STRINGSTRING
AREG AREG FGF4 FGF4 FGF19 FGF19 FGF16 FGF16 HGF HGF FGF12 FGF12 BDNF BDNF FGF9 FGF9 TFF1 TFF1 GDF3 GDF3 IL7 IL7 NTF4 NTF4 PDGFB PDGFB ENSTTRP00000001241 ENSTTRP00000001241 MANF MANF LIF LIF OSM OSM JAG2 JAG2 THBS4 THBS4 PGF PGF GDNF GDNF BTC BTC CSPG5 CSPG5 EPGN EPGN EREG EREG IL11 IL11 BMP2 BMP2 IL5 IL5 IL4 IL4 PDGFA PDGFA NRG3 NRG3 NODAL NODAL INHBA INHBA LOC101324400 LOC101324400 BMP3 BMP3 GDF15 GDF15 CDNF CDNF EGF EGF FGF1 FGF1 VGF VGF VEGFC VEGFC FGF3 FGF3 HBEGF HBEGF BMP5 BMP5 IL34 IL34 IL12B IL12B VEGFD VEGFD FGF14 FGF14 TGFA TGFA ENSTTRP00000006594 ENSTTRP00000006594 CSF2 CSF2 ENSTTRP00000006798 ENSTTRP00000006798 ENSTTRP00000007089 ENSTTRP00000007089 RABEP2 RABEP2 CUNH17orf74 CUNH17orf74 FGF17 FGF17 ENSTTRP00000007731 ENSTTRP00000007731 OGN OGN GMFB GMFB FGF18 FGF18 CXCL12 CXCL12 AMBN AMBN PTN PTN FGF7 FGF7 VEGFA VEGFA IL6 IL6 FGF5 FGF5 BMP4 BMP4 IL12A IL12A BMP15 BMP15 NRTN NRTN CD320 CD320 GDF11 GDF11 ENSTTRP00000009289 ENSTTRP00000009289 TIMP1 TIMP1 ENSTTRP00000009655 ENSTTRP00000009655 VEGFB VEGFB FGF10 FGF10 PSPN PSPN NTF3 NTF3 FGF6 FGF6 PDGFC PDGFC NGF NGF NRG2 NRG2 LOC101325454 LOC101325454 GDF1 GDF1 INHA INHA GDF6 GDF6 ENSTTRP00000011729 ENSTTRP00000011729 FGF20 FGF20 TGFB1 TGFB1 CLEC11A CLEC11A INHBC INHBC INHBE INHBE OSGIN2 OSGIN2 FBRS FBRS GDF2 GDF2 GDF10 GDF10 BMP10 BMP10 ENSTTRP00000012880 ENSTTRP00000012880 TGFB2 TGFB2 MSTN MSTN ANGPTL3 ANGPTL3 IL2 IL2 INHBB INHBB IL9 IL9 FGF11 FGF11 ENSTTRP00000013510 ENSTTRP00000013510 LOC101327238 LOC101327238 HDGF HDGF FGF21 FGF21 FAM71F2 FAM71F2 FAM71F1 FAM71F1 GDF9 GDF9 RABEP1 RABEP1 PDGFD PDGFD FGF8 FGF8 MACC1 MACC1 NENF NENF TGFB3 TGFB3 IGF2 IGF2 BMP7 BMP7 PROK1 PROK1 BMP6 BMP6 FGF13 FGF13 ENSTTRP00000015206 ENSTTRP00000015206 KITLG KITLG CSF3 CSF3 GDF5 GDF5 OSGIN1 OSGIN1 IGF1 IGF1 TDGF1 TDGF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AREGAmphiregulin isoform X2. (253 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (147 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (116 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (727 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (255 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
TFF1Trefoil factor 1. (84 aa)
GDF3Growth/differentiation factor 3. (364 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (176 aa)
NTF4Neurotrophin 4. (210 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (240 aa)
ENSTTRP00000001241annotation not available (390 aa)
MANFLOW QUALITY PROTEIN: mesencephalic astrocyte-derived neurotrophic factor. (150 aa)
LIFLeukemia inhibitory factor. (202 aa)
OSMOncostatin M. (233 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1158 aa)
THBS4Thrombospondin-4. (948 aa)
PGFPlacenta growth factor; Belongs to the PDGF/VEGF growth factor family. (215 aa)
GDNFGlial cell line-derived neurotrophic factor isoform X2. (211 aa)
BTCProbetacellulin isoform X2. (178 aa)
CSPG5Chondroitin sulfate proteoglycan 5. (568 aa)
EPGNEpigen. (133 aa)
EREGProepiregulin isoform X2. (169 aa)
IL11Interleukin 11. (199 aa)
BMP2Bone morphogenetic protein 2. (388 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (135 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (134 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
NRG3Pro-neuregulin-3, membrane-bound isoform. (724 aa)
NODALNodal homolog. (348 aa)
INHBAInhibin beta A chain. (421 aa)
LOC101324400C-X-C motif chemokine. (104 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (475 aa)
GDF15Growth differentiation factor 15. (308 aa)
CDNFCerebral dopamine neurotrophic factor. (180 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1205 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
VGFVGF nerve growth factor inducible. (616 aa)
VEGFCVascular endothelial growth factor C isoform X1; Belongs to the PDGF/VEGF growth factor family. (420 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (159 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
BMP5Bone morphogenetic protein 5 isoform X2. (454 aa)
IL34Interleukin 34. (241 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
TGFAProtransforming growth factor alpha isoform X1. (224 aa)
ENSTTRP00000006594annotation not available (143 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (144 aa)
ENSTTRP00000006798annotation not available (130 aa)
ENSTTRP00000007089annotation not available (166 aa)
RABEP2Rabaptin, RAB GTPase binding effector protein 2. (533 aa)
CUNH17orf74Uncharacterized protein C17orf74 homolog. (451 aa)
FGF17Fibroblast growth factor 17. (216 aa)
ENSTTRP00000007731annotation not available (287 aa)
OGNMimecan. (299 aa)
GMFBGlia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (153 aa)
FGF18Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (207 aa)
CXCL12Stromal cell-derived factor 1 isoform X5; Belongs to the intercrine alpha (chemokine CxC) family. (138 aa)
AMBNAmeloblastin. (419 aa)
PTNPleiotrophin isoform X1. (249 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
VEGFAVascular endothelial growth factor A. (402 aa)
IL6Interleukin-6. (208 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (267 aa)
BMP4Bone morphogenetic protein 4. (407 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
BMP15Bone morphogenetic protein 15. (393 aa)
NRTNNeurturin. (197 aa)
CD320CD320 molecule. (266 aa)
GDF11Growth differentiation factor 11. (313 aa)
ENSTTRP00000009289annotation not available (304 aa)
TIMP1Metalloproteinase inhibitor 1 isoform X1. (196 aa)
ENSTTRP00000009655annotation not available (318 aa)
VEGFBVascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family. (172 aa)
FGF10Fibroblast growth factor 10. (142 aa)
PSPNPersephin. (153 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (252 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PDGFCPlatelet-derived growth factor C. (345 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
NRG2Neuregulin 2. (852 aa)
LOC101325454Bone morphogenetic protein 8B. (241 aa)
GDF1Embryonic growth/differentiation factor 1. (370 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (364 aa)
GDF6Growth/differentiation factor 6. (458 aa)
ENSTTRP00000011729annotation not available (367 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
TGFB1Transforming growth factor beta 1. (338 aa)
CLEC11AC-type lectin domain family 11 member A. (324 aa)
INHBCInhibin beta C chain. (247 aa)
INHBEInhibin subunit beta E. (351 aa)
OSGIN2Oxidative stress-induced growth inhibitor 2 isoform X1. (507 aa)
FBRSProbable fibrosin-1. (908 aa)
GDF2Growth/differentiation factor 2. (431 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (476 aa)
BMP10Bone morphogenetic protein 10. (423 aa)
ENSTTRP00000012880annotation not available (190 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (416 aa)
MSTNGrowth/differentiation factor 8. (375 aa)
ANGPTL3Angiopoietin like 3. (460 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
INHBBInhibin beta B chain. (407 aa)
IL9Interleukin-9. (141 aa)
FGF11Fibroblast growth factor 11. (124 aa)
ENSTTRP00000013510annotation not available (503 aa)
LOC101327238Left-right determination factor. (201 aa)
HDGFHeparin binding growth factor. (247 aa)
FGF21Fibroblast growth factor 21. (192 aa)
FAM71F2LOW QUALITY PROTEIN: protein FAM71F2. (308 aa)
FAM71F1Protein FAM71F1. (344 aa)
GDF9Growth/differentiation factor 9 isoform X1. (454 aa)
RABEP1Rab GTPase-binding effector protein 1 isoform X1. (860 aa)
PDGFDPlatelet-derived growth factor D isoform X1. (368 aa)
FGF8Fibroblast growth factor 8; Belongs to the heparin-binding growth factors family. (221 aa)
MACC1LOW QUALITY PROTEIN: metastasis-associated in colon cancer protein 1. (838 aa)
NENFNeudesin; Belongs to the cytochrome b5 family. (171 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (411 aa)
IGF2Insulin-like growth factor II. (184 aa)
BMP7Bone morphogenetic protein 7 isoform X2. (431 aa)
PROK1Prokineticin-1. (105 aa)
BMP6Bone morphogenetic protein 6. (304 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (259 aa)
ENSTTRP00000015206annotation not available (554 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
CSF3Colony stimulating factor 3. (207 aa)
GDF5Growth/differentiation factor 5. (489 aa)
OSGIN1Oxidative stress induced growth inhibitor 1. (488 aa)
IGF1Insulin-like growth factor 1 transcript variant X4. (194 aa)
TDGF1Teratocarcinoma-derived growth factor 1. (186 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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