20 items (Tursiops truncatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MCM3	DNA helicase; Belongs to the MCM family. (801 aa)
	MCM5	DNA replication licensing factor MCM5-like. (734 aa)
	MCM4	DNA helicase; Belongs to the MCM family. (692 aa)
	GINS3	DNA replication complex GINS protein PSF3. (216 aa)
	RECQL4	ATP-dependent DNA helicase Q4. (1210 aa)
	SSBP1	Single-stranded DNA-binding protein, mitochondrial isoform X2. (148 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
	MCM2	Minichromosome maintenance complex component 2. (905 aa)
	BLM	Bloom syndrome protein isoform X1. (1409 aa)
	GINS2	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
	RECQL5	ATP-dependent DNA helicase Q5 isoform X2. (946 aa)
	TWNK	Twinkle protein, mitochondrial. (683 aa)
	CDC45	Cell division control protein 45 homolog. (567 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (718 aa)
	WRN	Werner syndrome ATP-dependent helicase isoform X2. (1352 aa)
	PURA	Transcriptional activator protein Pur-alpha. (325 aa)
	RAD51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (299 aa)
	RECQL	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (649 aa)
	GINS4	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (222 aa)
	MCM6	DNA helicase; Belongs to the MCM family. (820 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BLM	CDC45	ENSTTRP00000015530	ENSTTRP00000014172	Bloom syndrome protein isoform X1.	Cell division control protein 45 homolog.	0.574
BLM	MCM2	ENSTTRP00000015530	ENSTTRP00000016215	Bloom syndrome protein isoform X1.	Minichromosome maintenance complex component 2.	0.542
BLM	MCM4	ENSTTRP00000015530	ENSTTRP00000007880	Bloom syndrome protein isoform X1.	DNA helicase; Belongs to the MCM family.	0.442
BLM	MCM5	ENSTTRP00000015530	ENSTTRP00000006946	Bloom syndrome protein isoform X1.	DNA replication licensing factor MCM5-like.	0.481
BLM	MCM6	ENSTTRP00000015530	ENSTTRP00000003455	Bloom syndrome protein isoform X1.	DNA helicase; Belongs to the MCM family.	0.422
BLM	RAD51	ENSTTRP00000015530	ENSTTRP00000010038	Bloom syndrome protein isoform X1.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.971
BLM	RECQL5	ENSTTRP00000015530	ENSTTRP00000015049	Bloom syndrome protein isoform X1.	ATP-dependent DNA helicase Q5 isoform X2.	0.571
BLM	RPA1	ENSTTRP00000015530	ENSTTRP00000001099	Bloom syndrome protein isoform X1.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.994
BLM	SSBP1	ENSTTRP00000015530	ENSTTRP00000009468	Bloom syndrome protein isoform X1.	Single-stranded DNA-binding protein, mitochondrial isoform X2.	0.407
BLM	WRN	ENSTTRP00000015530	ENSTTRP00000011670	Bloom syndrome protein isoform X1.	Werner syndrome ATP-dependent helicase isoform X2.	0.756
CDC45	BLM	ENSTTRP00000014172	ENSTTRP00000015530	Cell division control protein 45 homolog.	Bloom syndrome protein isoform X1.	0.574
CDC45	GINS2	ENSTTRP00000014172	ENSTTRP00000015177	Cell division control protein 45 homolog.	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family.	0.998
CDC45	GINS3	ENSTTRP00000014172	ENSTTRP00000008013	Cell division control protein 45 homolog.	DNA replication complex GINS protein PSF3.	0.996
CDC45	GINS4	ENSTTRP00000014172	ENSTTRP00000003336	Cell division control protein 45 homolog.	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family.	0.995
CDC45	MCM2	ENSTTRP00000014172	ENSTTRP00000016215	Cell division control protein 45 homolog.	Minichromosome maintenance complex component 2.	0.999
CDC45	MCM3	ENSTTRP00000014172	ENSTTRP00000003488	Cell division control protein 45 homolog.	DNA helicase; Belongs to the MCM family.	0.999
CDC45	MCM4	ENSTTRP00000014172	ENSTTRP00000007880	Cell division control protein 45 homolog.	DNA helicase; Belongs to the MCM family.	0.999
CDC45	MCM5	ENSTTRP00000014172	ENSTTRP00000006946	Cell division control protein 45 homolog.	DNA replication licensing factor MCM5-like.	0.999
CDC45	MCM6	ENSTTRP00000014172	ENSTTRP00000003455	Cell division control protein 45 homolog.	DNA helicase; Belongs to the MCM family.	0.999
CDC45	MCM7	ENSTTRP00000014172	ENSTTRP00000011680	Cell division control protein 45 homolog.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999