(114 nodes) Positive regulation of endopeptidase activity network (Tursiops truncatus)

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Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	COL4A3	Collagen alpha-3(IV) chain. (1658 aa)
	TNFSF15	Tumor necrosis factor ligand superfamily member 15 isoform X1. (250 aa)
	SENP1	Sentrin-specific protease 1 isoform X2. (673 aa)
	ENSTTRP00000014732	annotation not available (304 aa)
	ACVR1C	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (492 aa)
	CASP9	Caspase-9; Belongs to the peptidase C14A family. (365 aa)
	DIABLO	Diablo homolog, mitochondrial isoform X1. (237 aa)
	ENSTTRP00000015007	annotation not available (215 aa)
	HIP1R	Huntingtin interacting protein 1 related. (1030 aa)
	ENSTTRP00000015100	annotation not available (189 aa)
	EFNA1	ephrin-A1 isoform X2; Belongs to the ephrin family. (205 aa)
	EFNA3	Ephrin A3. (238 aa)
	SIRT1	NAD-dependent protein deacetylase sirtuin-1 isoform X1. (616 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa)
	IFT57	Intraflagellar transport protein 57 homolog. (427 aa)
	CTSH	Cathepsin H. (335 aa)
	USP50	Inactive ubiquitin carboxyl-terminal hydrolase 50; Belongs to the peptidase C19 family. (337 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	LYN	Tyrosine-protein kinase. (491 aa)
	S100A8	Protein S100; Belongs to the S-100 family. (89 aa)
	S100A9	Protein S100-A9; Belongs to the S-100 family. (112 aa)
	PML	Protein PML isoform X2. (871 aa)
	XDH	Xanthine dehydrogenase/oxidase. (1332 aa)
	NLRC4	NLR family CARD domain-containing protein 4 isoform X1. (1025 aa)
	EPHA4	Ephrin type-A receptor 4 isoform X1. (979 aa)
	LAPTM5	Lysosomal-associated transmembrane protein 5. (264 aa)
	HIP1	Huntingtin-interacting protein 1. (1024 aa)
	NEK5	Serine/threonine-protein kinase Nek5; Belongs to the protein kinase superfamily. (682 aa)
	BAX	Apoptosis regulator BAX. (198 aa)
	BCL10	B-cell lymphoma/leukemia 10. (233 aa)
	CYR61	Protein CYR61. (382 aa)
	LGMN	Legumain. (433 aa)
	TBC1D10A	TBC1 domain family member 10A. (513 aa)
	PICALM	Phosphatidylinositol-binding clathrin assembly protein isoform X6. (660 aa)
	ACER2	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
	NCSTN	Nicastrin isoform X1. (709 aa)
	DDX3X	ATP-dependent RNA helicase DDX3X; Belongs to the DEAD box helicase family. (645 aa)
	MTCH1	Mitochondrial carrier homolog 1-like; Belongs to the mitochondrial carrier (TC 2.A.29) family. (389 aa)
	ENSTTRP00000002090	annotation not available (193 aa)
	MAP3K5	Mitogen-activated protein kinase kinase kinase 5 isoform X2. (1362 aa)
	TFAP4	Transcription factor AP-4. (333 aa)
	SMAD3	Mothers against decapentaplegic homolog 3. (291 aa)
	NODAL	Nodal homolog. (348 aa)
	MBP	Myelin basic protein. (281 aa)
	CYFIP2	Cytoplasmic FMR1-interacting protein 2. (1278 aa)
	CRADD	Death domain-containing protein CRADD isoform X1. (199 aa)
	SYK	Tyrosine-protein kinase. (629 aa)
	REST	RE1-silencing transcription factor. (656 aa)
	PSENEN	Gamma-secretase subunit PEN-2 isoform X1. (101 aa)
	AIFM1	Apoptosis inducing factor mitochondria associated 1. (613 aa)
	CASP8AP2	CASP8-associated protein 2 isoform X2. (1962 aa)
	DLC1	Rho GTPase-activating protein 7. (1525 aa)
	PDCD5	Programmed cell death protein 5. (125 aa)
	GRAMD4	GRAM domain-containing protein 4. (521 aa)
	SFRP2	Secreted frizzled-related protein 2. (294 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1246 aa)
	FIS1	Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
	MUL1	Mitochondrial ubiquitin ligase activator of NFKB 1. (352 aa)
	APH1A	Aph-1 homolog A, gamma-secretase subunit. (265 aa)
	ASPH	Aspartyl/asparaginyl beta-hydroxylase isoform X2. (750 aa)
	GSN	Gelsolin. (770 aa)
	CLEC7A	C-type lectin domain family 7 member A isoform X1. (243 aa)
	RPS3	40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
	P2RX1	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
	ATP2A3	Sarcoplasmic/endoplasmic reticulum calcium ATPase 3; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1060 aa)
	ENSTTRP00000005668	annotation not available (168 aa)
	BCL2L11	Bcl-2-like protein 11 isoform X1. (196 aa)
	TTBK1	Tau-tubulin kinase 1. (1316 aa)
	PSMD14	26S proteasome non-ATPase regulatory subunit 14. (294 aa)
	ENSTTRP00000006381	annotation not available (382 aa)
	APH1B	Gamma-secretase subunit APH-1B isoform X1. (159 aa)
	BAK1	BCL2 antagonist/killer 1. (212 aa)
	STAT3	Signal transducer and activator of transcription. (767 aa)
	F2R	Proteinase-activated receptor 1 isoform X1; Belongs to the G-protein coupled receptor 1 family. (426 aa)
	CARD9	Caspase recruitment domain-containing protein 9. (539 aa)
	PPM1F	Protein phosphatase 1F. (414 aa)
	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1. (758 aa)
	CFLAR	CASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family. (482 aa)
	CASP10	Caspase-10; Belongs to the peptidase C14A family. (515 aa)
	NGFR	Tumor necrosis factor receptor superfamily member 16. (427 aa)
	FAS	Tumor necrosis factor receptor superfamily member 6 isoform X2. (350 aa)
	RACK1	Receptor of activated protein C kinase 1. (346 aa)
	F3	Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (291 aa)
	PSME1	Proteasome activator complex subunit 1. (248 aa)
	PSME2	Proteasome activator complex subunit 2. (248 aa)
	CIDEB	Cell death activator CIDE-B. (220 aa)
	CASP8	Caspase-8 isoform X2; Belongs to the peptidase C14A family. (491 aa)
	ROBO1	Roundabout homolog 1 isoform X4. (1622 aa)
	PRELID1	PRELI domain-containing protein 1, mitochondrial. (219 aa)
	PRR7	Proline-rich protein 7. (267 aa)
	LCK	Tyrosine-protein kinase Lck. (536 aa)
	BOK	Bcl-2-related ovarian killer protein isoform X2. (137 aa)
	NDUFA13	LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13. (227 aa)
	YJEFN3	YjeF N-terminal domain containing 3. (303 aa)
	BAD	BCL2 associated agonist of cell death. (150 aa)
	EGLN3	Egl nine homolog 3. (319 aa)
	CASP2	Caspase-2 isoform X2; Belongs to the peptidase C14A family. (452 aa)
	ANP32B	Acidic leucine-rich nuclear phosphoprotein 32 family member B. (235 aa)
	LOC101333926	RE1-silencing transcription factor-like. (974 aa)
	ADRM1	Proteasomal ubiquitin receptor ADRM1. (406 aa)
	NOD1	Nucleotide-binding oligomerization domain-containing protein 1 isoform X1. (953 aa)
	VSIR	V-set immunoregulatory receptor. (310 aa)
	BCAP31	B-cell receptor-associated protein 31 isoform X2. (245 aa)
	PSME3	Proteasome activator subunit 3. (268 aa)
	NKX3-1	Homeobox protein Nkx-3.1. (138 aa)
	PIDD1	P53-induced death domain-containing protein 1. (913 aa)
	HTRA2	Serine protease HTRA2, mitochondrial. (457 aa)
	DAPK1	Death-associated protein kinase 1 isoform X2. (1449 aa)
	TNFSF10	Tumor necrosis factor ligand superfamily member. (298 aa)
	FAM162A	Protein FAM162A. (141 aa)
	NLRP6	NLR family pyrin domain containing 6. (873 aa)
	AGER	Advanced glycosylation end-product specific receptor. (418 aa)
	UACA	Uveal autoantigen with coiled-coil domains and ankyrin repeats isoform X1. (1416 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2. (538 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVR1C	NODAL	ENSTTRP00000014763	ENSTTRP00000002983	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Nodal homolog.	0.861
ACVR1C	SMAD3	ENSTTRP00000014763	ENSTTRP00000002846	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Mothers against decapentaplegic homolog 3.	0.928
ADRM1	HTRA2	ENSTTRP00000010513	ENSTTRP00000012074	Proteasomal ubiquitin receptor ADRM1.	Serine protease HTRA2, mitochondrial.	0.607
ADRM1	PSMD14	ENSTTRP00000010513	ENSTTRP00000006276	Proteasomal ubiquitin receptor ADRM1.	26S proteasome non-ATPase regulatory subunit 14.	0.970
ADRM1	PSME1	ENSTTRP00000010513	ENSTTRP00000008171	Proteasomal ubiquitin receptor ADRM1.	Proteasome activator complex subunit 1.	0.656
ADRM1	PSME2	ENSTTRP00000010513	ENSTTRP00000008173	Proteasomal ubiquitin receptor ADRM1.	Proteasome activator complex subunit 2.	0.717
ADRM1	PSME3	ENSTTRP00000010513	ENSTTRP00000011119	Proteasomal ubiquitin receptor ADRM1.	Proteasome activator subunit 3.	0.779
AGER	S100A9	ENSTTRP00000013075	ENSTTRP00000000015	Advanced glycosylation end-product specific receptor.	Protein S100-A9; Belongs to the S-100 family.	0.613
AGER	SYK	ENSTTRP00000013075	ENSTTRP00000003313	Advanced glycosylation end-product specific receptor.	Tyrosine-protein kinase.	0.519
AIFM1	BAK1	ENSTTRP00000003641	ENSTTRP00000006555	Apoptosis inducing factor mitochondria associated 1.	BCL2 antagonist/killer 1.	0.697
AIFM1	BAX	ENSTTRP00000003641	ENSTTRP00000001176	Apoptosis inducing factor mitochondria associated 1.	Apoptosis regulator BAX.	0.901
AIFM1	BCL2L11	ENSTTRP00000003641	ENSTTRP00000005763	Apoptosis inducing factor mitochondria associated 1.	Bcl-2-like protein 11 isoform X1.	0.491
AIFM1	CASP9	ENSTTRP00000003641	ENSTTRP00000014940	Apoptosis inducing factor mitochondria associated 1.	Caspase-9; Belongs to the peptidase C14A family.	0.418
AIFM1	DIABLO	ENSTTRP00000003641	ENSTTRP00000014965	Apoptosis inducing factor mitochondria associated 1.	Diablo homolog, mitochondrial isoform X1.	0.427
AIFM1	TNFSF15	ENSTTRP00000003641	ENSTTRP00000014621	Apoptosis inducing factor mitochondria associated 1.	Tumor necrosis factor ligand superfamily member 15 isoform X1.	0.403
APAF1	BAK1	ENSTTRP00000004494	ENSTTRP00000006555	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 antagonist/killer 1.	0.792
APAF1	BAX	ENSTTRP00000004494	ENSTTRP00000001176	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Apoptosis regulator BAX.	0.744
APAF1	BCL2L11	ENSTTRP00000004494	ENSTTRP00000005763	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Bcl-2-like protein 11 isoform X1.	0.435
APAF1	BOK	ENSTTRP00000004494	ENSTTRP00000009298	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Bcl-2-related ovarian killer protein isoform X2.	0.671
APAF1	CASP10	ENSTTRP00000004494	ENSTTRP00000007378	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-10; Belongs to the peptidase C14A family.	0.896