(24 nodes) Endothelial cell proliferation network (Tursiops truncatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ITGB1BP1	Integrin beta-1-binding protein 1. (199 aa)
	SCARB1	Scavenger receptor class B member 1. (465 aa)
	NOX5	LOW QUALITY PROTEIN: NADPH oxidase 5. (380 aa)
	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX. (302 aa)
	BMPER	BMP-binding endothelial regulator protein. (640 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
	ENSTTRP00000004868	annotation not available (129 aa)
	TEK	Angiopoietin-1 receptor isoform X1. (1156 aa)
	VSTM4	V-set and transmembrane domain-containing protein 4. (302 aa)
	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1. (963 aa)
	ENSTTRP00000007731	annotation not available (287 aa)
	CAV2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (134 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	THAP1	THAP domain-containing protein 1 isoform X2. (213 aa)
	BMP4	Bone morphogenetic protein 4. (407 aa)
	FGF10	Fibroblast growth factor 10. (142 aa)
	LOXL2	Lysyl oxidase homolog 2. (771 aa)
	DLG1	Disks large homolog 1 isoform X3; Belongs to the MAGUK family. (920 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (458 aa)
	DLG2	Disks large homolog 2 isoform X2. (966 aa)
	NF1	Neurofibromin. (2814 aa)
	PROK1	Prokineticin-1. (105 aa)
	EPHA2	Ephrin type-A receptor 2-like. (974 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	BMPER	ENSTTRP00000008787	ENSTTRP00000003360	Bone morphogenetic protein 4.	BMP-binding endothelial regulator protein.	0.722
BMP4	BMPR2	ENSTTRP00000008787	ENSTTRP00000004697	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.986
BMP4	ENSTTRP00000007731	ENSTTRP00000008787	ENSTTRP00000007731	Bone morphogenetic protein 4.	annotation not available	0.763
BMP4	FGF10	ENSTTRP00000008787	ENSTTRP00000009805	Bone morphogenetic protein 4.	Fibroblast growth factor 10.	0.819
BMP4	FGF7	ENSTTRP00000008787	ENSTTRP00000008275	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.658
BMP4	TGFBR1	ENSTTRP00000008787	ENSTTRP00000012962	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.835
BMPER	BMP4	ENSTTRP00000003360	ENSTTRP00000008787	BMP-binding endothelial regulator protein.	Bone morphogenetic protein 4.	0.722
BMPR2	BMP4	ENSTTRP00000004697	ENSTTRP00000008787	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.986
BMPR2	TGFBR1	ENSTTRP00000004697	ENSTTRP00000012962	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.744
CAV1	CAV2	ENSTTRP00000008073	ENSTTRP00000008061	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.999
CAV1	EPHA2	ENSTTRP00000008073	ENSTTRP00000016478	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Ephrin type-A receptor 2-like.	0.532
CAV1	TGFBR1	ENSTTRP00000008073	ENSTTRP00000012962	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.555
CAV2	CAV1	ENSTTRP00000008061	ENSTTRP00000008073	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.999
DLG1	DLG2	ENSTTRP00000011781	ENSTTRP00000013949	Disks large homolog 1 isoform X3; Belongs to the MAGUK family.	Disks large homolog 2 isoform X2.	0.898
DLG2	DLG1	ENSTTRP00000013949	ENSTTRP00000011781	Disks large homolog 2 isoform X2.	Disks large homolog 1 isoform X3; Belongs to the MAGUK family.	0.898
ENSTTRP00000007731	BMP4	ENSTTRP00000007731	ENSTTRP00000008787	annotation not available	Bone morphogenetic protein 4.	0.763
ENSTTRP00000007731	EPHA2	ENSTTRP00000007731	ENSTTRP00000016478	annotation not available	Ephrin type-A receptor 2-like.	0.862
ENSTTRP00000007731	FGF10	ENSTTRP00000007731	ENSTTRP00000009805	annotation not available	Fibroblast growth factor 10.	0.544
ENSTTRP00000007731	FGF7	ENSTTRP00000007731	ENSTTRP00000008275	annotation not available	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.474
ENSTTRP00000007731	TEK	ENSTTRP00000007731	ENSTTRP00000005143	annotation not available	Angiopoietin-1 receptor isoform X1.	0.942