STRINGSTRING
BCL6 BCL6 PML PML ULK1 ULK1 ENO1 ENO1 CDK5 CDK5 SFRP1 SFRP1 SEMA3A SEMA3A SEMA3G SEMA3G SEMA4A SEMA4A SEMA6B SEMA6B SESN2 SESN2 DDX3X DDX3X PI16 PI16 SMARCA2 SMARCA2 FRZB FRZB ACVR1B ACVR1B FSTL4 FSTL4 SMAD3 SMAD3 PTPRJ PTPRJ ENSTTRP00000003143 ENSTTRP00000003143 SEMA4D SEMA4D SERTAD2 SERTAD2 INHBA INHBA WNT3 WNT3 RYK RYK DIP2B DIP2B SPART SPART SLIT3 SLIT3 RB1 RB1 SFRP2 SFRP2 RTN4 RTN4 MUL1 MUL1 SEMA6A SEMA6A CRLF3 CRLF3 DCBLD2 DCBLD2 ACVRL1 ACVRL1 SEMA5A SEMA5A BMPR2 BMPR2 BCL2 BCL2 TSPYL2 TSPYL2 SEMA3E SEMA3E WNT5A WNT5A PPP1R9B PPP1R9B SH3BP4 SH3BP4 SLIT2 SLIT2 MYL10 MYL10 FBP1 FBP1 LENG9 LENG9 ENSTTRP00000006381 ENSTTRP00000006381 IFRD2 IFRD2 HYAL1 HYAL1 HYAL2 HYAL2 SEMA6C SEMA6C FHL1 FHL1 SERTAD1 SERTAD1 SEMA3F SEMA3F SEMA3B SEMA3B GNG4 GNG4 FLCN FLCN SEMA4C SEMA4C SEMA7A SEMA7A CDKN2D CDKN2D RACK1 RACK1 RTN4R RTN4R CGRRF1 CGRRF1 GSK3A GSK3A CYP27B1 CYP27B1 OSTN OSTN CCN3 CCN3 SEMA3C SEMA3C CDKN2C CDKN2C SMARCA4 SMARCA4 SEMA3D SEMA3D PSRC1 PSRC1 CDKN2AIP CDKN2AIP NDUFA13 NDUFA13 YJEFN3 YJEFN3 ENPP1 ENPP1 ST7L ST7L DNAJB2 DNAJB2 ENSTTRP00000009560 ENSTTRP00000009560 TP53 TP53 TNR TNR PHB PHB CIRBP CIRBP PLXNA3 PLXNA3 EAF2 EAF2 SEMA5B SEMA5B SMAD4 SMAD4 MINAR1 MINAR1 MSX1 MSX1 CCAR2 CCAR2 SEMA4F SEMA4F WT1 WT1 TGFB1 TGFB1 HNF4A HNF4A OSGIN2 OSGIN2 WNT11 WNT11 RBBP7 RBBP7 SERPINE2 SERPINE2 GDF2 GDF2 CDKN1A CDKN1A MT3 MT3 BMP10 BMP10 TGFB2 TGFB2 ENSTTRP00000013099 ENSTTRP00000013099 CDHR2 CDHR2 NDUFS3 NDUFS3 CYP27C1 CYP27C1 ST7 ST7 GDF9 GDF9 DCSTAMP DCSTAMP MYL2 MYL2 STK11 STK11 CDKN1B CDKN1B SEMA4G SEMA4G RERG RERG SEMA6D SEMA6D GJA1 GJA1 EPHA7 EPHA7 SEMA4B SEMA4B ADAM15 ADAM15 SIRT1 SIRT1 KIAA0319 KIAA0319 DCUN1D3 DCUN1D3 NAIF1 NAIF1 NTN1 NTN1 HRG HRG CDKL3 CDKL3 PTPRS PTPRS CCDC85B CCDC85B OSGIN1 OSGIN1 C10orf90 C10orf90 NME6 NME6 IP6K2 IP6K2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BCL6B-cell lymphoma 6 protein. (699 aa)
PMLProtein PML isoform X2. (871 aa)
ULK1Serine/threonine-protein kinase ULK1 isoform X1. (1050 aa)
ENO1Enolase 1. (434 aa)
CDK5Cyclin dependent kinase 5. (292 aa)
SFRP1Secreted frizzled-related protein 1 isoform X2. (307 aa)
SEMA3Asemaphorin-3A; Belongs to the semaphorin family. (772 aa)
SEMA3GSemaphorin 3G. (765 aa)
SEMA4Asemaphorin-4A; Belongs to the semaphorin family. (762 aa)
SEMA6Bsemaphorin-6B-like. (677 aa)
SESN2Sestrin 2. (470 aa)
DDX3XATP-dependent RNA helicase DDX3X; Belongs to the DEAD box helicase family. (645 aa)
PI16Peptidase inhibitor 16; Belongs to the CRISP family. (462 aa)
SMARCA2Probable global transcription activator SNF2L2 isoform X1. (1573 aa)
FRZBSecreted frizzled-related protein 3. (325 aa)
ACVR1BActivin A receptor type 1B. (504 aa)
FSTL4Follistatin-related protein 4. (833 aa)
SMAD3Mothers against decapentaplegic homolog 3. (291 aa)
PTPRJPeptidylprolyl isomerase. (1262 aa)
ENSTTRP00000003143annotation not available (114 aa)
SEMA4Dsemaphorin-4D isoform X1; Belongs to the semaphorin family. (863 aa)
SERTAD2SERTA domain-containing protein 2. (263 aa)
INHBAInhibin beta A chain. (421 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
RYKTyrosine-protein kinase RYK isoform X2. (559 aa)
DIP2BDisco-interacting protein 2 homolog B isoform X2. (1574 aa)
SPARTSpartin isoform X1. (666 aa)
SLIT3Slit homolog 3 protein. (1521 aa)
RB1Retinoblastoma-associated protein. (922 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
RTN4Reticulon. (1189 aa)
MUL1Mitochondrial ubiquitin ligase activator of NFKB 1. (352 aa)
SEMA6Asemaphorin-6A isoform X1; Belongs to the semaphorin family. (1032 aa)
CRLF3Cytokine receptor-like factor 3. (441 aa)
DCBLD2Discoidin, CUB and LCCL domain-containing protein 2. (748 aa)
ACVRL1Activin A receptor like type 1. (497 aa)
SEMA5Asemaphorin-5A. (1073 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
TSPYL2Testis-specific Y-encoded-like protein 2; Belongs to the nucleosome assembly protein (NAP) family. (708 aa)
SEMA3Esemaphorin-3E; Belongs to the semaphorin family. (775 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (470 aa)
PPP1R9BNeurabin-2. (815 aa)
SH3BP4SH3 domain binding protein 4. (958 aa)
SLIT2Slit homolog 2 protein isoform X2. (1470 aa)
MYL10Myosin light chain 10. (117 aa)
FBP1Fructose-1,6-bisphosphatase 1; Belongs to the FBPase class 1 family. (276 aa)
LENG9Leukocyte receptor cluster member 9. (487 aa)
ENSTTRP00000006381annotation not available (382 aa)
IFRD2Interferon-related developmental regulator 2 isoform X2. (584 aa)
HYAL1Hyaluronidase. (432 aa)
HYAL2Hyaluronidase. (476 aa)
SEMA6CSemaphorin 6C. (966 aa)
FHL1Four and a half LIM domains protein 1 isoform X1. (323 aa)
SERTAD1SERTA domain-containing protein 1. (235 aa)
SEMA3FSemaphorin 3F. (784 aa)
SEMA3Bsemaphorin-3B; Belongs to the semaphorin family. (747 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
FLCNFolliculin isoform X2. (574 aa)
SEMA4Csemaphorin-4C. (833 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group). (663 aa)
CDKN2DCyclin-dependent kinase 4 inhibitor D. (161 aa)
RACK1Receptor of activated protein C kinase 1. (346 aa)
RTN4RReticulon-4 receptor. (481 aa)
CGRRF1Cell growth regulator with RING finger domain protein 1 isoform X1. (332 aa)
GSK3AGlycogen synthase kinase-3 alpha. (483 aa)
CYP27B125-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial isoform X2; Belongs to the cytochrome P450 family. (508 aa)
OSTNOsteocrin. (128 aa)
CCN3Protein NOV homolog. (275 aa)
SEMA3Csemaphorin-3C; Belongs to the semaphorin family. (751 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
SMARCA4Transcription activator BRG1. (1644 aa)
SEMA3Dsemaphorin-3D; Belongs to the semaphorin family. (777 aa)
PSRC1Proline/serine-rich coiled-coil protein 1. (363 aa)
CDKN2AIPCDKN2A-interacting protein isoform X1. (522 aa)
NDUFA13LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13. (227 aa)
YJEFN3YjeF N-terminal domain containing 3. (303 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (925 aa)
ST7LSuppressor of tumorigenicity 7 protein-like isoform X5. (551 aa)
DNAJB2dnaJ homolog subfamily B member 2 isoform X1. (325 aa)
ENSTTRP00000009560annotation not available (199 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
TNRtenascin-R. (1249 aa)
PHBProhibitin. (242 aa)
CIRBPCold-inducible RNA-binding protein. (172 aa)
PLXNA3plexin-A3. (1872 aa)
EAF2ELL-associated factor 2. (263 aa)
SEMA5BSemaphorin 5B. (1138 aa)
SMAD4Mothers against decapentaplegic homolog. (407 aa)
MINAR1Membrane integral NOTCH2 associated receptor 1. (916 aa)
MSX1Homeobox protein MSX-1. (303 aa)
CCAR2Cell cycle and apoptosis regulator protein 2 isoform X3. (916 aa)
SEMA4Fsemaphorin-4F isoform X1; Belongs to the semaphorin family. (773 aa)
WT1Wilms tumor protein isoform X2. (336 aa)
TGFB1Transforming growth factor beta 1. (338 aa)
HNF4AHepatocyte nuclear factor 4-alpha isoform X1. (448 aa)
OSGIN2Oxidative stress-induced growth inhibitor 2 isoform X1. (507 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (296 aa)
RBBP7Histone-binding protein RBBP7 isoform X1. (469 aa)
SERPINE2Glia-derived nexin; Belongs to the serpin family. (398 aa)
GDF2Growth/differentiation factor 2. (431 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
MT3Keratin-associated protein 5-8; Belongs to the metallothionein superfamily. Type 1 family. (67 aa)
BMP10Bone morphogenetic protein 10. (423 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (416 aa)
ENSTTRP00000013099annotation not available (288 aa)
CDHR2Cadherin-related family member 2 isoform X2. (1309 aa)
NDUFS3NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial; Belongs to the complex I 30 kDa subunit family. (266 aa)
CYP27C1Cytochrome P450 27C1 isoform X1. (372 aa)
ST7Suppressor of tumorigenicity 7 protein isoform X1. (585 aa)
GDF9Growth/differentiation factor 9 isoform X1. (454 aa)
DCSTAMPDendritic cell-specific transmembrane protein isoform X1. (470 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (166 aa)
STK11Serine/threonine-protein kinase STK11 isoform X3. (340 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (173 aa)
SEMA4Gsemaphorin-4G; Belongs to the semaphorin family. (774 aa)
RERGRas-related and estrogen-regulated growth inhibitor isoform X4. (199 aa)
SEMA6Dsemaphorin-6D; Belongs to the semaphorin family. (1073 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (381 aa)
EPHA7Ephrin type-A receptor 7 isoform X1. (998 aa)
SEMA4Bsemaphorin-4B isoform X1; Belongs to the semaphorin family. (827 aa)
ADAM15ADAM metallopeptidase domain 15. (862 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (616 aa)
KIAA0319Dyslexia-associated protein KIAA0319 homolog. (1011 aa)
DCUN1D3DCN1-like protein. (304 aa)
NAIF1Nuclear apoptosis-inducing factor 1. (327 aa)
NTN1Netrin-1. (604 aa)
HRGLOW QUALITY PROTEIN: histidine-rich glycoprotein. (481 aa)
CDKL3Cyclin-dependent kinase-like 3 isoform X2. (586 aa)
PTPRSReceptor-type tyrosine-protein phosphatase S-like. (1946 aa)
CCDC85BCoiled-coil domain-containing protein 85B. (202 aa)
OSGIN1Oxidative stress induced growth inhibitor 1. (488 aa)
C10orf90Centrosomal protein C10orf90 homolog. (697 aa)
NME6Nucleoside diphosphate kinase. (194 aa)
IP6K2Kinase; Belongs to the inositol phosphokinase (IPK) family. (448 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
Server load: low (20%) [HD]