(39 nodes) Base excision repair network (Arthrobotrys flagrans)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DFL_001693	Uncharacterized protein. (515 aa)
	DFL_001984	Uncharacterized protein. (623 aa)
	DFL_002748	ENDO3c domain-containing protein. (482 aa)
	DFL_002577	Uncharacterized protein. (405 aa)
	DFL_003053	Uncharacterized protein. (530 aa)
	UNG1	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (412 aa)
	DFL_000257	ENDO3c domain-containing protein. (362 aa)
	DFL_000924	Uncharacterized protein. (209 aa)
	DFL_000950	Uncharacterized protein. (610 aa)
	DFL_000980	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (171 aa)
	DFL_002978	Vezatin domain-containing protein. (730 aa)
	DFL_008406	Uncharacterized protein. (1261 aa)
	DFL_008423	Uncharacterized protein. (475 aa)
	DFL_008804	DNA_binding_1 domain-containing protein. (131 aa)
	DFL_008769	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2219 aa)
	DFL_009477	Uncharacterized protein. (209 aa)
	NTH1	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (496 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (390 aa)
	DFL_006979	Poly [ADP-ribose] polymerase. (739 aa)
	DFL_006962	DNA_pol_E_B domain-containing protein. (812 aa)
	DFL_007048	DNA polymerase. (1097 aa)
	DFL_007275	DNA ligase. (878 aa)
	DFL_007333	LisH domain-containing protein. (382 aa)
	DFL_007841	Uncharacterized protein. (1381 aa)
	DFL_005721	Uncharacterized protein. (452 aa)
	DFL_005905	Uncharacterized protein. (461 aa)
	DFL_005678	Uncharacterized protein. (846 aa)
	DFL_006032	CBFD_NFYB_HMF domain-containing protein. (248 aa)
	DFL_006090	FPG_CAT domain-containing protein. (423 aa)
	DFL_006193	Uncharacterized protein. (245 aa)
	DFL_003301	CBFD_NFYB_HMF domain-containing protein. (193 aa)
	DFL_003561	CMP/dCMP-type deaminase domain-containing protein. (221 aa)
	DFL_003896	DNA ligase. (876 aa)
	DFL_004153	ENDO3c domain-containing protein. (397 aa)
	DFL_004162	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (347 aa)
	DFL_004314	AP_endonuc_2 domain-containing protein. (559 aa)
	DFL_004782	UDG domain-containing protein. (326 aa)
	DFL_004858	Uncharacterized protein; Belongs to the MT-A70-like family. (402 aa)
	DFL_001709	DNA_binding_1 domain-containing protein. (211 aa)

Your Current Organism:

Arthrobotrys flagrans

NCBI taxonomy Id: 97331
Other names: A. flagrans, Duddingtonia flagrans, Trichothecium flagrans

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DFL_000257	DFL_004314	A0A437ADS6	A0A437A4E8	ENDO3c domain-containing protein.	AP_endonuc_2 domain-containing protein.	0.612
DFL_000257	FEN1	A0A437ADS6	A0A436ZSK3	ENDO3c domain-containing protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.417
DFL_000257	NTH1	A0A437ADS6	A0A436ZSD6	ENDO3c domain-containing protein.	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.	0.547
DFL_000924	DFL_000980	A0A437AFN9	A0A437AFU0	Uncharacterized protein.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.841
DFL_000950	DFL_001693	A0A437AFQ8	A0A437A8H6	Uncharacterized protein.	Uncharacterized protein.	0.687
DFL_000950	DFL_002978	A0A437AFQ8	A0A437AC09	Uncharacterized protein.	Vezatin domain-containing protein.	0.866
DFL_000950	DFL_003896	A0A437AFQ8	A0A437A348	Uncharacterized protein.	DNA ligase.	0.687
DFL_000950	DFL_004162	A0A437AFQ8	A0A437A421	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.866
DFL_000950	DFL_005678	A0A437AFQ8	A0A436ZYZ2	Uncharacterized protein.	Uncharacterized protein.	0.454
DFL_000950	DFL_006032	A0A437AFQ8	A0A436ZZ22	Uncharacterized protein.	CBFD_NFYB_HMF domain-containing protein.	0.649
DFL_000950	DFL_006090	A0A437AFQ8	A0A436ZZA8	Uncharacterized protein.	FPG_CAT domain-containing protein.	0.561
DFL_000950	DFL_006962	A0A437AFQ8	A0A436ZUD9	Uncharacterized protein.	DNA_pol_E_B domain-containing protein.	0.690
DFL_000950	DFL_006979	A0A437AFQ8	A0A436ZUB7	Uncharacterized protein.	Poly [ADP-ribose] polymerase.	0.700
DFL_000950	DFL_007048	A0A437AFQ8	A0A436ZUM0	Uncharacterized protein.	DNA polymerase.	0.726
DFL_000950	DFL_007275	A0A437AFQ8	A0A436ZVW1	Uncharacterized protein.	DNA ligase.	0.687
DFL_000950	DFL_007841	A0A437AFQ8	A0A436ZXJ7	Uncharacterized protein.	Uncharacterized protein.	0.814
DFL_000950	DFL_008769	A0A437AFQ8	A0A436ZPW1	Uncharacterized protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.731
DFL_000950	FEN1	A0A437AFQ8	A0A436ZSK3	Uncharacterized protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.760
DFL_000950	NTH1	A0A437AFQ8	A0A436ZSD6	Uncharacterized protein.	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.	0.477
DFL_000980	DFL_000924	A0A437AFU0	A0A437AFN9	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	Uncharacterized protein.	0.841