STRINGSTRING
THOC1 THOC1 EZH2 EZH2 SLX4 SLX4 DHX36 DHX36 LRIF1 LRIF1 ORC4 ORC4 BLM BLM GAR1 GAR1 TP53BP1 TP53BP1 ORC1 ORC1 CHD4 CHD4 SMC6 SMC6 TEN1 TEN1 SPO11 SPO11 NSMCE2 NSMCE2 RAD51D RAD51D HMBOX1 HMBOX1 TOX4 TOX4 PPP1CC PPP1CC HDAC2 HDAC2 CDK2 CDK2 ENSTTRP00000014196 ENSTTRP00000014196 THOC3 THOC3 LRWD1 LRWD1 GATAD2B GATAD2B XRCC1 XRCC1 THOC7 THOC7 RBBP7 RBBP7 DNA2 DNA2 PPP1CA PPP1CA NBN NBN DCLRE1B DCLRE1B WRN WRN RTEL1 RTEL1 PIF1 PIF1 PML PML CHEK2 CHEK2 ORC2 ORC2 ZBTB10 ZBTB10 UPF1 UPF1 HAT1 HAT1 FEN1 FEN1 THOC6 THOC6 TFIP11 TFIP11 TERB1 TERB1 ERCC4 ERCC4 ACD ACD XRCC5 XRCC5 NSMCE1 NSMCE1 TINF2 TINF2 ERCC1 ERCC1 PPP1R10 PPP1R10 SMCHD1 SMCHD1 ENSTTRP00000007825 ENSTTRP00000007825 PPP1CB PPP1CB NABP1 NABP1 ENSTTRP00000007549 ENSTTRP00000007549 KDM1A KDM1A RPA2 RPA2 TNKS TNKS NABP2 NABP2 ZBTB48 ZBTB48 ATM ATM SUN2 SUN2 DMC1 DMC1 CCDC155 CCDC155 CBX5 CBX5 ATRX ATRX RNF8 RNF8 NSMCE4A NSMCE4A TERT TERT WRNIP1 WRNIP1 TERF1 TERF1 TERB2 TERB2 STN1 STN1 DOT1L DOT1L RAD17 RAD17 POT1 POT1 RAD50 RAD50 MTA2 MTA2 POLD1 POLD1 SIRT6 SIRT6 PINX1 PINX1 TERF2IP TERF2IP WDR82 WDR82 SMC5 SMC5 ZNF827 ZNF827 THOC5 THOC5 LOC101332449 LOC101332449 CHEK1 CHEK1 RIF1 RIF1 POLR2B POLR2B RAD51 RAD51 MRE11 MRE11 BRCA2 BRCA2 CTC1 CTC1 WRAP53 WRAP53 TERF2 TERF2 RECQL4 RECQL4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
THOC1THO complex subunit 1. (655 aa)
EZH2Histone-lysine N-methyltransferase EZH2 isoform X2. (751 aa)
SLX4Structure-specific endonuclease subunit SLX4. (1815 aa)
DHX36ATP-dependent RNA helicase DHX36 isoform X1. (1012 aa)
LRIF1Ligand-dependent nuclear receptor-interacting factor 1 isoform X1. (761 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
BLMBloom syndrome protein isoform X1. (1409 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (242 aa)
TP53BP1Tumor suppressor p53-binding protein 1 isoform X1. (1972 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (828 aa)
CHD4chromodomain-helicase-DNA-binding protein 4 isoform X1. (1904 aa)
SMC6Structural maintenance of chromosomes protein 6 isoform X1. (1097 aa)
TEN1CST complex subunit TEN1. (124 aa)
SPO11Meiotic recombination protein SPO11 isoform X1. (406 aa)
NSMCE2E3 SUMO-protein ligase NSE2 isoform X3. (246 aa)
RAD51DDNA repair protein RAD51 homolog 4. (305 aa)
HMBOX1Homeobox-containing protein 1 isoform X4. (420 aa)
TOX4TOX high mobility group box family member 4 isoform X1. (619 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (293 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (583 aa)
CDK2Cyclin dependent kinase 2. (298 aa)
ENSTTRP00000014196annotation not available (422 aa)
THOC3THO complex subunit 3. (262 aa)
LRWD1Leucine-rich repeat and WD repeat-containing protein 1. (647 aa)
GATAD2BTranscriptional repressor p66-beta isoform X4. (591 aa)
XRCC1DNA repair protein XRCC1 isoform X1. (598 aa)
THOC7THO complex subunit 7 homolog. (204 aa)
RBBP7Histone-binding protein RBBP7 isoform X1. (469 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1. (1059 aa)
PPP1CAProtein phosphatase 1 catalytic subunit alpha. (321 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (746 aa)
DCLRE1B5' exonuclease Apollo. (468 aa)
WRNWerner syndrome ATP-dependent helicase isoform X2. (1352 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1377 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (700 aa)
PMLProtein PML isoform X2. (871 aa)
CHEK2Serine/threonine-protein kinase Chk2 isoform X2. (580 aa)
ORC2Origin recognition complex subunit 2 isoform X1. (496 aa)
ZBTB10Zinc finger and BTB domain-containing protein 10. (523 aa)
UPF1Regulator of nonsense transcripts 1 isoform X2. (1112 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (419 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
THOC6THO complex 6. (342 aa)
TFIP11Tuftelin interacting protein 11. (834 aa)
TERB1Telomere repeats-binding bouquet formation protein 1. (498 aa)
ERCC4DNA repair endonuclease XPF. (914 aa)
ACDAdrenocortical dysplasia protein homolog. (533 aa)
XRCC5X-ray repair cross-complementing protein 5 isoform X1. (733 aa)
NSMCE1Non-structural maintenance of chromosomes element 1 homolog. (266 aa)
TINF2TERF1-interacting nuclear factor 2 isoform X2. (453 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (315 aa)
PPP1R10LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 1 regulatory subunit 10-like. (906 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain-containing protein 1. (1353 aa)
ENSTTRP00000007825annotation not available (269 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (367 aa)
NABP1SOSS complex subunit B2 isoform X1. (204 aa)
ENSTTRP00000007549annotation not available (156 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (869 aa)
RPA2Replication protein A 32 kDa subunit. (344 aa)
TNKSPoly [ADP-ribose] polymerase. (1312 aa)
NABP2SOSS complex subunit B1. (211 aa)
ZBTB48Zinc finger and BTB domain-containing protein 48. (684 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3043 aa)
SUN2SUN domain-containing protein 2. (699 aa)
DMC1Meiotic recombination protein DMC1/LIM15 homolog; Belongs to the RecA family. (340 aa)
CCDC155Protein KASH5. (564 aa)
CBX5Chromobox protein homolog 5. (191 aa)
ATRXTranscriptional regulator ATRX isoform X3. (2518 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (450 aa)
NSMCE4ANon-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (385 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1124 aa)
WRNIP1ATPase WRNIP1 isoform X2. (391 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (406 aa)
TERB2Telomere repeats-binding bouquet formation protein 2. (221 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specific isoform X2. (1705 aa)
RAD17Cell cycle checkpoint protein RAD17. (683 aa)
POT1Protection of telomeres protein 1 isoform X2. (634 aa)
RAD50DNA repair protein RAD50. (1267 aa)
MTA2Metastasis-associated protein MTA2 isoform X1. (661 aa)
POLD1LOW QUALITY PROTEIN: DNA polymerase delta catalytic subunit. (1125 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6 isoform X5. (245 aa)
PINX1PIN2/TERF1-interacting telomerase inhibitor 1. (312 aa)
TERF2IPTelomeric repeat-binding factor 2-interacting protein 1. (237 aa)
WDR82WD repeat-containing protein 82 isoform X1. (259 aa)
SMC5Structural maintenance of chromosomes 5. (1050 aa)
ZNF827Zinc finger protein 827. (1007 aa)
THOC5THO complex subunit 5 homolog isoform X2. (679 aa)
LOC101332449Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (318 aa)
CHEK1Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily. (475 aa)
RIF1Telomere-associated protein RIF1. (2463 aa)
POLR2BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1169 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (299 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa)
BRCA2Breast cancer type 2 susceptibility protein. (3307 aa)
CTC1CST complex subunit CTC1. (1156 aa)
WRAP53Telomerase Cajal body protein 1 isoform X1. (540 aa)
TERF2Telomeric repeat-binding factor 2 isoform X1. (500 aa)
RECQL4ATP-dependent DNA helicase Q4. (1210 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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