(67 nodes) Erythrocyte differentiation network (Tursiops truncatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	G6PD	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (552 aa)
	SRF	Serum response factor isoform X2. (509 aa)
	ZBTB7A	Zinc finger and BTB domain containing 7A. (587 aa)
	STAT5B	Signal transducer and activator of transcription. (787 aa)
	ENSTTRP00000006141	annotation not available (161 aa)
	NCAPG2	Condensin-2 complex subunit G2. (1142 aa)
	KCNQ1	Potassium voltage-gated channel subfamily KQT member 1. (673 aa)
	KIT	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (953 aa)
	MAEA	Macrophage erythroblast attacher. (373 aa)
	ZFPM1	Zinc finger protein ZFPM1. (984 aa)
	MPIG6B	Megakaryocyte and platelet inhibitory receptor G6b. (239 aa)
	ADAR	Double-stranded RNA-specific adenosine deaminase isoform X2. (1260 aa)
	FLVCR1	Feline leukemia virus subgroup C receptor-related protein 1 isoform X1. (470 aa)
	CITED2	Cbp/p300-interacting transactivator 2. (272 aa)
	RCOR1	REST corepressor 1. (409 aa)
	ARID4A	AT-rich interactive domain-containing protein 4A isoform X2. (1258 aa)
	TSPO2	Translocator protein 2. (171 aa)
	ATP5IF1	ATPase inhibitor, mitochondrial. (107 aa)
	KLF2	Krueppel-like factor 2. (353 aa)
	SH2B3	SH2B adapter protein 3 isoform X2. (558 aa)
	BAP1	Ubiquitin carboxyl-terminal hydrolase. (729 aa)
	KMT2E	Histone-lysine N-methyltransferase 2E isoform X1. (1854 aa)
	JMJD6	Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform X1. (402 aa)
	ETV2	ETS translocation variant 2. (362 aa)
	PLA2G10	Phospholipase A(2). (128 aa)
	DNASE2	Deoxyribonuclease 2, lysosomal. (361 aa)
	KLF1	Kruppel like factor 1. (367 aa)
	TMEM14C	Transmembrane protein 14C isoform X1. (115 aa)
	RB1	Retinoblastoma-associated protein. (922 aa)
	NCKAP1L	Nck-associated protein 1-like isoform X1. (1128 aa)
	GATA1	Erythroid transcription factor. (383 aa)
	ALAS2	5-aminolevulinate synthase. (587 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
	CUNH15orf41	Uncharacterized protein C15orf41 homolog isoform X1. (176 aa)
	HSPA9	Stress-70 protein, mitochondrial; Belongs to the heat shock protein 70 family. (679 aa)
	SLC25A38	Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis. Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. (304 aa)
	UFL1	E3 UFM1-protein ligase 1 isoform X1. (791 aa)
	LYAR	Cell growth-regulating nucleolar protein. (381 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (386 aa)
	DYRK3	Dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X1. (580 aa)
	DMTN	Dematin isoform X1. (527 aa)
	EPAS1	Endothelial PAS domain protein 1. (870 aa)
	TAL1	T-cell acute lymphocytic leukemia protein 1. (330 aa)
	JAK2	Tyrosine-protein kinase. (1132 aa)
	HCLS1	Hematopoietic lineage cell-specific protein. (484 aa)
	EPO	Erythropoietin. (192 aa)
	SLC4A1	Solute carrier family 4 member 1 (Diego blood group). (920 aa)
	BCL6	B-cell lymphoma 6 protein. (699 aa)
	SP3	Transcription factor Sp3. (781 aa)
	LYN	Tyrosine-protein kinase. (491 aa)
	CDK5RAP3	CDK5 regulatory subunit-associated protein 3 isoform X1. (505 aa)
	SMAD5	Mothers against decapentaplegic homolog. (465 aa)
	TMOD3	Tropomodulin-3 isoform X1. (309 aa)
	EPB42	Erythrocyte membrane protein band 4.2. (718 aa)
	UBA5	Ubiquitin-like modifier-activating enzyme 5 isoform X1. (404 aa)
	L3MBTL3	Lethal(3)malignant brain tumor-like protein 3 isoform X2. (779 aa)
	PKNOX1	Homeobox protein PKNOX1 isoform X1. (436 aa)
	ABCB10	ATP binding cassette subfamily B member 10. (743 aa)
	ADD1	Adducin 1. (766 aa)
	BMP4	Bone morphogenetic protein 4. (407 aa)
	TRIM10	Tripartite motif-containing protein 10. (481 aa)
	ADGRF5	Adhesion G protein-coupled receptor F5 isoform X3; Belongs to the G-protein coupled receptor 2 family. (1342 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1512 aa)
	ERCC2	TFIIH basal transcription factor complex helicase XPD subunit. (772 aa)
	JAK3	Tyrosine-protein kinase JAK3. (1125 aa)
	IKZF1	DNA-binding protein Ikaros isoform X2. (519 aa)
	MFHAS1	Malignant fibrous histiocytoma-amplified sequence 1 isoform X5. (916 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCB10	ALAS2	ENSTTRP00000009191	ENSTTRP00000004439	ATP binding cassette subfamily B member 10.	5-aminolevulinate synthase.	0.418
ABCB10	FLVCR1	ENSTTRP00000009191	ENSTTRP00000013156	ATP binding cassette subfamily B member 10.	Feline leukemia virus subgroup C receptor-related protein 1 isoform X1.	0.420
ABCB10	SLC25A38	ENSTTRP00000009191	ENSTTRP00000005293	ATP binding cassette subfamily B member 10.	Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis. Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.	0.493
ABCB10	TMEM14C	ENSTTRP00000009191	ENSTTRP00000003437	ATP binding cassette subfamily B member 10.	Transmembrane protein 14C isoform X1.	0.564
ADD1	DMTN	ENSTTRP00000008987	ENSTTRP00000011407	Adducin 1.	Dematin isoform X1.	0.777
ADD1	SLC4A1	ENSTTRP00000008987	ENSTTRP00000009969	Adducin 1.	Solute carrier family 4 member 1 (Diego blood group).	0.543
ADD1	TMOD3	ENSTTRP00000008987	ENSTTRP00000015406	Adducin 1.	Tropomodulin-3 isoform X1.	0.678
ALAS2	ABCB10	ENSTTRP00000004439	ENSTTRP00000009191	5-aminolevulinate synthase.	ATP binding cassette subfamily B member 10.	0.418
ALAS2	CUNH15orf41	ENSTTRP00000004439	ENSTTRP00000004774	5-aminolevulinate synthase.	Uncharacterized protein C15orf41 homolog isoform X1.	0.408
ALAS2	EPB42	ENSTTRP00000004439	ENSTTRP00000015130	5-aminolevulinate synthase.	Erythrocyte membrane protein band 4.2.	0.652
ALAS2	GATA1	ENSTTRP00000004439	ENSTTRP00000004388	5-aminolevulinate synthase.	Erythroid transcription factor.	0.673
ALAS2	KLF1	ENSTTRP00000004439	ENSTTRP00000003371	5-aminolevulinate synthase.	Kruppel like factor 1.	0.572
ALAS2	SLC25A38	ENSTTRP00000004439	ENSTTRP00000005293	5-aminolevulinate synthase.	Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis. Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.	0.681
ALAS2	SLC4A1	ENSTTRP00000004439	ENSTTRP00000009969	5-aminolevulinate synthase.	Solute carrier family 4 member 1 (Diego blood group).	0.687
ARID4A	KMT2E	ENSTTRP00000012837	ENSTTRP00000001387	AT-rich interactive domain-containing protein 4A isoform X2.	Histone-lysine N-methyltransferase 2E isoform X1.	0.476
ARID4A	RB1	ENSTTRP00000012837	ENSTTRP00000003992	AT-rich interactive domain-containing protein 4A isoform X2.	Retinoblastoma-associated protein.	0.916
ARID4A	RCOR1	ENSTTRP00000012837	ENSTTRP00000013115	AT-rich interactive domain-containing protein 4A isoform X2.	REST corepressor 1.	0.726
BCL6	GATA3	ENSTTRP00000016333	ENSTTRP00000004761	B-cell lymphoma 6 protein.	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	0.600
BMP4	GATA3	ENSTTRP00000008787	ENSTTRP00000004761	Bone morphogenetic protein 4.	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	0.403
BMP4	SMAD5	ENSTTRP00000008787	ENSTTRP00000015426	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.886