(20 nodes) Primary immunodeficiency network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CD79A	B-cell antigen receptor complex-associated protein alpha chain isoform X1. (236 aa)
	ZAP70	Tyrosine-protein kinase. (616 aa)
	CD19	B-lymphocyte antigen CD19. (559 aa)
	RAG2	V(D)J recombination-activating protein 2. (527 aa)
	RAG1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
	BTK	Tyrosine-protein kinase. (659 aa)
	CD4	T-cell surface glycoprotein CD4. (462 aa)
	TAP1	Antigen peptide transporter 1. (750 aa)
	IKBKG	NF-kappa-B essential modulator isoform X2. (419 aa)
	CD40	Tumor necrosis factor receptor superfamily member 5. (272 aa)
	CD8A	T-cell surface glycoprotein CD8 alpha chain. (213 aa)
	CD3D	T-cell surface glycoprotein CD3 delta chain. (171 aa)
	RFXANK	DNA-binding protein RFXANK. (260 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
	LOC102727257	Tumor necrosis factor receptor superfamily member 13B-like. (270 aa)
	ICOS	Inducible T-cell costimulator. (209 aa)
	ORAI1	Calcium release-activated calcium channel protein 1. (302 aa)
	JAK3	Tyrosine-protein kinase. (1139 aa)
	LOC102732741	uracil-DNA glycosylase-like. (177 aa)
	LOC102733853	Antigen peptide transporter 2-like. (411 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTK	CD19	A0A2U3Y201	A0A2U3XRD6	Tyrosine-protein kinase.	B-lymphocyte antigen CD19.	0.703
BTK	CD3D	A0A2U3Y201	A0A2U3YDJ4	Tyrosine-protein kinase.	T-cell surface glycoprotein CD3 delta chain.	0.438
BTK	CD40	A0A2U3Y201	A0A2U3Y7Z8	Tyrosine-protein kinase.	Tumor necrosis factor receptor superfamily member 5.	0.508
BTK	CD40LG	A0A2U3Y201	A0A2U3YMY4	Tyrosine-protein kinase.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.516
BTK	CD79A	A0A2U3Y201	A0A2U3XL31	Tyrosine-protein kinase.	B-cell antigen receptor complex-associated protein alpha chain isoform X1.	0.709
BTK	CD8A	A0A2U3Y201	A0A2U3YBZ1	Tyrosine-protein kinase.	T-cell surface glycoprotein CD8 alpha chain.	0.420
BTK	IKBKG	A0A2U3Y201	A0A2U3Y6Q4	Tyrosine-protein kinase.	NF-kappa-B essential modulator isoform X2.	0.909
BTK	RAG2	A0A2U3Y201	A0A2U3XYU9	Tyrosine-protein kinase.	V(D)J recombination-activating protein 2.	0.539
BTK	ZAP70	A0A2U3Y201	A0A2U3XR38	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.714
CD19	BTK	A0A2U3XRD6	A0A2U3Y201	B-lymphocyte antigen CD19.	Tyrosine-protein kinase.	0.703
CD19	CD4	A0A2U3XRD6	A0A2U3Y2Q1	B-lymphocyte antigen CD19.	T-cell surface glycoprotein CD4.	0.845
CD19	CD40	A0A2U3XRD6	A0A2U3Y7Z8	B-lymphocyte antigen CD19.	Tumor necrosis factor receptor superfamily member 5.	0.881
CD19	CD40LG	A0A2U3XRD6	A0A2U3YMY4	B-lymphocyte antigen CD19.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.798
CD19	CD79A	A0A2U3XRD6	A0A2U3XL31	B-lymphocyte antigen CD19.	B-cell antigen receptor complex-associated protein alpha chain isoform X1.	0.965
CD19	CD8A	A0A2U3XRD6	A0A2U3YBZ1	B-lymphocyte antigen CD19.	T-cell surface glycoprotein CD8 alpha chain.	0.671
CD19	ICOS	A0A2U3XRD6	A0A2U3YTM1	B-lymphocyte antigen CD19.	Inducible T-cell costimulator.	0.773
CD19	RAG1	A0A2U3XRD6	A0A2U3XZ32	B-lymphocyte antigen CD19.	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...]	0.840
CD19	RAG2	A0A2U3XRD6	A0A2U3XYU9	B-lymphocyte antigen CD19.	V(D)J recombination-activating protein 2.	0.769
CD19	ZAP70	A0A2U3XRD6	A0A2U3XR38	B-lymphocyte antigen CD19.	Tyrosine-protein kinase.	0.797
CD3D	BTK	A0A2U3YDJ4	A0A2U3Y201	T-cell surface glycoprotein CD3 delta chain.	Tyrosine-protein kinase.	0.438