STRINGSTRING
SMAD7 SMAD7 CHD7 CHD7 HEG1 HEG1 ZFPM2 ZFPM2 SLIT3 SLIT3 PKP2 PKP2 MEF2C MEF2C PROX1 PROX1 TBX3 TBX3 HAND1 HAND1 BMP2 BMP2 EDNRA EDNRA FOXH1 FOXH1 DNAH11 DNAH11 SHOX2 SHOX2 HES1 HES1 TNNT2 TNNT2 FGF8 FGF8 CYR61 CYR61 RBM15 RBM15 TBX5 TBX5 SMARCD3 SMARCD3 PARVA PARVA NOTCH2 NOTCH2 ADGRG6 ADGRG6 APLNR APLNR ENSTTRP00000014726 ENSTTRP00000014726 BMP7 BMP7 MYL3 MYL3 HEY2 HEY2 ENG ENG EGLN1 EGLN1 DSP DSP TBX20 TBX20 HAND2 HAND2 MYL2 MYL2 NRP2 NRP2 ZFPM1 ZFPM1 ADPRH ADPRH SOS1 SOS1 HEYL HEYL MYBPC3 MYBPC3 NSD2 NSD2 TGFBR1 TGFBR1 CITED2 CITED2 BMP10 BMP10 GATA6 GATA6 WNT11 WNT11 CPE CPE TGFB1 TGFB1 HIF1A HIF1A GATA4 GATA4 PTCD2 PTCD2 SMAD4 SMAD4 DLL4 DLL4 ISL1 ISL1 WNT2 WNT2 SMAD6 SMAD6 ENSTTRP00000009296 ENSTTRP00000009296 SAV1 SAV1 BMP4 BMP4 SEMA3C SEMA3C RYR2 RYR2 TNNC1 TNNC1 MED1 MED1 SMO SMO GSK3A GSK3A PPP1R13L PPP1R13L BMPR1A BMPR1A ADAMTS1 ADAMTS1 NOTCH1 NOTCH1 FHL2 FHL2 SRF SRF MKS1 MKS1 LRP2 LRP2 JAG1 JAG1 NPY2R NPY2R CAV3 CAV3 MYL10 MYL10 FOXF1 FOXF1 GRHL2 GRHL2 TEK TEK WNT5A WNT5A GATA3 GATA3 BMPR2 BMPR2 POU4F1 POU4F1 DHRS3 DHRS3 ADPRHL1 ADPRHL1 SFRP2 SFRP2 TBX2 TBX2 NKX2-5 NKX2-5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD7Mothers against decapentaplegic homolog 7 isoform X1. (426 aa)
CHD7chromodomain-helicase-DNA-binding protein 7 isoform X3. (2970 aa)
HEG1Protein HEG homolog 1 isoform X1. (1370 aa)
ZFPM2Zinc finger protein ZFPM2. (1148 aa)
SLIT3Slit homolog 3 protein. (1521 aa)
PKP2Plakophilin-2. (839 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X1. (472 aa)
PROX1Prospero homeobox protein 1. (744 aa)
TBX3T-box transcription factor TBX3. (742 aa)
HAND1Heart- and neural crest derivatives-expressed protein 1. (218 aa)
BMP2Bone morphogenetic protein 2. (388 aa)
EDNRAEndothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
FOXH1Forkhead box H1. (360 aa)
DNAH11LOW QUALITY PROTEIN: dynein heavy chain 11, axonemal. (4523 aa)
SHOX2LOW QUALITY PROTEIN: short stature homeobox protein 2. (282 aa)
HES1Transcription factor HES-1. (280 aa)
TNNT2Troponin T, cardiac muscle. (283 aa)
FGF8Fibroblast growth factor 8; Belongs to the heparin-binding growth factors family. (221 aa)
CYR61Protein CYR61. (382 aa)
RBM15Putative RNA-binding protein 15. (975 aa)
TBX5T-box transcription factor TBX5. (519 aa)
SMARCD3SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3. (369 aa)
PARVAAlpha-parvin isoform X1. (371 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform X1. (2471 aa)
ADGRG6Adhesion G-protein coupled receptor G6 isoform X1; Belongs to the G-protein coupled receptor 2 family. (1248 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (383 aa)
ENSTTRP00000014726annotation not available (263 aa)
BMP7Bone morphogenetic protein 7 isoform X2. (431 aa)
MYL3Myosin light chain 3. (197 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2. (336 aa)
ENGEndoglin. (655 aa)
EGLN1Egl nine homolog 1 isoform X1. (378 aa)
DSPDesmoplakin isoform X1. (2806 aa)
TBX20T-box transcription factor TBX20. (449 aa)
HAND2Heart- and neural crest derivatives-expressed protein 2. (208 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (166 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
ZFPM1Zinc finger protein ZFPM1. (984 aa)
ADPRHADP-ribosylarginine hydrolase isoform X2. (339 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1304 aa)
HEYLHairy/enhancer-of-split related with YRPW motif-like protein. (323 aa)
MYBPC3Myosin binding protein C, cardiac. (1266 aa)
NSD2Histone-lysine N-methyltransferase NSD2. (1357 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (458 aa)
CITED2Cbp/p300-interacting transactivator 2. (272 aa)
BMP10Bone morphogenetic protein 10. (423 aa)
GATA6Transcription factor GATA-6. (592 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (296 aa)
CPECarboxypeptidase E. (473 aa)
TGFB1Transforming growth factor beta 1. (338 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (824 aa)
GATA4Transcription factor GATA-4 isoform X2. (442 aa)
PTCD2Pentatricopeptide repeat-containing protein 2, mitochondrial. (388 aa)
SMAD4Mothers against decapentaplegic homolog. (407 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (750 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
SMAD6SMAD family member 6. (492 aa)
ENSTTRP00000009296annotation not available (181 aa)
SAV1Protein salvador homolog 1. (385 aa)
BMP4Bone morphogenetic protein 4. (407 aa)
SEMA3Csemaphorin-3C; Belongs to the semaphorin family. (751 aa)
RYR2Ryanodine receptor 2. (4945 aa)
TNNC1Troponin C, slow skeletal and cardiac muscles. (161 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1512 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
GSK3AGlycogen synthase kinase-3 alpha. (483 aa)
PPP1R13LLOW QUALITY PROTEIN: relA-associated inhibitor. (814 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
ADAMTS1A disintegrin and metalloproteinase with thrombospondin motifs 1. (956 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2527 aa)
FHL2Four and a half LIM domains protein 2 isoform X1. (362 aa)
SRFSerum response factor isoform X2. (509 aa)
MKS1Meckel syndrome type 1 protein. (559 aa)
LRP2Low-density lipoprotein receptor-related protein 2. (4599 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
NPY2RNeuropeptide Y receptor type 2; Belongs to the G-protein coupled receptor 1 family. (382 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (192 aa)
MYL10Myosin light chain 10. (117 aa)
FOXF1Forkhead box F1. (372 aa)
GRHL2Grainyhead-like protein 2 homolog isoform X4. (619 aa)
TEKAngiopoietin-1 receptor isoform X1. (1156 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (470 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
POU4F1POU domain protein. (419 aa)
DHRS3Short-chain dehydrogenase/reductase 3 isoform X2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (301 aa)
ADPRHL1Protein ADP-ribosylarginine hydrolase-like protein 1. (353 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
TBX2T-box transcription factor TBX2. (703 aa)
NKX2-5Homeobox protein Nkx-2.5. (323 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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