STRINGSTRING
BRCC3 BRCC3 RAD9B RAD9B PHKG1 PHKG1 PKD2 PKD2 MAP3K20 MAP3K20 ZNF830 ZNF830 TICRR TICRR ENSTTRP00000014807 ENSTTRP00000014807 BMP7 BMP7 KANK2 KANK2 RFWD3 RFWD3 FBXO5 FBXO5 ATF2 ATF2 FOXN3 FOXN3 CLOCK CLOCK CDK1 CDK1 ATF5 ATF5 KAT2B KAT2B EIF2AK4 EIF2AK4 BUB1B BUB1B PML PML E2F7 E2F7 CHEK1 CHEK1 EME1 EME1 ENSTTRP00000014985 ENSTTRP00000014985 KNTC1 KNTC1 ORC1 ORC1 BUB3 BUB3 TP53BP1 TP53BP1 TAOK1 TAOK1 HORMAD1 HORMAD1 BLM BLM DCUN1D3 DCUN1D3 CDK5RAP3 CDK5RAP3 STK33 STK33 PASD1 PASD1 CDC6 CDC6 OVOL1 OVOL1 MUS81 MUS81 TPRA1 TPRA1 TRIM37 TRIM37 C10orf90 C10orf90 CCND1 CCND1 NME6 NME6 ATRIP ATRIP EZH2 EZH2 TIMELESS TIMELESS CDK5RAP2 CDK5RAP2 TNKS TNKS NABP2 NABP2 FHL1 FHL1 CDC5L CDC5L KAT2A KAT2A MDM1 MDM1 FBXO7 FBXO7 ZFP36L2 ZFP36L2 MAD2L1BP MAD2L1BP MACROH2A1 MACROH2A1 ATM ATM MTBP MTBP HASPIN HASPIN E2F8 E2F8 RHNO1 RHNO1 CTDSPL CTDSPL FOXO4 FOXO4 PLK1 PLK1 EEF1AKNMT EEF1AKNMT BCL2 BCL2 CRLF3 CRLF3 ABRAXAS1 ABRAXAS1 DONSON DONSON KLHL22 KLHL22 CDT1 CDT1 MRNIP MRNIP ATRX ATRX MSH2 MSH2 RB1 RB1 INHBA INHBA SYF2 SYF2 MIIP MIIP ZFP36L1 ZFP36L1 PLK3 PLK3 CRADD CRADD RAD1 RAD1 DOT1L DOT1L BABAM1 BABAM1 BUB1 BUB1 WAC WAC APBB2 APBB2 NEK11 NEK11 CCDC84 CCDC84 TTK TTK SMARCA5 SMARCA5 RAD17 RAD17 HINFP HINFP CHMP4C CHMP4C BAZ1B BAZ1B CCP110 CCP110 ZNF655 ZNF655 USP28 USP28 ZW10 ZW10 SUSD2 SUSD2 DTL DTL UIMC1 UIMC1 INTS7 INTS7 NEK2 NEK2 CHMP2A CHMP2A RAD21 RAD21 RBL1 RBL1 MFSD11 MFSD11 APC APC PINX1 PINX1 LIF LIF RINT1 RINT1 CCNF CCNF TRIM39 TRIM39 PPP1R10 PPP1R10 PRKDC PRKDC CTDSP2 CTDSP2 FZR1 FZR1 FBXO31 FBXO31 DACT1 DACT1 GPNMB GPNMB TRIP13 TRIP13 PTPN11 PTPN11 BMP4 BMP4 INIP INIP CDC73 CDC73 FAM122A FAM122A DAB2IP DAB2IP MUC1 MUC1 VPS4A VPS4A ATR ATR E2F1 E2F1 NAE1 NAE1 TIPIN TIPIN ZWILCH ZWILCH AURKB AURKB IK IK USP47 USP47 MRE11 MRE11 CHFR CHFR MAD1L1 MAD1L1 CASP2 CASP2 BIRC5 BIRC5 MAD2L1 MAD2L1 XPC XPC ZNF207 ZNF207 EME2 EME2 ZFYVE19 ZFYVE19 IZUMO4 IZUMO4 PTTG1 PTTG1 BRCA1 BRCA1 CHEK2 CHEK2 JADE1 JADE1 CLSPN CLSPN PLK5 PLK5 CDKN2D CDKN2D NABP1 NABP1 WAPL WAPL FANCD2 FANCD2 FBXO43 FBXO43 NAA10 NAA10 NACC2 NACC2 AVEN AVEN NOP53 NOP53 TOM1L1 TOM1L1 TPR TPR PSMG2 PSMG2 NKX3-1 NKX3-1 SDE2 SDE2 DLG1 DLG1 PIDD1 PIDD1 TMEM67 TMEM67 PRPF19 PRPF19 BABAM2 BABAM2 NSUN2 NSUN2 RBL2 RBL2 TOPBP1 TOPBP1 CTDSP1 CTDSP1 NBN NBN TAOK3 TAOK3 RAD9A RAD9A CDK2AP2 CDK2AP2 DNA2 DNA2 HUS1 HUS1 BRD7 BRD7 CDKN1A CDKN1A DMRT1 DMRT1 TIPRL TIPRL NANOS2 NANOS2 CCL2 CCL2 SPDL1 SPDL1 DLG2 DLG2 ERCC6 ERCC6 INTS3 INTS3 TOM1L2 TOM1L2 CDKN1B CDKN1B C10orf99 C10orf99
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BRCC3Lys-63-specific deubiquitinase BRCC36 isoform X1. (317 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (420 aa)
PHKG1Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X2; Belongs to the protein kinase superfamily. (390 aa)
PKD2Polycystin-2 isoform X2. (975 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase MLT isoform X1. (800 aa)
ZNF830Zinc finger protein 830. (371 aa)
TICRRTreslin. (1890 aa)
ENSTTRP00000014807annotation not available (320 aa)
BMP7Bone morphogenetic protein 7 isoform X2. (431 aa)
KANK2KN motif and ankyrin repeat domain-containing protein 2. (739 aa)
RFWD3E3 ubiquitin-protein ligase RFWD3. (724 aa)
FBXO5F-box only protein 5 isoform X1. (448 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
FOXN3Forkhead box protein N3 isoform X4. (488 aa)
CLOCKCircadian locomoter output cycles protein kaput. (845 aa)
CDK1Cyclin-dependent kinase 1 isoform X3; Belongs to the protein kinase superfamily. (301 aa)
ATF5Activating transcription factor 5. (278 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (731 aa)
EIF2AK4eIF-2-alpha kinase GCN2 isoform X1. (1649 aa)
BUB1BMitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform X1. (1051 aa)
PMLProtein PML isoform X2. (871 aa)
E2F7Transcription factor E2F7. (904 aa)
CHEK1Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily. (475 aa)
EME1Crossover junction endonuclease EME1 isoform X1. (591 aa)
ENSTTRP00000014985annotation not available (90 aa)
KNTC1Kinetochore-associated protein 1. (2203 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (828 aa)
BUB3Mitotic checkpoint protein BUB3 isoform X1. (328 aa)
TP53BP1Tumor suppressor p53-binding protein 1 isoform X1. (1972 aa)
TAOK1Serine/threonine-protein kinase TAO1. (1000 aa)
HORMAD1HORMA domain-containing protein 1. (393 aa)
BLMBloom syndrome protein isoform X1. (1409 aa)
DCUN1D3DCN1-like protein. (304 aa)
CDK5RAP3CDK5 regulatory subunit-associated protein 3 isoform X1. (505 aa)
STK33Serine/threonine-protein kinase 33 isoform X1. (474 aa)
PASD1Circadian clock protein PASD1. (620 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (499 aa)
OVOL1Ovo like transcriptional repressor 1. (267 aa)
MUS81MUS81 structure-specific endonuclease subunit. (547 aa)
TPRA1Transmembrane protein adipocyte-associated 1. (361 aa)
TRIM37E3 ubiquitin-protein ligase TRIM37 isoform X2. (962 aa)
C10orf90Centrosomal protein C10orf90 homolog. (697 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
NME6Nucleoside diphosphate kinase. (194 aa)
ATRIPATR-interacting protein isoform X1. (790 aa)
EZH2Histone-lysine N-methyltransferase EZH2 isoform X2. (751 aa)
TIMELESSProtein timeless homolog isoform X2. (1200 aa)
CDK5RAP2LOW QUALITY PROTEIN: CDK5 regulatory subunit-associated protein 2. (1890 aa)
TNKSPoly [ADP-ribose] polymerase. (1312 aa)
NABP2SOSS complex subunit B1. (211 aa)
FHL1Four and a half LIM domains protein 1 isoform X1. (323 aa)
CDC5LCell division cycle 5-like protein isoform X1. (801 aa)
KAT2AHistone acetyltransferase KAT2A. (835 aa)
MDM1Nuclear protein MDM1 isoform X3. (675 aa)
FBXO7LOW QUALITY PROTEIN: F-box only protein 7-like. (513 aa)
ZFP36L2mRNA decay activator protein ZFP36L2. (494 aa)
MAD2L1BPMAD2L1-binding protein. (256 aa)
MACROH2A1Histone H2A; Belongs to the histone H2A family. (372 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3043 aa)
MTBPMdm2-binding protein isoform X2. (903 aa)
HASPINSerine/threonine-protein kinase haspin. (782 aa)
E2F8Transcription factor E2F8 isoform X1. (866 aa)
RHNO1RAD9, HUS1, RAD1-interacting nuclear orphan protein 1. (240 aa)
CTDSPLCTD small phosphatase-like protein isoform X4. (235 aa)
FOXO4Forkhead box O4. (511 aa)
PLK1Serine/threonine-protein kinase PLK. (602 aa)
EEF1AKNMTMethyltransferase-like protein 13 isoform X1. (699 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
CRLF3Cytokine receptor-like factor 3. (441 aa)
ABRAXAS1BRCA1-A complex subunit Abraxas isoform X1. (410 aa)
DONSONProtein downstream neighbor of Son isoform X1. (457 aa)
KLHL22Kelch-like protein 22 isoform X3. (558 aa)
CDT1DNA replication factor Cdt1. (372 aa)
MRNIPUPF0544 protein C5orf45 homolog isoform X4. (339 aa)
ATRXTranscriptional regulator ATRX isoform X3. (2518 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (931 aa)
RB1Retinoblastoma-associated protein. (922 aa)
INHBAInhibin beta A chain. (421 aa)
SYF2pre-mRNA-splicing factor SYF2. (244 aa)
MIIPMigration and invasion-inhibitory protein isoform X2. (376 aa)
ZFP36L1mRNA decay activator protein ZFP36L1. (338 aa)
PLK3Serine/threonine-protein kinase PLK. (639 aa)
CRADDDeath domain-containing protein CRADD isoform X1. (199 aa)
RAD1Cell cycle checkpoint protein RAD1 isoform X1. (278 aa)
DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specific isoform X2. (1705 aa)
BABAM1BRISC and BRCA1-A complex member 1 isoform X1. (367 aa)
BUB1Mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1. (1083 aa)
WACWW domain-containing adapter protein with coiled-coil isoform X3. (635 aa)
APBB2Amyloid beta A4 precursor protein-binding family B member 2 isoform X2. (749 aa)
NEK11NIMA related kinase 11. (642 aa)
CCDC84Coiled-coil domain-containing protein 84 isoform X2. (321 aa)
TTKDual specificity protein kinase TTK isoform X1. (856 aa)
SMARCA5SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5. (983 aa)
RAD17Cell cycle checkpoint protein RAD17. (683 aa)
HINFPHistone H4 transcription factor. (520 aa)
CHMP4CCharged multivesicular body protein 4c. (237 aa)
BAZ1BTyrosine-protein kinase BAZ1B. (1482 aa)
CCP110Centriolar coiled-coil protein of 110 kDa isoform X1. (1013 aa)
ZNF655Zinc finger protein 655 isoform X3. (490 aa)
USP28Ubiquitin carboxyl-terminal hydrolase 28 isoform X7; Belongs to the peptidase C19 family. (1080 aa)
ZW10Centromere/kinetochore protein zw10 homolog. (730 aa)
SUSD2Sushi domain-containing protein 2. (820 aa)
DTLDenticleless protein homolog isoform X3. (730 aa)
UIMC1BRCA1-A complex subunit RAP80 isoform X1. (720 aa)
INTS7Integrator complex subunit 7. (930 aa)
NEK2Serine/threonine-protein kinase Nek2. (445 aa)
CHMP2ACharged multivesicular body protein 2a isoform X2. (222 aa)
RAD21Double-strand-break repair protein rad21 homolog isoform X1. (630 aa)
RBL1Retinoblastoma-like protein 1 isoform X2. (1067 aa)
MFSD11UNC93-like protein MFSD11. (449 aa)
APCAdenomatous polyposis coli protein isoform X2. (2845 aa)
PINX1PIN2/TERF1-interacting telomerase inhibitor 1. (312 aa)
LIFLeukemia inhibitory factor. (202 aa)
RINT1RAD50-interacting protein 1 isoform X1. (792 aa)
CCNFcyclin-F isoform X1. (785 aa)
TRIM39E3 ubiquitin-protein ligase TRIM39 isoform X1. (515 aa)
PPP1R10LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 1 regulatory subunit 10-like. (906 aa)
PRKDCDNA-dependent protein kinase catalytic subunit-like isoform X2; Belongs to the PI3/PI4-kinase family. (4120 aa)
CTDSP2Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2. (241 aa)
FZR1Fizzy-related protein homolog. (494 aa)
FBXO31F-box only protein 31 isoform X1. (428 aa)
DACT1Dapper homolog 1. (745 aa)
GPNMBTransmembrane glycoprotein NMB. (559 aa)
TRIP13Pachytene checkpoint protein 2 homolog. (434 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
BMP4Bone morphogenetic protein 4. (407 aa)
INIPSOSS complex subunit C isoform X1. (151 aa)
CDC73Parafibromin. (530 aa)
FAM122AProtein FAM122A. (290 aa)
DAB2IPDAB2 interacting protein. (1177 aa)
MUC1Mucin 1, cell surface associated. (443 aa)
VPS4AVacuolar protein sorting-associated protein 4A isoform X1; Belongs to the AAA ATPase family. (433 aa)
ATRSerine/threonine-protein kinase ATR isoform X2; Belongs to the PI3/PI4-kinase family. (2623 aa)
E2F1Transcription factor E2F1 isoform X1. (437 aa)
NAE1NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (537 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (297 aa)
ZWILCHProtein zwilch homolog isoform X2. (585 aa)
AURKBAurora kinase B isoform X4; Belongs to the protein kinase superfamily. (250 aa)
IKProtein Red. (551 aa)
USP47Ubiquitin carboxyl-terminal hydrolase 47 isoform X1; Belongs to the peptidase C19 family. (1362 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa)
CHFRE3 ubiquitin-protein ligase CHFR isoform X1. (661 aa)
MAD1L1Mitotic spindle assembly checkpoint protein MAD1 isoform X1. (755 aa)
CASP2Caspase-2 isoform X2; Belongs to the peptidase C14A family. (452 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (141 aa)
MAD2L1Mitotic spindle assembly checkpoint protein MAD2A. (205 aa)
XPCDNA repair protein complementing XP-C cells. (907 aa)
ZNF207BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform X2. (492 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (420 aa)
ZFYVE19abscission/NoCut checkpoint regulator. (461 aa)
IZUMO4IZUMO family member 4. (259 aa)
PTTG1Securin isoform X1. (202 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1825 aa)
CHEK2Serine/threonine-protein kinase Chk2 isoform X2. (580 aa)
JADE1Protein Jade-1 isoform X1. (841 aa)
CLSPNClaspin. (1331 aa)
PLK5Polo like kinase 5. (335 aa)
CDKN2DCyclin-dependent kinase 4 inhibitor D. (161 aa)
NABP1SOSS complex subunit B2 isoform X1. (204 aa)
WAPLWings apart-like protein homolog isoform X1. (1270 aa)
FANCD2Fanconi anemia group D2 protein isoform X2. (1450 aa)
FBXO43F-box only protein 43 isoform X2. (674 aa)
NAA10N-alpha-acetyltransferase 10. (228 aa)
NACC2Nucleus accumbens-associated protein 2. (418 aa)
AVENCell death regulator Aven. (353 aa)
NOP53NOP53 ribosome biogenesis factor. (485 aa)
TOM1L1TOM1-like protein 1; Belongs to the TOM1 family. (476 aa)
TPRNucleoprotein TPR isoform X3. (2361 aa)
PSMG2Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. Belongs to the PSMG2 family. (264 aa)
NKX3-1Homeobox protein Nkx-3.1. (138 aa)
SDE2Protein SDE2 homolog isoform X1. (418 aa)
DLG1Disks large homolog 1 isoform X3; Belongs to the MAGUK family. (920 aa)
PIDD1P53-induced death domain-containing protein 1. (913 aa)
TMEM67Meckelin isoform X1. (994 aa)
PRPF19pre-mRNA-processing factor 19. (503 aa)
BABAM2BRCA1-A complex subunit BRE. (411 aa)
NSUN2tRNA (Cytosine(34)-C(5))-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (760 aa)
RBL2Retinoblastoma-like protein 2. (1140 aa)
TOPBP1DNA topoisomerase 2-binding protein 1-like isoform X2. (1520 aa)
CTDSP1Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1. (261 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (746 aa)
TAOK3Serine/threonine-protein kinase TAO3 isoform X1. (887 aa)
RAD9ARAD9 checkpoint clamp component A. (390 aa)
CDK2AP2Cyclin-dependent kinase 2-associated protein; Belongs to the CDK2AP family. (117 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1. (1059 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (262 aa)
BRD7Bromodomain-containing protein 7 isoform X1. (635 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
DMRT1Doublesex- and mab-3-related transcription factor 1. (374 aa)
TIPRLTIP41-like protein isoform X1. (272 aa)
NANOS2Nanos homolog 2; Belongs to the nanos family. (138 aa)
CCL2C-C motif chemokine. (99 aa)
SPDL1Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. (603 aa)
DLG2Disks large homolog 2 isoform X2. (966 aa)
ERCC6DNA excision repair protein ERCC-6 isoform X2. (1483 aa)
INTS3Integrator complex subunit 3. (1038 aa)
TOM1L2TOM1-like protein 2 isoform X2; Belongs to the TOM1 family. (433 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (173 aa)
C10orf99Chromosome 10 open reading frame 99. (81 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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