STRINGSTRING
LOC102727336 LOC102727336 ITGA5 ITGA5 ITGA7 ITGA7 CACNB3 CACNB3 ADCY6 ADCY6 CACNG5 CACNG5 CACNG1 CACNG1 CACNG4 CACNG4 ITGA10 ITGA10 LOC102727373 LOC102727373 SGCD SGCD IGF1 IGF1 TNNC1 TNNC1 LOC102743063 LOC102743063 ACTB ACTB ITGB3 ITGB3 SLC8A3 SLC8A3 CACNB2 CACNB2 PRKACB PRKACB MYL2 MYL2 CACNG7 CACNG7 CACNG6 CACNG6 ITGB1 ITGB1 TGFB2 TGFB2 CACNA1F CACNA1F TNF TNF LOC102749767 LOC102749767 LRRC66 LRRC66 SGCB SGCB DES DES LOC102744445 LOC102744445 SGCA SGCA ITGA4 ITGA4 LOC102739404 LOC102739404 ITGA9 ITGA9 PTRHD1 PTRHD1 PLN PLN ITGB7 ITGB7 LOC102731583 LOC102731583 TNNI3 TNNI3 CACNA2D4 CACNA2D4 LOC102742813 LOC102742813 CACNB1 CACNB1 TPM3 TPM3 LOC102729978 LOC102729978 DAG1 DAG1 ADCY9 ADCY9 MYH3 MYH3 LOC102741220 LOC102741220 LOC102746012 LOC102746012 LOC102745190 LOC102745190 CACNG2 CACNG2 ATP2A3 ATP2A3 TPM2 TPM2 TGFB1 TGFB1 TGFB3 TGFB3 ACTL8 ACTL8 LOC102744274 LOC102744274 TNNT3 TNNT3 AGT AGT SLC39A12 SLC39A12 TPM4 TPM4 PRKACA PRKACA LMNA LMNA EMD EMD LOC102731038 LOC102731038 LOC102730020 LOC102730020 LOC102749357 LOC102749357 LOC102749446 LOC102749446 LOC102726696 LOC102726696 LOC102740174 LOC102740174 ACTG1 ACTG1 SLC8A1 SLC8A1 CACNA2D1 CACNA2D1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102727336Voltage-dependent calcium channel subunit alpha-2/delta-3-like. (239 aa)
ITGA5Integrin alpha-5; Belongs to the integrin alpha chain family. (1054 aa)
ITGA7Integrin alpha-7; Belongs to the integrin alpha chain family. (1181 aa)
CACNB3Voltage-dependent L-type calcium channel subunit beta-3 isoform X1. (484 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
CACNG5Voltage-dependent calcium channel gamma-5 subunit. (275 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (224 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
ITGA10LOW QUALITY PROTEIN: integrin alpha-10; Belongs to the integrin alpha chain family. (1165 aa)
LOC102727373Integrin alpha-10-like. (374 aa)
SGCDDelta-sarcoglycan. (122 aa)
IGF1Insulin-like growth factor I isoform X1. (153 aa)
TNNC1Troponin C, slow skeletal and cardiac muscles. (161 aa)
LOC102743063Delta-sarcoglycan-like. (113 aa)
ACTBActin, cytoplasmic 1. (375 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (852 aa)
SLC8A3Sodium/calcium exchanger 3 isoform X3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (922 aa)
CACNB2Voltage-dependent L-type calcium channel subunit beta-2 isoform X1. (613 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1. (166 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (260 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1983 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC102749767Integrin alpha-IIb-like. (534 aa)
LRRC66Leucine-rich repeat-containing protein 66. (1019 aa)
SGCBBeta-sarcoglycan. (393 aa)
DESDesmin; Belongs to the intermediate filament family. (470 aa)
LOC102744445Integrin beta; Belongs to the integrin beta chain family. (197 aa)
SGCAAlpha-sarcoglycan. (386 aa)
ITGA4Integrin alpha-4; Belongs to the integrin alpha chain family. (1033 aa)
LOC102739404Integrin alpha-9-like. (152 aa)
ITGA9Integrin alpha-9-like. (470 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (763 aa)
LOC102731583Voltage-dependent calcium channel gamma-3 subunit-like. (315 aa)
TNNI3Troponin I, cardiac muscle isoform X1. (211 aa)
CACNA2D4Voltage-dependent calcium channel subunit alpha-2/delta-4. (1102 aa)
LOC102742813Neuroendocrine secretory protein 55-like. (246 aa)
CACNB1Voltage-dependent L-type calcium channel subunit beta-1 isoform X1. (643 aa)
TPM3Tropomyosin alpha-3 chain isoform X1; Belongs to the tropomyosin family. (285 aa)
LOC102729978Beta-actin-like protein 2-like isoform X1. (376 aa)
DAG1Dystroglycan isoform X1. (891 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (790 aa)
MYH3Myosin-3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1940 aa)
LOC102741220Integrin alpha-9-like. (114 aa)
LOC102746012Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (311 aa)
LOC102745190Dystrophin-like. (642 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (252 aa)
ATP2A3Sarcoplasmic/endoplasmic reticulum calcium ATPase 3; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (604 aa)
TPM2Tropomyosin alpha-4 chain isoform X1; Belongs to the tropomyosin family. (284 aa)
TGFB1Transforming growth factor beta-1. (261 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ACTL8Actin-like protein 8; Belongs to the actin family. (366 aa)
LOC102744274Dystrophin-like. (456 aa)
TNNT3Troponin T, fast skeletal muscle. (230 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
SLC39A12Zinc transporter ZIP12. (366 aa)
TPM4Tropomyosin alpha-4 chain; Belongs to the tropomyosin family. (248 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
LMNAprelamin-A/C isoform X1; Belongs to the intermediate filament family. (666 aa)
EMDEmerin. (260 aa)
LOC102731038Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (564 aa)
LOC102730020Myosin-7-like. (703 aa)
LOC102749357Myosin-4-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (342 aa)
LOC102749446Myosin-1-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (190 aa)
LOC102726696Myosin-2-like. (199 aa)
LOC102740174Myosin-2-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (236 aa)
ACTG1LOW QUALITY PROTEIN: actin, gamma 1. (411 aa)
SLC8A1Sodium/calcium exchanger 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (970 aa)
CACNA2D1Voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1. (1091 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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