STRINGSTRING
CLUAP1 CLUAP1 TBX20 TBX20 DSP DSP TBXT TBXT EGLN1 EGLN1 IFT57 IFT57 ENG ENG HEY2 HEY2 SEC24B SEC24B WNT16 WNT16 ADAM15 ADAM15 EFNA1 EFNA1 HTR2B HTR2B NIPBL NIPBL MYL3 MYL3 BMP7 BMP7 MESP2 MESP2 ENSTTRP00000014726 ENSTTRP00000014726 NPHP3 NPHP3 APLNR APLNR PKD2 PKD2 MICAL2 MICAL2 ADGRG6 ADGRG6 FGF8 FGF8 MYL2 MYL2 LBX1 LBX1 NRP2 NRP2 ANKRD1 ANKRD1 CCDC39 CCDC39 TAB1 TAB1 EXT1 EXT1 ZFPM1 ZFPM1 ADPRH ADPRH SOS1 SOS1 HEYL HEYL MYBPC3 MYBPC3 TGFBR3 TGFBR3 DLL1 DLL1 GJA5 GJA5 FLNA FLNA MEGF8 MEGF8 SIX1 SIX1 SHH SHH NSD2 NSD2 TGFBR1 TGFBR1 CITED2 CITED2 TGFB2 TGFB2 BMP10 BMP10 TBX19 TBX19 GATA6 GATA6 WNT11 WNT11 CPE CPE TGFB1 TGFB1 HIF1A HIF1A EYA1 EYA1 MSX1 MSX1 SYNPO2L SYNPO2L GATA4 GATA4 PTCD2 PTCD2 SMAD4 SMAD4 TMEM100 TMEM100 YAP1 YAP1 JUN JUN DLL4 DLL4 PLXND1 PLXND1 GATA5 GATA5 PTCH1 PTCH1 ISL1 ISL1 FOLR1 FOLR1 WNT2 WNT2 SMAD6 SMAD6 IHH IHH ENSTTRP00000009296 ENSTTRP00000009296 DVL2 DVL2 CERT1 CERT1 SAV1 SAV1 AXIN2 AXIN2 PSEN1 PSEN1 BMP4 BMP4 CRKL CRKL COL5A1 COL5A1 INSR INSR ASB2 ASB2 SEMA3C SEMA3C ELN ELN RYR2 RYR2 TNNC1 TNNC1 MED1 MED1 SMO SMO SUFU SUFU GSK3A GSK3A PPP1R13L PPP1R13L TCAP TCAP BMPR1A BMPR1A ADAMTS1 ADAMTS1 ASXL1 ASXL1 ENSTTRP00000007523 ENSTTRP00000007523 MYLK2 MYLK2 ALPK2 ALPK2 NOTCH1 NOTCH1 FHL2 FHL2 ARL13B ARL13B SRF SRF LEMD2 LEMD2 MKS1 MKS1 MICAL2-2 MICAL2-2 KDM6A KDM6A ENSTTRP00000006381 ENSTTRP00000006381 LRP2 LRP2 CCDC103 CCDC103 JAG1 JAG1 NPY2R NPY2R EDN1 EDN1 CAV3 CAV3 ZMPSTE24 ZMPSTE24 MYL10 MYL10 FOXF1 FOXF1 GRHL2 GRHL2 SOX9 SOX9 TBX6 TBX6 TEK TEK TEAD2 TEAD2 WNT5A WNT5A AHI1 AHI1 GATA3 GATA3 BMPR2 BMPR2 ACVRL1 ACVRL1 S1PR1 S1PR1 DCHS1 DCHS1 ILK ILK POU4F1 POU4F1 DHRS3 DHRS3 ARID2 ARID2 ADPRHL1 ADPRHL1 RTN4 RTN4 SFRP2 SFRP2 TBX2 TBX2 IFT52 IFT52 NKX2-5 NKX2-5 SMAD7 SMAD7 CHD7 CHD7 HEG1 HEG1 ZFPM2 ZFPM2 SLIT3 SLIT3 PKP2 PKP2 MEF2C MEF2C XIRP2 XIRP2 ZIC3 ZIC3 PROX1 PROX1 HAS2 HAS2 TBX3 TBX3 NODAL NODAL SMAD3 SMAD3 HAND1 HAND1 NPY1R NPY1R MIB1 MIB1 BMP2 BMP2 EDNRA EDNRA ALDH1A2 ALDH1A2 DNAAF1 DNAAF1 SNAI1 SNAI1 FOXH1 FOXH1 DNAH11 DNAH11 SHOX2 SHOX2 HES1 HES1 TNNT2 TNNT2 HAND2 HAND2 CYR61 CYR61 MTOR MTOR RBM15 RBM15 TBX5 TBX5 SMARCD3 SMARCD3 COL2A1 COL2A1 GAA GAA CCDC40 CCDC40 PARVA PARVA ATF2 ATF2 NOTCH2 NOTCH2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CLUAP1Clusterin-associated protein 1 isoform X4. (412 aa)
TBX20T-box transcription factor TBX20. (449 aa)
DSPDesmoplakin isoform X1. (2806 aa)
TBXTBrachyury protein isoform X1. (435 aa)
EGLN1Egl nine homolog 1 isoform X1. (378 aa)
IFT57Intraflagellar transport protein 57 homolog. (427 aa)
ENGEndoglin. (655 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2. (336 aa)
SEC24BProtein transport protein Sec24B. (1253 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
ADAM15ADAM metallopeptidase domain 15. (862 aa)
EFNA1ephrin-A1 isoform X2; Belongs to the ephrin family. (205 aa)
HTR2BLOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 2B. (479 aa)
NIPBLNipped-B protein. (2801 aa)
MYL3Myosin light chain 3. (197 aa)
BMP7Bone morphogenetic protein 7 isoform X2. (431 aa)
MESP2Mesoderm posterior protein 2. (366 aa)
ENSTTRP00000014726annotation not available (263 aa)
NPHP3Nephrocystin-3 isoform X1. (1356 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (383 aa)
PKD2Polycystin-2 isoform X2. (975 aa)
MICAL2Protein-methionine sulfoxide oxidase MICAL2 isoform X5. (1119 aa)
ADGRG6Adhesion G-protein coupled receptor G6 isoform X1; Belongs to the G-protein coupled receptor 2 family. (1248 aa)
FGF8Fibroblast growth factor 8; Belongs to the heparin-binding growth factors family. (221 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (166 aa)
LBX1Transcription factor LBX1. (281 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
ANKRD1Ankyrin repeat domain-containing protein 1. (318 aa)
CCDC39Coiled-coil domain-containing protein 39. (732 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (502 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (746 aa)
ZFPM1Zinc finger protein ZFPM1. (984 aa)
ADPRHADP-ribosylarginine hydrolase isoform X2. (339 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1304 aa)
HEYLHairy/enhancer-of-split related with YRPW motif-like protein. (323 aa)
MYBPC3Myosin binding protein C, cardiac. (1266 aa)
TGFBR3Transforming growth factor beta receptor type 3 isoform X4. (848 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (784 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
FLNAfilamin-A-like. (2634 aa)
MEGF8Multiple epidermal growth factor-like domains protein 8. (2767 aa)
SIX1Homeobox protein SIX1. (284 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (449 aa)
NSD2Histone-lysine N-methyltransferase NSD2. (1357 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (458 aa)
CITED2Cbp/p300-interacting transactivator 2. (272 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (416 aa)
BMP10Bone morphogenetic protein 10. (423 aa)
TBX19T-box transcription factor TBX19. (446 aa)
GATA6Transcription factor GATA-6. (592 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (296 aa)
CPECarboxypeptidase E. (473 aa)
TGFB1Transforming growth factor beta 1. (338 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (824 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (589 aa)
MSX1Homeobox protein MSX-1. (303 aa)
SYNPO2LSynaptopodin 2 like. (974 aa)
GATA4Transcription factor GATA-4 isoform X2. (442 aa)
PTCD2Pentatricopeptide repeat-containing protein 2, mitochondrial. (388 aa)
SMAD4Mothers against decapentaplegic homolog. (407 aa)
TMEM100Transmembrane protein 100. (134 aa)
YAP1Transcriptional coactivator YAP1 isoform X4. (488 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (321 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (750 aa)
PLXND1plexin-D1. (1687 aa)
GATA5GATA binding protein 5. (398 aa)
PTCH1Protein patched homolog 1 isoform X1. (1313 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
FOLR1Folate receptor gamma. (251 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
SMAD6SMAD family member 6. (492 aa)
IHHIndian hedgehog protein. (409 aa)
ENSTTRP00000009296annotation not available (181 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2 isoform X9. (736 aa)
CERT1Collagen type IV alpha-3-binding protein isoform X2. (755 aa)
SAV1Protein salvador homolog 1. (385 aa)
AXIN2Axin-2-like. (839 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (466 aa)
BMP4Bone morphogenetic protein 4. (407 aa)
CRKLCrk-like protein. (303 aa)
COL5A1Collagen alpha-1(V) chain-like. (1839 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
ASB2Ankyrin repeat and SOCS box protein 2 isoform X1. (585 aa)
SEMA3Csemaphorin-3C; Belongs to the semaphorin family. (751 aa)
ELNElastin. (728 aa)
RYR2Ryanodine receptor 2. (4945 aa)
TNNC1Troponin C, slow skeletal and cardiac muscles. (161 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1512 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (423 aa)
GSK3AGlycogen synthase kinase-3 alpha. (483 aa)
PPP1R13LLOW QUALITY PROTEIN: relA-associated inhibitor. (814 aa)
TCAPTitin-cap. (167 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
ADAMTS1A disintegrin and metalloproteinase with thrombospondin motifs 1. (956 aa)
ASXL1Putative Polycomb group protein ASXL1 isoform X1. (1526 aa)
ENSTTRP00000007523annotation not available (571 aa)
MYLK2Myosin light chain kinase 2. (597 aa)
ALPK2Alpha-protein kinase 2. (2163 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2527 aa)
FHL2Four and a half LIM domains protein 2 isoform X1. (362 aa)
ARL13BADP-ribosylation factor-like protein 13B. (410 aa)
SRFSerum response factor isoform X2. (509 aa)
LEMD2LEM domain-containing protein 2 isoform X1. (503 aa)
MKS1Meckel syndrome type 1 protein. (559 aa)
MICAL2-2Protein-methionine sulfoxide oxidase MICAL2 isoform X1. (684 aa)
KDM6ALysine-specific demethylase 6A isoform X4. (1346 aa)
ENSTTRP00000006381annotation not available (382 aa)
LRP2Low-density lipoprotein receptor-related protein 2. (4599 aa)
CCDC103Coiled-coil domain-containing protein 103. (235 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
NPY2RNeuropeptide Y receptor type 2; Belongs to the G-protein coupled receptor 1 family. (382 aa)
EDN1Endothelin-1. (202 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (192 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
MYL10Myosin light chain 10. (117 aa)
FOXF1Forkhead box F1. (372 aa)
GRHL2Grainyhead-like protein 2 homolog isoform X4. (619 aa)
SOX9Transcription factor SOX-9. (509 aa)
TBX6T-box transcription factor 6. (435 aa)
TEKAngiopoietin-1 receptor isoform X1. (1156 aa)
TEAD2Transcriptional enhancer factor TEF-4 isoform X2. (447 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (470 aa)
AHI1Jouberin isoform X1. (1168 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
ACVRL1Activin A receptor like type 1. (497 aa)
S1PR1Sphingosine 1-phosphate receptor 1 isoform X2; Belongs to the G-protein coupled receptor 1 family. (382 aa)
DCHS1Protocadherin-16. (3134 aa)
ILKIntegrin-linked protein kinase. (450 aa)
POU4F1POU domain protein. (419 aa)
DHRS3Short-chain dehydrogenase/reductase 3 isoform X2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (301 aa)
ARID2AT-rich interactive domain-containing protein 2 isoform X2. (1772 aa)
ADPRHL1Protein ADP-ribosylarginine hydrolase-like protein 1. (353 aa)
RTN4Reticulon. (1189 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
TBX2T-box transcription factor TBX2. (703 aa)
IFT52Intraflagellar transport protein 52 homolog isoform X1. (437 aa)
NKX2-5Homeobox protein Nkx-2.5. (323 aa)
SMAD7Mothers against decapentaplegic homolog 7 isoform X1. (426 aa)
CHD7chromodomain-helicase-DNA-binding protein 7 isoform X3. (2970 aa)
HEG1Protein HEG homolog 1 isoform X1. (1370 aa)
ZFPM2Zinc finger protein ZFPM2. (1148 aa)
SLIT3Slit homolog 3 protein. (1521 aa)
PKP2Plakophilin-2. (839 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X1. (472 aa)
XIRP2Xin actin-binding repeat-containing protein 2 isoform X1. (3547 aa)
ZIC3Zinc finger protein ZIC 3 isoform X1. (462 aa)
PROX1Prospero homeobox protein 1. (744 aa)
HAS2Hyaluronan synthase 2. (552 aa)
TBX3T-box transcription factor TBX3. (742 aa)
NODALNodal homolog. (348 aa)
SMAD3Mothers against decapentaplegic homolog 3. (291 aa)
HAND1Heart- and neural crest derivatives-expressed protein 1. (218 aa)
NPY1RNeuropeptide Y receptor type 1; Belongs to the G-protein coupled receptor 1 family. (383 aa)
MIB1E3 ubiquitin-protein ligase MIB1. (1006 aa)
BMP2Bone morphogenetic protein 2. (388 aa)
EDNRAEndothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
ALDH1A2Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. (518 aa)
DNAAF1Dynein assembly factor 1, axonemal. (647 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
FOXH1Forkhead box H1. (360 aa)
DNAH11LOW QUALITY PROTEIN: dynein heavy chain 11, axonemal. (4523 aa)
SHOX2LOW QUALITY PROTEIN: short stature homeobox protein 2. (282 aa)
HES1Transcription factor HES-1. (280 aa)
TNNT2Troponin T, cardiac muscle. (283 aa)
HAND2Heart- and neural crest derivatives-expressed protein 2. (208 aa)
CYR61Protein CYR61. (382 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2442 aa)
RBM15Putative RNA-binding protein 15. (975 aa)
TBX5T-box transcription factor TBX5. (519 aa)
SMARCD3SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3. (369 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
GAALysosomal alpha-glucosidase-like; Belongs to the glycosyl hydrolase 31 family. (943 aa)
CCDC40Coiled-coil domain-containing protein 40. (1124 aa)
PARVAAlpha-parvin isoform X1. (371 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform X1. (2471 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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