(32 nodes) Response to gamma radiation network (Tursiops truncatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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protein homology

Your Input:
	BAK1	BCL2 antagonist/killer 1. (212 aa)
	ENSTTRP00000015784	annotation not available (149 aa)
	TIGAR	LOW QUALITY PROTEIN: fructose-2,6-bisphosphatase TIGAR-like. (269 aa)
	DCUN1D3	DCN1-like protein. (304 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa)
	MAP3K20	Mitogen-activated protein kinase kinase kinase MLT isoform X1. (800 aa)
	ERCC6	DNA excision repair protein ERCC-6 isoform X2. (1483 aa)
	APOBEC1	C->U-editing enzyme APOBEC-1 isoform X2. (187 aa)
	CDKN1A	Cyclin-dependent kinase inhibitor 1. (164 aa)
	LIG4	DNA ligase. (911 aa)
	TLK2	Serine/threonine-protein kinase tousled-like 2 isoform X4. (766 aa)
	WRN	Werner syndrome ATP-dependent helicase isoform X2. (1352 aa)
	CHEK2	Serine/threonine-protein kinase Chk2 isoform X2. (580 aa)
	YAP1	Transcriptional coactivator YAP1 isoform X4. (488 aa)
	HRAS	GTPase HRas isoform X1. (189 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (573 aa)
	BRCA2	Breast cancer type 2 susceptibility protein. (3307 aa)
	CRYAB	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
	ATR	Serine/threonine-protein kinase ATR isoform X2; Belongs to the PI3/PI4-kinase family. (2623 aa)
	XRCC5	X-ray repair cross-complementing protein 5 isoform X1. (733 aa)
	MEN1	Menin 1. (615 aa)
	KDM1A	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (869 aa)
	FANCD2	Fanconi anemia group D2 protein isoform X2. (1450 aa)
	XRCC6	X-ray repair cross-complementing protein 6 isoform X2. (609 aa)
	HSF1	Heat shock transcription factor 1. (476 aa)
	GTF2H5	General transcription factor IIH subunit 5. (71 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3043 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (509 aa)
	BCL2	Apoptosis regulator Bcl-2 isoform X1. (233 aa)
	XRCC2	DNA repair protein XRCC2 isoform X1. (267 aa)
	PML	Protein PML isoform X2. (871 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	ATR	ENSTTRP00000005735	ENSTTRP00000009512	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase ATR isoform X2; Belongs to the PI3/PI4-kinase family.	0.999
ATM	BCL2	ENSTTRP00000005735	ENSTTRP00000004766	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Apoptosis regulator Bcl-2 isoform X1.	0.564
ATM	BRCA2	ENSTTRP00000005735	ENSTTRP00000010004	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Breast cancer type 2 susceptibility protein.	0.918
ATM	CDKN1A	ENSTTRP00000005735	ENSTTRP00000012757	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin-dependent kinase inhibitor 1.	0.506
ATM	CHEK2	ENSTTRP00000005735	ENSTTRP00000011213	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase Chk2 isoform X2.	0.994
ATM	FANCD2	ENSTTRP00000005735	ENSTTRP00000007148	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Fanconi anemia group D2 protein isoform X2.	0.754
ATM	LIG4	ENSTTRP00000005735	ENSTTRP00000012005	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA ligase.	0.717
ATM	PRKAA1	ENSTTRP00000005735	ENSTTRP00000010343	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Non-specific serine/threonine protein kinase.	0.419
ATM	WRN	ENSTTRP00000005735	ENSTTRP00000011670	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Werner syndrome ATP-dependent helicase isoform X2.	0.990
ATM	XRCC2	ENSTTRP00000005735	ENSTTRP00000002529	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA repair protein XRCC2 isoform X1.	0.777
ATM	XRCC5	ENSTTRP00000005735	ENSTTRP00000008535	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	X-ray repair cross-complementing protein 5 isoform X1.	0.903
ATM	XRCC6	ENSTTRP00000005735	ENSTTRP00000006384	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	X-ray repair cross-complementing protein 6 isoform X2.	0.941
ATR	ATM	ENSTTRP00000009512	ENSTTRP00000005735	Serine/threonine-protein kinase ATR isoform X2; Belongs to the PI3/PI4-kinase family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.999
ATR	BRCA2	ENSTTRP00000009512	ENSTTRP00000010004	Serine/threonine-protein kinase ATR isoform X2; Belongs to the PI3/PI4-kinase family.	Breast cancer type 2 susceptibility protein.	0.444
ATR	CHEK2	ENSTTRP00000009512	ENSTTRP00000011213	Serine/threonine-protein kinase ATR isoform X2; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase Chk2 isoform X2.	0.994
ATR	ERCC6	ENSTTRP00000009512	ENSTTRP00000013957	Serine/threonine-protein kinase ATR isoform X2; Belongs to the PI3/PI4-kinase family.	DNA excision repair protein ERCC-6 isoform X2.	0.463
ATR	FANCD2	ENSTTRP00000009512	ENSTTRP00000007148	Serine/threonine-protein kinase ATR isoform X2; Belongs to the PI3/PI4-kinase family.	Fanconi anemia group D2 protein isoform X2.	0.816
ATR	LIG4	ENSTTRP00000009512	ENSTTRP00000012005	Serine/threonine-protein kinase ATR isoform X2; Belongs to the PI3/PI4-kinase family.	DNA ligase.	0.529
ATR	WRN	ENSTTRP00000009512	ENSTTRP00000011670	Serine/threonine-protein kinase ATR isoform X2; Belongs to the PI3/PI4-kinase family.	Werner syndrome ATP-dependent helicase isoform X2.	0.996
ATR	XRCC5	ENSTTRP00000009512	ENSTTRP00000008535	Serine/threonine-protein kinase ATR isoform X2; Belongs to the PI3/PI4-kinase family.	X-ray repair cross-complementing protein 5 isoform X1.	0.540