47 items (Leptonychotes weddellii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RORC	Nuclear receptor ROR-gamma isoform X1. (518 aa)
	NFKB1	Nuclear factor NF-kappa-B p105 subunit. (254 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	IL10	Interleukin-10. (178 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (131 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
	IL13	Interleukin-13. (133 aa)
	IL23R	Interleukin-23 receptor. (631 aa)
	IL12RB2	Interleukin-12 receptor subunit beta-2. (851 aa)
	LOC102740784	HLA class II histocompatibility antigen, DR alpha chain-like; Belongs to the MHC class II family. (254 aa)
	LOC102741082	DLA class II histocompatibility antigen, DR-1 beta chain-like. (266 aa)
	IFNGR2	Interferon gamma receptor 2. (115 aa)
	IL18R1	Interleukin-18 receptor 1. (540 aa)
	IL18RAP	Interleukin-18 receptor accessory protein. (593 aa)
	LOC102748462	HLA class II histocompatibility antigen, DO beta chain-like. (273 aa)
	LOC102750454	HLA class II histocompatibility antigen, DM alpha chain-like; Belongs to the MHC class II family. (261 aa)
	LOC102750166	HLA class II histocompatibility antigen, DM beta chain-like. (263 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (153 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	LOC102745161	Signal transducer and activator of transcription 3-like. (301 aa)
	LOC102730764	Mothers against decapentaplegic homolog 2-like. (227 aa)
	JUN	Transcription factor AP-1; Belongs to the bZIP family. (335 aa)
	IL22	Interleukin-22 isoform X1. (179 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	IL23A	Interleukin-23 subunit alpha. (210 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (279 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
	NOD2	Nucleotide-binding oligomerization domain-containing protein 2. (1013 aa)
	IL6	Interleukin-6 isoform X1. (212 aa)
	FOXP3	Forkhead box protein P3 isoform X1. (456 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
	IL1A	Interleukin-1; Belongs to the IL-1 family. (265 aa)
	TBX21	T-box transcription factor TBX21. (535 aa)
	NFATC1	Nuclear factor of activated T-cells, cytoplasmic 1. (221 aa)
	IL21R	Interleukin-21 receptor. (542 aa)
	TGFB1	Transforming growth factor beta-1. (261 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	IL17A	interleukin-17A. (155 aa)
	IL17F	interleukin-17F. (157 aa)
	IL4R	Interleukin-4 receptor subunit alpha isoform X1. (797 aa)
	LOC102730318	Mothers against decapentaplegic homolog. (415 aa)
	LOC102734456	HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family. (250 aa)
	STAT3	Signal transducer and activator of transcription 3-like. (424 aa)
	TLR5	LOW QUALITY PROTEIN: toll-like receptor 5; Belongs to the Toll-like receptor family. (834 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FOXP3	GATA3	A0A2U3YH69	A0A2U3YCA3	Forkhead box protein P3 isoform X1.	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	0.793
FOXP3	IFNG	A0A2U3YH69	A0A2U3Y8N2	Forkhead box protein P3 isoform X1.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.938
FOXP3	IL10	A0A2U3YH69	A0A2U3XRS9	Forkhead box protein P3 isoform X1.	Interleukin-10.	0.813
FOXP3	IL13	A0A2U3YH69	A0A2U3XTH0	Forkhead box protein P3 isoform X1.	Interleukin-13.	0.657
FOXP3	IL17A	A0A2U3YH69	A0A2U3YYK4	Forkhead box protein P3 isoform X1.	interleukin-17A.	0.773
FOXP3	IL17F	A0A2U3YH69	A0A2U3YYK8	Forkhead box protein P3 isoform X1.	interleukin-17F.	0.607
FOXP3	IL18	A0A2U3YH69	A0A2U3XPG8	Forkhead box protein P3 isoform X1.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.505
FOXP3	IL1A	A0A2U3YH69	A0A2U3YMJ2	Forkhead box protein P3 isoform X1.	Interleukin-1; Belongs to the IL-1 family.	0.414
FOXP3	IL1B	A0A2U3YH69	A0A2U3YM52	Forkhead box protein P3 isoform X1.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.605
FOXP3	IL2	A0A2U3YH69	A0A2U3Y3E4	Forkhead box protein P3 isoform X1.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.908
FOXP3	IL21	A0A2U3YH69	A0A2U3Y3E7	Forkhead box protein P3 isoform X1.	Interleukin; Belongs to the IL-15/IL-21 family.	0.738
FOXP3	IL21R	A0A2U3YH69	A0A2U3YST0	Forkhead box protein P3 isoform X1.	Interleukin-21 receptor.	0.768
FOXP3	IL22	A0A2U3YH69	A0A2U3Y8K1	Forkhead box protein P3 isoform X1.	Interleukin-22 isoform X1.	0.613
FOXP3	IL23R	A0A2U3YH69	A0A2U3XVK3	Forkhead box protein P3 isoform X1.	Interleukin-23 receptor.	0.505
FOXP3	IL4	A0A2U3YH69	A0A2U3XTG1	Forkhead box protein P3 isoform X1.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.752
FOXP3	IL5	A0A2U3YH69	A0A2U3XTG3	Forkhead box protein P3 isoform X1.	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells.	0.639
FOXP3	IL6	A0A2U3YH69	A0A2U3YGL7	Forkhead box protein P3 isoform X1.	Interleukin-6 isoform X1.	0.750
FOXP3	JUN	A0A2U3YH69	A0A2U3Y748	Forkhead box protein P3 isoform X1.	Transcription factor AP-1; Belongs to the bZIP family.	0.425
FOXP3	LOC102730318	A0A2U3YH69	A0A2U3Z2G6	Forkhead box protein P3 isoform X1.	Mothers against decapentaplegic homolog.	0.641
FOXP3	LOC102730764	A0A2U3YH69	A0A2U3Y552	Forkhead box protein P3 isoform X1.	Mothers against decapentaplegic homolog 2-like.	0.602