STRINGSTRING
GINS3 GINS3 MCM3 MCM3 MCM6 MCM6 GMNC GMNC ORC3 ORC3 LOC101316193 LOC101316193 PRIM1 PRIM1 PRIM2 PRIM2 MCM2 MCM2 CDC6 CDC6 ORC4 ORC4 ORC1 ORC1 CDC45 CDC45 ORC6 ORC6 NOC3L NOC3L MCM7 MCM7 TOPBP1 TOPBP1 MCM10 MCM10 CCNE2 CCNE2 POLA1 POLA1 MCM5 MCM5 ORC5 ORC5 CCNE1 CCNE1 MCM4 MCM4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GINS3DNA replication complex GINS protein PSF3. (216 aa)
MCM3DNA helicase; Belongs to the MCM family. (801 aa)
MCM6DNA helicase; Belongs to the MCM family. (820 aa)
GMNCGeminin coiled-coil domain-containing protein 1. (335 aa)
ORC3Origin recognition complex subunit 3 isoform X3. (714 aa)
LOC101316193DNA polymerase alpha subunit B isoform X2. (597 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (411 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (347 aa)
MCM2Minichromosome maintenance complex component 2. (905 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (499 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (828 aa)
CDC45Cell division control protein 45 homolog. (567 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
NOC3LNucleolar complex protein 3 homolog. (800 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (718 aa)
TOPBP1DNA topoisomerase 2-binding protein 1-like isoform X2. (1520 aa)
MCM10Protein MCM10 homolog. (872 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (404 aa)
POLA1DNA polymerase. (1467 aa)
MCM5DNA replication licensing factor MCM5-like. (734 aa)
ORC5Origin recognition complex subunit 5 isoform X1. (376 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (350 aa)
MCM4DNA helicase; Belongs to the MCM family. (692 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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