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| | BIVM | Basic immunoglobulin-like variable motif-containing protein isoform X3. (498 aa) |
| | WDR48 | WD repeat-containing protein 48 isoform X2. (677 aa) |
| | SMC2 | Structural maintenance of chromosomes protein. (1196 aa) |
| | TSN | Translin isoform X1. (228 aa) |
| | DMC1 | Meiotic recombination protein DMC1/LIM15 homolog; Belongs to the RecA family. (340 aa) |
| | PMS2 | Mismatch repair endonuclease PMS2 isoform X4. (863 aa) |
| | POLA1 | DNA polymerase. (1467 aa) |
| | SUB1 | Activated RNA polymerase II transcriptional coactivator p15. (103 aa) |
| | RAD51AP2 | RAD51-associated protein 2. (1114 aa) |
| | PCBP2 | LOW QUALITY PROTEIN: poly(RC)-binding protein 2-like. (366 aa) |
| | MCM2 | Minichromosome maintenance complex component 2. (905 aa) |
| | DHX36 | ATP-dependent RNA helicase DHX36 isoform X1. (1012 aa) |
| | HNRNPU | Heterogeneous nuclear ribonucleoprotein U isoform X1. (818 aa) |
| | RAD18 | E3 ubiquitin-protein ligase RAD18 isoform X2. (493 aa) |
| | POU4F1 | POU domain protein. (419 aa) |
| | SSBP4 | Single stranded DNA binding protein 4. (384 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (931 aa) |
| | ZRANB3 | DNA annealing helicase and endonuclease ZRANB3 isoform X1. (1078 aa) |
| | TERF1 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (406 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (801 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (820 aa) |
| | STN1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa) |
| | RECQL | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (649 aa) |
| | POT1 | Protection of telomeres protein 1 isoform X2. (634 aa) |
| | RTF1 | RNA polymerase-associated protein RTF1 homolog. (710 aa) |
| | RAD50 | DNA repair protein RAD50. (1267 aa) |
| | NUP35 | Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family. (279 aa) |
| | POLR2G | DNA-directed RNA polymerase II subunit RPB7. (172 aa) |
| | TERF2 | Telomeric repeat-binding factor 2 isoform X1. (500 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa) |
| | CTC1 | CST complex subunit CTC1. (1156 aa) |
| | SAMHD1 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1. (627 aa) |
| | SWSAP1 | ATPase SWSAP1. (229 aa) |
| | SPRTN | sprT-like domain-containing protein Spartan isoform X1. (426 aa) |
| | YBX1 | Nuclease-sensitive element-binding protein 1 isoform X1. (316 aa) |
| | FBH1 | F-box DNA helicase 1 isoform X2. (1074 aa) |
| | TERF2IP | Telomeric repeat-binding factor 2-interacting protein 1. (237 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa) |
| | SMC5 | Structural maintenance of chromosomes 5. (1050 aa) |
| | CRY2 | Cryptochrome-2. (593 aa) |
| | PURB | Transcriptional activator protein Pur-beta. (304 aa) |
| | NUCKS1 | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 isoform X1. (306 aa) |
| | HROB | Uncharacterized protein C17orf53 homolog. (645 aa) |
| | BRCA2 | Breast cancer type 2 susceptibility protein. (3307 aa) |
| | SMC4 | Structural maintenance of chromosomes protein. (1278 aa) |
| | SSBP1 | Single-stranded DNA-binding protein, mitochondrial isoform X2. (148 aa) |
| | RECQL4 | ATP-dependent DNA helicase Q4. (1210 aa) |
| | RBBP8 | DNA endonuclease RBBP8 isoform X2. (846 aa) |
| | ERCC4 | DNA repair endonuclease XPF. (914 aa) |
| | POLR3C | RNA polymerase III subunit C. (534 aa) |
| | MSH3 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1122 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (299 aa) |
| | MMS22L | Protein MMS22-like isoform X1. (1233 aa) |
| | BLM | Bloom syndrome protein isoform X1. (1409 aa) |
| | TDP2 | tyrosyl-DNA phosphodiesterase 2 isoform X2. (362 aa) |
| | SMC6 | Structural maintenance of chromosomes protein 6 isoform X1. (1097 aa) |
| | TEN1 | CST complex subunit TEN1. (124 aa) |
| | HMGB2 | High mobility group protein B2. (209 aa) |
| | RAD51B | DNA repair protein RAD51 homolog 2 isoform X2. (345 aa) |
| | RAD51D | DNA repair protein RAD51 homolog 4. (305 aa) |
| | HMCES | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (350 aa) |
| | FUBP3 | Far upstream element-binding protein 3 isoform X1. (571 aa) |
| | TWNK | Twinkle protein, mitochondrial. (683 aa) |
| | PCBP3 | poly(RC)-binding protein 3. (361 aa) |
| | RAD51AP1 | RAD51-associated protein 1 isoform X1. (345 aa) |
| | MCM10 | Protein MCM10 homolog. (872 aa) |
| | XPC | DNA repair protein complementing XP-C cells. (907 aa) |
| | POLR2H | DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa) |
| | MEIOB | Meiosis-specific with OB domain-containing protein isoform X1. (442 aa) |
| | PURA | Transcriptional activator protein Pur-alpha. (325 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (718 aa) |
| | MCM8 | DNA helicase MCM8 isoform X1; Belongs to the MCM family. (821 aa) |
| | NEIL3 | Endonuclease 8-like 3 isoform X1. (606 aa) |
| | SSBP3 | Single-stranded DNA-binding protein 3. (357 aa) |
| | TDP1 | tyrosyl-DNA phosphodiesterase 1 isoform X1. (601 aa) |
| | LONP1 | Lon peptidase 1, mitochondrial. (956 aa) |
| | RPA3 | Replication protein A 14 kDa subunit. (121 aa) |
| | IGHMBP2 | DNA-binding protein SMUBP-2. (980 aa) |
| | MCM9 | DNA helicase MCM9 isoform X4; Belongs to the MCM family. (696 aa) |
| | SSBP2 | Single-stranded DNA-binding protein 2. (369 aa) |
| | SHOC1 | Uncharacterized protein C9orf84 homolog. (1504 aa) |
| | MLH1 | DNA mismatch repair protein Mlh1 isoform X1. (689 aa) |
| | CDC45 | Cell division control protein 45 homolog. (567 aa) |
| | SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (944 aa) |
| | RAD52 | DNA repair protein RAD52 homolog isoform X5. (409 aa) |
| | JCHAIN | Immunoglobulin J chain isoform X2. (158 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (692 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (315 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1003 aa) |
| | MYEF2 | Myelin expression factor 2 isoform X1. (596 aa) |
| | NABP1 | SOSS complex subunit B2 isoform X1. (204 aa) |
| | REXO4 | RNA exonuclease 4. (339 aa) |
| | DHX9 | ATP-dependent RNA helicase A isoform X1. (1153 aa) |
| | RADX | Uncharacterized protein CXorf57 homolog isoform X2. (812 aa) |
| | RPA2 | Replication protein A 32 kDa subunit. (344 aa) |
| | APTX | Aprataxin isoform X1. (329 aa) |
| | MCM5 | DNA replication licensing factor MCM5-like. (734 aa) |
| | NABP2 | SOSS complex subunit B1. (211 aa) |
| | LRPPRC | Leucine-rich PPR motif-containing protein, mitochondrial isoform X1. (1393 aa) |
| | RAD54L | DNA repair and recombination protein RAD54-like isoform X2. (744 aa) |
| | ERCC5 | DNA repair protein complementing XP-G cells isoform X1. (1180 aa) |
