(45 nodes) Sprouting angiogenesis network (Tursiops truncatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NRP1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	VEGFB	Vascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family. (172 aa)
	EPHB4	Ephrin type-B receptor 4. (980 aa)
	RAMP2	Receptor activity modifying protein 2. (176 aa)
	LOXL2	Lysyl oxidase homolog 2. (771 aa)
	EGR3	Early growth response 3. (387 aa)
	PIK3R3	Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (784 aa)
	RECK	Reversion-inducing cysteine-rich protein with Kazal motifs. (971 aa)
	THBS1	Thrombospondin-1. (1144 aa)
	E2F7	Transcription factor E2F7. (904 aa)
	GPLD1	Phosphatidylinositol-glycan-specific phospholipase D isoform X2. (811 aa)
	PARVA	Alpha-parvin isoform X1. (371 aa)
	ENSTTRP00000000494	annotation not available (1039 aa)
	RNF213	E3 ubiquitin-protein ligase RNF213. (3260 aa)
	ITGB1BP1	Integrin beta-1-binding protein 1. (199 aa)
	JMJD6	Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform X1. (402 aa)
	PGF	Placenta growth factor; Belongs to the PDGF/VEGF growth factor family. (215 aa)
	OTULIN	Ubiquitin thioesterase otulin isoform X1. (352 aa)
	PTK2B	Protein-tyrosine kinase 2-beta isoform X2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (941 aa)
	KDR	Vascular endothelial growth factor receptor 2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1307 aa)
	NR4A1	Nuclear receptor subfamily 4 group A member 1. (632 aa)
	BMPER	BMP-binding endothelial regulator protein. (640 aa)
	RSPO3	R-spondin-3. (293 aa)
	VEGFC	Vascular endothelial growth factor C isoform X1; Belongs to the PDGF/VEGF growth factor family. (420 aa)
	SEMA3E	semaphorin-3E; Belongs to the semaphorin family. (775 aa)
	TEK	Angiopoietin-1 receptor isoform X1. (1156 aa)
	E2F8	Transcription factor E2F8 isoform X1. (866 aa)
	SLIT2	Slit homolog 2 protein isoform X2. (1470 aa)
	VSTM4	V-set and transmembrane domain-containing protein 4. (302 aa)
	EFNB2	ephrin-B2; Belongs to the ephrin family. (333 aa)
	SRF	Serum response factor isoform X2. (509 aa)
	NOTCH1	Neurogenic locus notch homolog protein 1. (2527 aa)
	LEF1	Lymphoid enhancer binding factor 1. (396 aa)
	MMRN2	Multimerin-2. (935 aa)
	ENSTTRP00000007731	annotation not available (287 aa)
	ESM1	Endothelial cell-specific molecule 1 isoform X1. (184 aa)
	CDH13	Cadherin-13 isoform X2. (608 aa)
	BMP4	Bone morphogenetic protein 4. (407 aa)
	ROBO1	Roundabout homolog 1 isoform X4. (1622 aa)
	ADTRP	Androgen-dependent TFPI-regulating protein isoform X1. (224 aa)
	ENSTTRP00000009296	annotation not available (181 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (786 aa)
	ADGRA2	Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1246 aa)
	EPHA2	Ephrin type-A receptor 2-like. (974 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADGRA2	RECK	ENSTTRP00000016062	ENSTTRP00000015430	Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family.	Reversion-inducing cysteine-rich protein with Kazal motifs.	0.533
BMP4	BMPER	ENSTTRP00000008787	ENSTTRP00000003360	Bone morphogenetic protein 4.	BMP-binding endothelial regulator protein.	0.722
BMP4	ENSTTRP00000007731	ENSTTRP00000008787	ENSTTRP00000007731	Bone morphogenetic protein 4.	annotation not available	0.763
BMP4	ITGB1	ENSTTRP00000008787	ENSTTRP00000009434	Bone morphogenetic protein 4.	Integrin beta; Belongs to the integrin beta chain family.	0.426
BMP4	KDR	ENSTTRP00000008787	ENSTTRP00000002294	Bone morphogenetic protein 4.	Vascular endothelial growth factor receptor 2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.543
BMP4	LEF1	ENSTTRP00000008787	ENSTTRP00000007673	Bone morphogenetic protein 4.	Lymphoid enhancer binding factor 1.	0.666
BMP4	NOTCH1	ENSTTRP00000008787	ENSTTRP00000007173	Bone morphogenetic protein 4.	Neurogenic locus notch homolog protein 1.	0.417
BMPER	BMP4	ENSTTRP00000003360	ENSTTRP00000008787	BMP-binding endothelial regulator protein.	Bone morphogenetic protein 4.	0.722
DLL1	ENSTTRP00000009296	ENSTTRP00000013215	ENSTTRP00000009296	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	annotation not available	0.846
DLL1	NOTCH1	ENSTTRP00000013215	ENSTTRP00000007173	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch homolog protein 1.	0.996
E2F7	E2F8	ENSTTRP00000000102	ENSTTRP00000005390	Transcription factor E2F7.	Transcription factor E2F8 isoform X1.	0.980
E2F8	E2F7	ENSTTRP00000005390	ENSTTRP00000000102	Transcription factor E2F8 isoform X1.	Transcription factor E2F7.	0.980
EFNB2	EPHA2	ENSTTRP00000006445	ENSTTRP00000016478	ephrin-B2; Belongs to the ephrin family.	Ephrin type-A receptor 2-like.	0.909
EFNB2	EPHB4	ENSTTRP00000006445	ENSTTRP00000010523	ephrin-B2; Belongs to the ephrin family.	Ephrin type-B receptor 4.	0.999
EFNB2	ESM1	ENSTTRP00000006445	ENSTTRP00000008195	ephrin-B2; Belongs to the ephrin family.	Endothelial cell-specific molecule 1 isoform X1.	0.562
EFNB2	NOTCH1	ENSTTRP00000006445	ENSTTRP00000007173	ephrin-B2; Belongs to the ephrin family.	Neurogenic locus notch homolog protein 1.	0.420
EFNB2	NRP1	ENSTTRP00000006445	ENSTTRP00000009446	ephrin-B2; Belongs to the ephrin family.	Neuropilin; Belongs to the neuropilin family.	0.673
EFNB2	TEK	ENSTTRP00000006445	ENSTTRP00000005143	ephrin-B2; Belongs to the ephrin family.	Angiopoietin-1 receptor isoform X1.	0.491
EFNB2	THBS1	ENSTTRP00000006445	ENSTTRP00000000028	ephrin-B2; Belongs to the ephrin family.	Thrombospondin-1.	0.414
EFNB2	VEGFC	ENSTTRP00000006445	ENSTTRP00000004737	ephrin-B2; Belongs to the ephrin family.	Vascular endothelial growth factor C isoform X1; Belongs to the PDGF/VEGF growth factor family.	0.540