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| | ETAA1 | Ewing's tumor-associated antigen 1 isoform X2. (905 aa) |
| | TRAIP | E3 ubiquitin-protein ligase TRAIP. (471 aa) |
| | ATAD5 | ATPase family AAA domain-containing protein 5 isoform X1. (1830 aa) |
| | KIN | DNA/RNA-binding protein KIN17. (392 aa) |
| | POLA1 | DNA polymerase. (1467 aa) |
| | RRM1 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (791 aa) |
| | POLD3 | DNA polymerase delta subunit 3 isoform X1. (465 aa) |
| | POLD2 | DNA polymerase delta subunit 2. (469 aa) |
| | NFIX | Nuclear factor 1 X-type. (492 aa) |
| | PRIMPOL | DNA-directed primase/polymerase protein isoform X1. (490 aa) |
| | FANCM | Fanconi anemia group M protein isoform X1. (2045 aa) |
| | TIMELESS | Protein timeless homolog isoform X2. (1200 aa) |
| | MCM5 | DNA replication licensing factor MCM5-like. (734 aa) |
| | RPA2 | Replication protein A 32 kDa subunit. (344 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) |
| | DHX9 | ATP-dependent RNA helicase A isoform X1. (1153 aa) |
| | GRWD1 | Glutamate-rich WD repeat-containing protein 1. (446 aa) |
| | CCNE1 | G1/S-specific cyclin-E1; Belongs to the cyclin family. (350 aa) |
| | E4F1 | E4F transcription factor 1. (785 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (692 aa) |
| | GINS3 | DNA replication complex GINS protein PSF3. (216 aa) |
| | LIG1 | DNA ligase. (923 aa) |
| | RFC2 | Replication factor C subunit 2. (316 aa) |
| | POLG2 | DNA polymerase subunit gamma-2, mitochondrial isoform X2. (482 aa) |
| | POLG | DNA polymerase subunit gamma-1. (1229 aa) |
| | ORC3 | Origin recognition complex subunit 3 isoform X3. (714 aa) |
| | SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (944 aa) |
| | HELB | DNA helicase B. (1045 aa) |
| | MCMBP | Mini-chromosome maintenance complex-binding protein isoform X1. (642 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa) |
| | PCLAF | PCNA-associated factor. (96 aa) |
| | NFIC | Nuclear factor I C. (496 aa) |
| | POLK | DNA polymerase kappa. (871 aa) |
| | RECQL4 | ATP-dependent DNA helicase Q4. (1210 aa) |
| | SSBP1 | Single-stranded DNA-binding protein, mitochondrial isoform X2. (148 aa) |
| | POLE4 | LOW QUALITY PROTEIN: DNA polymerase epsilon subunit 4. (116 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (297 aa) |
| | NUCKS1 | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 isoform X1. (306 aa) |
| | BRCA2 | Breast cancer type 2 susceptibility protein. (3307 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa) |
| | NFIB | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (299 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2262 aa) |
| | ORC5 | Origin recognition complex subunit 5 isoform X1. (376 aa) |
| | MMS22L | Protein MMS22-like isoform X1. (1233 aa) |
| | RBMS1 | RNA-binding motif, single-stranded-interacting protein 1 isoform X8. (381 aa) |
| | MCM10 | Protein MCM10 homolog. (872 aa) |
| | NFIA | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (532 aa) |
| | SRPK2 | SRSF protein kinase 2 isoform X7. (691 aa) |
| | WDR18 | WD repeat domain 18. (418 aa) |
| | POLQ | DNA polymerase theta. (2722 aa) |
| | FBH1 | F-box DNA helicase 1 isoform X2. (1074 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa) |
| | POLE3 | DNA polymerase epsilon subunit 3. (147 aa) |
| | BAZ1A | Bromodomain adjacent to zinc finger domain protein 1A isoform X2. (1549 aa) |
| | PRIM2 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (347 aa) |
| | RFC5 | Replication factor C subunit 5. (341 aa) |
| | KAT7 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa) |
| | DSCC1 | Sister chromatid cohesion protein DCC1 isoform X1. (392 aa) |
| | RFWD3 | E3 ubiquitin-protein ligase RFWD3. (724 aa) |
| | EME1 | Crossover junction endonuclease EME1 isoform X1. (591 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | RFC3 | Replication factor C subunit 3 isoform X2. (355 aa) |
| | RBM48 | RNA-binding protein 48 isoform X2. (362 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (420 aa) |
| | PURA | Transcriptional activator protein Pur-alpha. (325 aa) |
| | SIN3A | Paired amphipathic helix protein Sin3a isoform X1. (1211 aa) |
| | UPF1 | Regulator of nonsense transcripts 1 isoform X2. (1112 aa) |
| | ZPR1 | Zinc finger protein ZPR1. (459 aa) |
| | ING4 | Inhibitor of growth protein. (247 aa) |
| | ORC2 | Origin recognition complex subunit 2 isoform X1. (496 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (700 aa) |
| | NASP | Nuclear autoantigenic sperm protein isoform X4. (788 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1377 aa) |
| | SIRT7 | NAD-dependent protein deacetylase sirtuin-7. (400 aa) |
| | WRN | Werner syndrome ATP-dependent helicase isoform X2. (1352 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (718 aa) |
| | DDX50 | ATP-dependent RNA helicase DDX50. (736 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | TM4SF19 | Transmembrane 4 L6 family member 19. (208 aa) |
| | TOPBP1 | DNA topoisomerase 2-binding protein 1-like isoform X2. (1520 aa) |
| | MCM8 | DNA helicase MCM8 isoform X1; Belongs to the MCM family. (821 aa) |
| | TBRG1 | Transforming growth factor beta regulator 1 isoform X1. (409 aa) |
| | DTD1 | D-aminoacyl-tRNA deacylase. (209 aa) |
| | NOC3L | Nucleolar complex protein 3 homolog. (800 aa) |
| | ORC6 | Origin recognition complex subunit 6. (252 aa) |
| | DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1. (1059 aa) |
| | RBBP7 | Histone-binding protein RBBP7 isoform X1. (469 aa) |
| | RPA3 | Replication protein A 14 kDa subunit. (121 aa) |
| | POLN | DNA polymerase nu. (895 aa) |
| | MCM9 | DNA helicase MCM9 isoform X4; Belongs to the MCM family. (696 aa) |
| | RFC1 | Replication factor C subunit 1-like isoform X1. (1149 aa) |
| | RPAIN | RPA-interacting protein isoform X2. (219 aa) |
| | LRWD1 | Leucine-rich repeat and WD repeat-containing protein 1. (647 aa) |
| | RTF2 | Protein RTF2 homolog isoform X1. (306 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa) |
| | CDC45 | Cell division control protein 45 homolog. (567 aa) |
| | ENSTTRP00000014196 | annotation not available (422 aa) |
| | TWNK | Twinkle protein, mitochondrial. (683 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (187 aa) |
| | ZNF830 | Zinc finger protein 830. (371 aa) |
| | LIG3 | DNA ligase. (1000 aa) |
| | TICRR | Treslin. (1890 aa) |
| | RECQL5 | ATP-dependent DNA helicase Q5 isoform X2. (946 aa) |
| | RRM2B | Ribonucleoside-diphosphate reductase subunit M2 B. (345 aa) |
| | GEN1 | Flap endonuclease GEN homolog 1. (907 aa) |
| | DERPC | LOW QUALITY PROTEIN: chromosome transmission fidelity protein 8 homolog. (450 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa) |
| | SUPT16H | FACT complex subunit SPT16 isoform X1. (1046 aa) |
| | CINP | Cyclin-dependent kinase 2-interacting protein. (212 aa) |
| | GMNN | Geminin. (210 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (828 aa) |
| | BLM | Bloom syndrome protein isoform X1. (1409 aa) |
| | DDX21 | Nucleolar RNA helicase 2. (783 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | MGME1 | Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair; Belongs to the MGME1 family. (343 aa) |
| | CDK9 | Cyclin-dependent kinase 9 isoform X1; Belongs to the protein kinase superfamily. (487 aa) |
| | THOC1 | THO complex subunit 1. (655 aa) |
| | RMI1 | recQ-mediated genome instability protein 1 isoform X1. (626 aa) |
| | RFC4 | Replication factor C subunit 4. (364 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (499 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (547 aa) |
| | SLX4 | Structure-specific endonuclease subunit SLX4. (1815 aa) |
| | MCM2 | Minichromosome maintenance complex component 2. (905 aa) |
| | LOC101316193 | DNA polymerase alpha subunit B isoform X2. (597 aa) |
| | KHDC3L | KHDC3-like protein. (218 aa) |
| | OOEP | Oocyte-expressed protein homolog isoform X2. (140 aa) |
| | ENSTTRP00000001484 | annotation not available (69 aa) |
| | RNASEH1 | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (286 aa) |
| | GINS1 | DNA replication complex GINS protein PSF1 isoform X3. (196 aa) |
| | CHAF1A | Chromatin assembly factor 1 subunit A. (940 aa) |
| | ENSTTRP00000001764 | annotation not available (98 aa) |
| | SAMHD1 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1. (627 aa) |
| | TONSL | Tonsoku-like protein. (1206 aa) |
| | SSRP1 | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (708 aa) |
| | PRIM1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (411 aa) |
| | POLD1 | LOW QUALITY PROTEIN: DNA polymerase delta catalytic subunit. (1125 aa) |
| | GMNC | Geminin coiled-coil domain-containing protein 1. (335 aa) |
| | REPIN1 | Replication initiator 1 isoform X3. (560 aa) |
| | RECQL | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (649 aa) |
| | WDHD1 | WD repeat and HMG-box DNA-binding protein 1 isoform X1. (1083 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (222 aa) |
| | RNASEH2A | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (213 aa) |
| | BOD1L1 | Biorientation of chromosomes in cell division protein 1-like 1 isoform X1. (2988 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (820 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (801 aa) |
| | WRNIP1 | ATPase WRNIP1 isoform X2. (391 aa) |
| | ZRANB3 | DNA annealing helicase and endonuclease ZRANB3 isoform X1. (1078 aa) |
| | TTC38 | Tetratricopeptide repeat protein 38. (458 aa) |
| | ATRX | Transcriptional regulator ATRX isoform X3. (2518 aa) |
| | CDT1 | DNA replication factor Cdt1. (372 aa) |
| | DDX23 | Probable ATP-dependent RNA helicase DDX23. (818 aa) |
| | TOP1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (841 aa) |
| | CCNE2 | G1/S-specific cyclin-E2; Belongs to the cyclin family. (404 aa) |
| | DONSON | Protein downstream neighbor of Son isoform X1. (457 aa) |
| | RMI2 | recQ-mediated genome instability protein 2. (77 aa) |
