STRINGSTRING
CHD5 CHD5 MRE11 MRE11 RAD51 RAD51 ERCC6L ERCC6L RFC3 RFC3 UPF1 UPF1 CHD1L CHD1L SUB1 SUB1 MCM2 MCM2 ERCC3 ERCC3 DHX36 DHX36 RFC4 RFC4 BLM BLM PIF1 PIF1 CHD9 CHD9 MCM7 MCM7 WRN WRN SMARCAD1 SMARCAD1 NAV2 NAV2 DSCC1 DSCC1 CHD2 CHD2 RUVBL1 RUVBL1 RUVBL2 RUVBL2 FBH1 FBH1 CHD4 CHD4 CHD8 CHD8 RECQL5 RECQL5 RTEL1 RTEL1 TWNK TWNK MCM9 MCM9 HFM1 HFM1 CHD1 CHD1 IGHMBP2 IGHMBP2 CHD6 CHD6 DNA2 DNA2 MCM8 MCM8 POLQ POLQ DDX3X DDX3X RAD50 RAD50 GTF2F2 GTF2F2 RECQL RECQL MCM6 MCM6 MCM3 MCM3 WRNIP1 WRNIP1 CHD7 CHD7 ATRX ATRX BRIP1 BRIP1 HELQ HELQ FANCM FANCM XRCC6 XRCC6 MCM5 MCM5 DHX9 DHX9 SUPV3L1 SUPV3L1 ASCC3 ASCC3 ERCC2 ERCC2 MCM4 MCM4 RFC2 RFC2 C17orf64 C17orf64 DQX1 DQX1 XRCC5 XRCC5 HELB HELB G3BP1 G3BP1 RECQL4 RECQL4 CHTF18 CHTF18 TM4SF19 TM4SF19 CHD3 CHD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHD5Chromodomain helicase DNA binding protein 5. (1917 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (299 aa)
ERCC6LDNA excision repair protein ERCC-6-like. (1248 aa)
RFC3Replication factor C subunit 3 isoform X2. (355 aa)
UPF1Regulator of nonsense transcripts 1 isoform X2. (1112 aa)
CHD1Lchromodomain-helicase-DNA-binding protein 1-like isoform X2. (855 aa)
SUB1Activated RNA polymerase II transcriptional coactivator p15. (103 aa)
MCM2Minichromosome maintenance complex component 2. (905 aa)
ERCC3TFIIH basal transcription factor complex helicase XPB subunit isoform X1. (780 aa)
DHX36ATP-dependent RNA helicase DHX36 isoform X1. (1012 aa)
RFC4Replication factor C subunit 4. (364 aa)
BLMBloom syndrome protein isoform X1. (1409 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (700 aa)
CHD9chromodomain-helicase-DNA-binding protein 9 isoform X2. (2896 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (718 aa)
WRNWerner syndrome ATP-dependent helicase isoform X2. (1352 aa)
SMARCAD1annotation not available (1002 aa)
NAV2Neuron navigator 2 isoform X1. (2479 aa)
DSCC1Sister chromatid cohesion protein DCC1 isoform X1. (392 aa)
CHD2chromodomain-helicase-DNA-binding protein 2 isoform X2. (1828 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (454 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (443 aa)
FBH1F-box DNA helicase 1 isoform X2. (1074 aa)
CHD4chromodomain-helicase-DNA-binding protein 4 isoform X1. (1904 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2299 aa)
RECQL5ATP-dependent DNA helicase Q5 isoform X2. (946 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1377 aa)
TWNKTwinkle protein, mitochondrial. (683 aa)
MCM9DNA helicase MCM9 isoform X4; Belongs to the MCM family. (696 aa)
HFM1Probable ATP-dependent DNA helicase HFM1. (1411 aa)
CHD1chromodomain-helicase-DNA-binding protein 1 isoform X4. (1708 aa)
IGHMBP2DNA-binding protein SMUBP-2. (980 aa)
CHD6chromodomain-helicase-DNA-binding protein 6. (2717 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1. (1059 aa)
MCM8DNA helicase MCM8 isoform X1; Belongs to the MCM family. (821 aa)
POLQDNA polymerase theta. (2722 aa)
DDX3XATP-dependent RNA helicase DDX3X; Belongs to the DEAD box helicase family. (645 aa)
RAD50DNA repair protein RAD50. (1267 aa)
GTF2F2LOW QUALITY PROTEIN: general transcription factor IIF subunit 2-like. (242 aa)
RECQLATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (649 aa)
MCM6DNA helicase; Belongs to the MCM family. (820 aa)
MCM3DNA helicase; Belongs to the MCM family. (801 aa)
WRNIP1ATPase WRNIP1 isoform X2. (391 aa)
CHD7chromodomain-helicase-DNA-binding protein 7 isoform X3. (2970 aa)
ATRXTranscriptional regulator ATRX isoform X3. (2518 aa)
BRIP1Fanconi anemia group J protein isoform X1. (1232 aa)
HELQHelicase POLQ-like isoform X1. (1104 aa)
FANCMFanconi anemia group M protein isoform X1. (2045 aa)
XRCC6X-ray repair cross-complementing protein 6 isoform X2. (609 aa)
MCM5DNA replication licensing factor MCM5-like. (734 aa)
DHX9ATP-dependent RNA helicase A isoform X1. (1153 aa)
SUPV3L1ATP-dependent RNA helicase SUPV3L1, mitochondrial isoform X1. (784 aa)
ASCC3Activating signal cointegrator 1 complex subunit 3 isoform X1. (2196 aa)
ERCC2TFIIH basal transcription factor complex helicase XPD subunit. (772 aa)
MCM4DNA helicase; Belongs to the MCM family. (692 aa)
RFC2Replication factor C subunit 2. (316 aa)
C17orf64LOW QUALITY PROTEIN: uncharacterized protein C17orf64 homolog. (261 aa)
DQX1ATP-dependent RNA helicase DQX1. (719 aa)
XRCC5X-ray repair cross-complementing protein 5 isoform X1. (733 aa)
HELBDNA helicase B. (1045 aa)
G3BP1Ras GTPase-activating protein-binding protein 1. (465 aa)
RECQL4ATP-dependent DNA helicase Q4. (1210 aa)
CHTF18Chromosome transmission fidelity protein 18 homolog. (1090 aa)
TM4SF19Transmembrane 4 L6 family member 19. (208 aa)
CHD3chromodomain-helicase-DNA-binding protein 3 isoform X1. (1963 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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