(25 nodes) Mesenchymal cell proliferation network (Tursiops truncatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (296 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (147 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	SIX2	Homeobox protein SIX2. (168 aa)
	HAND2	Heart- and neural crest derivatives-expressed protein 2. (208 aa)
	SHOX2	LOW QUALITY PROTEIN: short stature homeobox protein 2. (282 aa)
	PHF14	PHD finger protein 14 isoform X4. (945 aa)
	KDR	Vascular endothelial growth factor receptor 2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1307 aa)
	BMP2	Bone morphogenetic protein 2. (388 aa)
	TBX2	T-box transcription factor TBX2. (703 aa)
	DCHS1	Protocadherin-16. (3134 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (470 aa)
	SOX9	Transcription factor SOX-9. (509 aa)
	GPC3	Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (597 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	PRRX1	Paired mesoderm homeobox protein 1. (164 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	BMP4	Bone morphogenetic protein 4. (407 aa)
	OSR1	Protein odd-skipped-related 1. (267 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	MSX1	Homeobox protein MSX-1. (303 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (449 aa)
	SIX1	Homeobox protein SIX1. (284 aa)
	BMP7	Bone morphogenetic protein 7 isoform X2. (431 aa)
	DCHS2	Protocadherin-23. (2854 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP2	BMP4	ENSTTRP00000002383	ENSTTRP00000008787	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.899
BMP2	BMP7	ENSTTRP00000002383	ENSTTRP00000014836	Bone morphogenetic protein 2.	Bone morphogenetic protein 7 isoform X2.	0.719
BMP2	CTNNB1	ENSTTRP00000002383	ENSTTRP00000005764	Bone morphogenetic protein 2.	Catenin beta-1.	0.567
BMP2	FGF4	ENSTTRP00000002383	ENSTTRP00000000060	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.554
BMP2	FGF7	ENSTTRP00000002383	ENSTTRP00000008275	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.550
BMP2	FGF9	ENSTTRP00000002383	ENSTTRP00000000630	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.551
BMP2	SOX9	ENSTTRP00000002383	ENSTTRP00000005370	Bone morphogenetic protein 2.	Transcription factor SOX-9.	0.582
BMP4	BMP2	ENSTTRP00000008787	ENSTTRP00000002383	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.899
BMP4	BMP7	ENSTTRP00000008787	ENSTTRP00000014836	Bone morphogenetic protein 4.	Bone morphogenetic protein 7 isoform X2.	0.863
BMP4	CTNNB1	ENSTTRP00000008787	ENSTTRP00000005764	Bone morphogenetic protein 4.	Catenin beta-1.	0.688
BMP4	FGF4	ENSTTRP00000008787	ENSTTRP00000000060	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.735
BMP4	FGF7	ENSTTRP00000008787	ENSTTRP00000008275	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.658
BMP4	FGF9	ENSTTRP00000008787	ENSTTRP00000000630	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.684
BMP4	HAND2	ENSTTRP00000008787	ENSTTRP00000001282	Bone morphogenetic protein 4.	Heart- and neural crest derivatives-expressed protein 2.	0.523
BMP4	KDR	ENSTTRP00000008787	ENSTTRP00000002294	Bone morphogenetic protein 4.	Vascular endothelial growth factor receptor 2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.543
BMP4	MSX1	ENSTTRP00000008787	ENSTTRP00000011517	Bone morphogenetic protein 4.	Homeobox protein MSX-1.	0.636
BMP4	SHH	ENSTTRP00000008787	ENSTTRP00000013015	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.765
BMP4	SOX9	ENSTTRP00000008787	ENSTTRP00000005370	Bone morphogenetic protein 4.	Transcription factor SOX-9.	0.664
BMP4	WNT11	ENSTTRP00000008787	ENSTTRP00000012600	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.474
BMP4	WNT5A	ENSTTRP00000008787	ENSTTRP00000004970	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.591