STRINGSTRING
SIX2 SIX2 OSR1 OSR1 GDF11 GDF11 TCF21 TCF21 BMP4 BMP4 RDH10 RDH10 LHX1 LHX1 SMO SMO DLG5 DLG5 OSR2 OSR2 IRX2 IRX2 CTNNB1 CTNNB1 GPC3 GPC3 SOX8 SOX8 SOX9 SOX9 KIF26B KIF26B APH1A APH1A BCL2 BCL2 GATA3 GATA3 GREB1L GREB1L TFAP2B TFAP2B WNT9B WNT9B GLI3 GLI3 HOXA11 HOXA11 GDNF GDNF HES1 HES1 RET RET UMOD UMOD FGF10 FGF10 FRAS1 FRAS1 AQP2 AQP2 aqp1 aqp1 GREB1 GREB1 NPHS2 NPHS2 LGR4 LGR4 SHH SHH SIX1 SIX1 SIX4 SIX4 FGF8 FGF8 PAX2 PAX2 SALL1 SALL1 SPRY1 SPRY1 PKD2 PKD2 NF1 NF1 PKD1 PKD1 ENSTTRP00000014801 ENSTTRP00000014801 BMP7 BMP7 FOXJ1 FOXJ1 ID3 ID3 CTSH CTSH LAMB2 LAMB2 PTCH1 PTCH1 FMN1 FMN1 ENSTTRP00000010363 ENSTTRP00000010363 SMAD4 SMAD4 PAX8 PAX8 NKX3-1 NKX3-1 GDF6 GDF6 PDGFRA PDGFRA EYA1 EYA1 WT1 WT1 CALB1 CALB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIX2Homeobox protein SIX2. (168 aa)
OSR1Protein odd-skipped-related 1. (267 aa)
GDF11Growth differentiation factor 11. (313 aa)
TCF21Transcription factor 21. (162 aa)
BMP4Bone morphogenetic protein 4. (407 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
LHX1LIM/homeobox protein Lhx1. (406 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
DLG5Disks large homolog 5; Belongs to the MAGUK family. (1816 aa)
OSR2Protein odd-skipped-related 2. (312 aa)
IRX2Iroquois-class homeodomain protein IRX-2. (471 aa)
CTNNB1Catenin beta-1. (781 aa)
GPC3Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (597 aa)
SOX8Transcription factor SOX-8. (445 aa)
SOX9Transcription factor SOX-9. (509 aa)
KIF26BKinesin-like protein KIF26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2101 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
GREB1LGREB1-like protein. (871 aa)
TFAP2BTranscription factor AP-2-beta isoform X4. (360 aa)
WNT9BWnt family member 9B. (330 aa)
GLI3Transcriptional activator GLI3. (1580 aa)
HOXA11Homeobox protein Hox-A11. (311 aa)
GDNFGlial cell line-derived neurotrophic factor isoform X2. (211 aa)
HES1Transcription factor HES-1. (280 aa)
RETRet proto-oncogene. (1113 aa)
UMODUromodulin. (657 aa)
FGF10Fibroblast growth factor 10. (142 aa)
FRAS1Extracellular matrix protein FRAS1. (3980 aa)
AQP2Aquaporin-2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
aqp1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (251 aa)
GREB1Growth regulating estrogen receptor binding 1. (1943 aa)
NPHS2Podocin isoform X1. (323 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1. (908 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (449 aa)
SIX1Homeobox protein SIX1. (284 aa)
SIX4Homeobox protein SIX4. (494 aa)
FGF8Fibroblast growth factor 8; Belongs to the heparin-binding growth factors family. (221 aa)
PAX2LOW QUALITY PROTEIN: paired box protein Pax-2. (419 aa)
SALL1Spalt like transcription factor 1. (1316 aa)
SPRY1Protein sprouty homolog 1. (319 aa)
PKD2Polycystin-2 isoform X2. (975 aa)
NF1Neurofibromin. (2814 aa)
PKD1Polycystin-1 isoform X3. (4289 aa)
ENSTTRP00000014801annotation not available (387 aa)
BMP7Bone morphogenetic protein 7 isoform X2. (431 aa)
FOXJ1Forkhead box protein J1. (389 aa)
ID3DNA-binding protein inhibitor ID-3. (119 aa)
CTSHCathepsin H. (335 aa)
LAMB2Laminin subunit beta-2. (1803 aa)
PTCH1Protein patched homolog 1 isoform X1. (1313 aa)
FMN1Formin-1. (648 aa)
ENSTTRP00000010363annotation not available (1047 aa)
SMAD4Mothers against decapentaplegic homolog. (407 aa)
PAX8Paired box protein Pax-8. (445 aa)
NKX3-1Homeobox protein Nkx-3.1. (138 aa)
GDF6Growth/differentiation factor 6. (458 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1040 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (589 aa)
WT1Wilms tumor protein isoform X2. (336 aa)
CALB1Calbindin. (261 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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