(48 nodes) Somitogenesis network (Tursiops truncatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	POFUT1	GDP-fucose protein O-fucosyltransferase 1 isoform X1. (390 aa)
	LEF1	Lymphoid enhancer binding factor 1. (396 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
	TCAP	Titin-cap. (167 aa)
	SEMA3C	semaphorin-3C; Belongs to the semaphorin family. (751 aa)
	LHX1	LIM/homeobox protein Lhx1. (406 aa)
	PCDH8	Protocadherin 8. (1068 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (466 aa)
	AXIN2	Axin-2-like. (839 aa)
	HES7	Hes family bHLH transcription factor 7. (226 aa)
	CRB2	Crumbs cell polarity complex component 2. (1254 aa)
	NKX3-1	Homeobox protein Nkx-3.1. (138 aa)
	SMAD4	Mothers against decapentaplegic homolog. (407 aa)
	TBXT	Brachyury protein isoform X1. (435 aa)
	MSGN1	Mesogenin-1. (188 aa)
	MESP2	Mesoderm posterior protein 2. (366 aa)
	ENSTTRP00000014726	annotation not available (263 aa)
	NLE1	Notchless protein homolog 1. (430 aa)
	MYF5	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
	POGLUT1	Protein O-glucosyltransferase 1 isoform X3. (363 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (784 aa)
	MEOX2	Homeobox protein MOX-2. (303 aa)
	COBL	Protein cordon-bleu isoform X4. (1337 aa)
	LRP6	Low-density lipoprotein receptor-related protein 6. (1611 aa)
	PLXNA2	plexin-A2. (1909 aa)
	MEOX1	Homeobox protein MOX-1 isoform X2. (251 aa)
	SFRP1	Secreted frizzled-related protein 1 isoform X2. (307 aa)
	EPB41L5	Band 4.1-like protein 5 isoform X3. (728 aa)
	ALDH1A2	Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. (518 aa)
	PAX1	Paired box protein Pax-1. (422 aa)
	MIB1	E3 ubiquitin-protein ligase MIB1. (1006 aa)
	XRCC2	DNA repair protein XRCC2 isoform X1. (267 aa)
	SMAD3	Mothers against decapentaplegic homolog 3. (291 aa)
	ABI1	Abl interactor 1 isoform X13. (492 aa)
	EP300	Histone acetyltransferase p300. (2422 aa)
	DLL3	Delta-like protein 3. (611 aa)
	SFRP2	Secreted frizzled-related protein 2. (294 aa)
	TAF10	Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (470 aa)
	MED12	Mediator of RNA polymerase II transcription subunit 12. (2173 aa)
	TBX6	T-box transcription factor 6. (435 aa)
	TBX18	T-box transcription factor TBX18. (612 aa)
	FOXF1	Forkhead box F1. (372 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3043 aa)
	KAT2A	Histone acetyltransferase KAT2A. (835 aa)
	ENSTTRP00000006381	annotation not available (382 aa)
	KDM6A	Lysine-specific demethylase 6A isoform X4. (1346 aa)
	TCF15	Transcription factor 15. (197 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH1A2	MESP2	ENSTTRP00000002211	ENSTTRP00000014727	Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family.	Mesoderm posterior protein 2.	0.493
ALDH1A2	TBX18	ENSTTRP00000002211	ENSTTRP00000005395	Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family.	T-box transcription factor TBX18.	0.499
ATM	EP300	ENSTTRP00000005735	ENSTTRP00000003136	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone acetyltransferase p300.	0.523
ATM	XRCC2	ENSTTRP00000005735	ENSTTRP00000002529	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA repair protein XRCC2 isoform X1.	0.777
AXIN2	ENSTTRP00000006381	ENSTTRP00000008850	ENSTTRP00000006381	Axin-2-like.	annotation not available	0.855
AXIN2	LEF1	ENSTTRP00000008850	ENSTTRP00000007673	Axin-2-like.	Lymphoid enhancer binding factor 1.	0.982
AXIN2	LRP6	ENSTTRP00000008850	ENSTTRP00000012124	Axin-2-like.	Low-density lipoprotein receptor-related protein 6.	0.927
AXIN2	SFRP1	ENSTTRP00000008850	ENSTTRP00000001017	Axin-2-like.	Secreted frizzled-related protein 1 isoform X2.	0.698
AXIN2	SFRP2	ENSTTRP00000008850	ENSTTRP00000004282	Axin-2-like.	Secreted frizzled-related protein 2.	0.663
AXIN2	WNT5A	ENSTTRP00000008850	ENSTTRP00000004970	Axin-2-like.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.781
BMPR1A	EP300	ENSTTRP00000007678	ENSTTRP00000003136	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Histone acetyltransferase p300.	0.445
BMPR1A	LEF1	ENSTTRP00000007678	ENSTTRP00000007673	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Lymphoid enhancer binding factor 1.	0.673
BMPR1A	SMAD3	ENSTTRP00000007678	ENSTTRP00000002846	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog 3.	0.947
BMPR1A	SMAD4	ENSTTRP00000007678	ENSTTRP00000011160	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.862
CRB2	DLL3	ENSTTRP00000010970	ENSTTRP00000003353	Crumbs cell polarity complex component 2.	Delta-like protein 3.	0.409
CRB2	EPB41L5	ENSTTRP00000010970	ENSTTRP00000001564	Crumbs cell polarity complex component 2.	Band 4.1-like protein 5 isoform X3.	0.422
CRB2	POGLUT1	ENSTTRP00000010970	ENSTTRP00000013617	Crumbs cell polarity complex component 2.	Protein O-glucosyltransferase 1 isoform X3.	0.703
CRB2	PSEN1	ENSTTRP00000010970	ENSTTRP00000008812	Crumbs cell polarity complex component 2.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.467
DLL1	DLL3	ENSTTRP00000013215	ENSTTRP00000003353	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein 3.	0.912
DLL1	ENSTTRP00000006381	ENSTTRP00000013215	ENSTTRP00000006381	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	annotation not available	0.530