like. (424 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
NFKBIENF-kappa-B inhibitor epsilon. (361 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
CD28T-cell-specific surface glycoprotein CD28. (209 aa)
LOC102732223Toll/interleukin-1 receptor domain-containing adapter protein-like. (226 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
LOC102725943Nuclear factor of activated T-cells, cytoplasmic 2-like. (160 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (221 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
BATFBasic leucine zipper transcriptional factor ATF-like. (125 aa)
RASGRP1RAS guanyl-releasing protein 1-like isoform X1. (366 aa)
CD3DT-cell surface glycoprotein CD3 delta chain. (171 aa)
LOC102734398T-cell surface glycoprotein CD3 gamma chain-like. (167 aa)
LOC102730162T-cell surface glycoprotein CD3 gamma chain-like. (182 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (600 aa)
RPS6KB1Non-specific serine/threonine protein kinase. (445 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (335 aa)
NFKBIBNF-kappa-B inhibitor beta isoform X2. (354 aa)
IKBKGNF-kappa-B essential modulator isoform X2. (419 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
LOC102745161Signal transducer and activator of transcription 3-like. (301 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
LY6G5BLymphocyte antigen 6 complex locus protein G5b. (195 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
CD4T-cell surface glycoprotein CD4. (462 aa)
JAK2Tyrosine-protein kinase. (952 aa)
BATF2Basic leucine zipper transcriptional factor ATF-like 2. (275 aa)
TICAM2TIR domain-containing adapter molecule 2. (238 aa)
TMED7Transmembrane emp24 domain-containing protein 7. (224 aa)
LTKLOW QUALITY PROTEIN: leukocyte tyrosine kinase receptor. (841 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
IFNGR2Interferon gamma receptor 2. (115 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
CD247T-cell surface glycoprotein CD3 zeta chain. (166 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
LATLinker for activation of T-cells family member 1. (256 aa)
ZAP70Tyrosine-protein kinase. (616 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
NFKBIANF-kappa-B inhibitor alpha isoform X2. (314 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1075 aa)
PPP3R1Calcineurin subunit B type 1 isoform X1. (170 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
LOC102750498Casein kinase II subunit alpha-like isoform X1; Belongs to the protein kinase superfamily. (391 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (845 aa)
NRASGTPase NRas. (189 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
KRASGTPase KRas isoform X2. (188 aa)
PPP3R2Calcineurin subunit B type 2. (170 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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