STRINGSTRING
PIK3C3 PIK3C3 ABRAXAS2 ABRAXAS2 CEP44 CEP44 SEPTIN6 SEPTIN6 MICAL3 MICAL3 ENSTTRP00000012331 ENSTTRP00000012331 EML4 EML4 ARL3 ARL3 GEM GEM CPEB3 CPEB3 CHMP7 CHMP7 RCC2 RCC2 SIRT2 SIRT2 INCENP INCENP GDI1 GDI1 ZFYVE19 ZFYVE19 ARL8A ARL8A JTB JTB CEP126 CEP126 PTCH1 PTCH1 BIRC5 BIRC5 CHMP5 CHMP5 CHMP3 CHMP3 SH3GLB1 SH3GLB1 RACGAP1 RACGAP1 CDK1 CDK1 TTC28 TTC28 GNAI3 GNAI3 CHMP2B CHMP2B BIRC6 BIRC6 RASGEF1B RASGEF1B IST1 IST1 RAD21 RAD21 CHMP2A CHMP2A NEK2 NEK2 CTNND1 CTNND1 SSNA1 SSNA1 DCDC1 DCDC1 ENSTTRP00000002013 ENSTTRP00000002013 DCDC1-2 DCDC1-2 C6orf89 C6orf89 RALB RALB EML3 EML3 ANLN ANLN CHMP4C CHMP4C CCDC66 CCDC66 SLC2A1 SLC2A1 TTC23L TTC23L CENPF CENPF MPLKIP MPLKIP MAK MAK SPART SPART RNF8 RNF8 MICAL1 MICAL1 ANKRD54 ANKRD54 MITD1 MITD1 IQGAP1 IQGAP1 YPEL5 YPEL5 MAPRE3 MAPRE3 PRC1 PRC1 AGBL5 AGBL5 VPS4B VPS4B PLK1 PLK1 HNRNPU HNRNPU KIF20A KIF20A C9orf72 C9orf72 SEPTIN12 SEPTIN12 DCTN3 DCTN3 CDC42 CDC42 KATNAL1 KATNAL1 RAB11FIP4 RAB11FIP4 KATNA1 KATNA1 PKP4 PKP4 GNAI1 GNAI1 PIK3CB PIK3CB MYH10 MYH10 KLHDC8A KLHDC8A NEXMIF NEXMIF HEPACAM2 HEPACAM2 ENTR1 ENTR1 KLHL9 KLHL9 GNAI2 GNAI2 CENPC CENPC NAT10 NAT10 TBCK TBCK FLCN FLCN KIF4A KIF4A PKN1 PKN1 BCL3 BCL3 KEAP1 KEAP1 RACK1 RACK1 LOC101320609 LOC101320609 KIF14 KIF14 MARK4 MARK4 AGAP2 AGAP2 CEP55 CEP55 PIN1 PIN1 SLC9C2-2 SLC9C2-2 GNL3 GNL3 CDCA8 CDCA8 CHMP4A CHMP4A MDP1 MDP1 MTCL1 MTCL1 MAP11 MAP11 CRMP1 CRMP1 CAPG CAPG EXOC3 EXOC3 RAB11FIP3 RAB11FIP3 HSP90B1 HSP90B1 CLIC4 CLIC4 PSRC1 PSRC1 CENPE CENPE UVRAG UVRAG VPS4A VPS4A AURKB AURKB TXNDC9 TXNDC9 PKN2 PKN2 DTNBP1 DTNBP1 USP3 USP3 SCCPDH SCCPDH APC2 APC2 RAB8A RAB8A ARL8B ARL8B ECT2 ECT2 ALKBH4 ALKBH4 URB2 URB2 NUP62 NUP62 PPP1CC PPP1CC LZTS2 LZTS2 CYLD CYLD SEPTIN2 SEPTIN2 ZFYVE26 ZFYVE26 VPS37B VPS37B WIZ WIZ SEPTIN7 SEPTIN7 LYRM1 LYRM1 CTDP1 CTDP1 DNM2 DNM2 SVIL SVIL NUDC NUDC USP8 USP8 USP50 USP50 NUP62CL NUP62CL SEPTIN1 SEPTIN1 KLHDC8B KLHDC8B RHOA RHOA HSPA5 HSPA5 PDXP PDXP ERH ERH CHMP6 CHMP6 SPAST SPAST CCDC69 CCDC69 LOC101332449 LOC101332449
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (885 aa)
ABRAXAS2BRISC complex subunit Abro1 isoform X1. (415 aa)
CEP44Centrosomal protein of 44 kDa isoform X1. (386 aa)
SEPTIN6Septin-6 isoform X2; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (495 aa)
MICAL3Protein-methionine sulfoxide oxidase MICAL3 isoform X5. (965 aa)
ENSTTRP00000012331annotation not available (370 aa)
EML4Echinoderm microtubule-associated protein-like 4 isoform X7. (981 aa)
ARL3ADP-ribosylation factor-like protein 3; Belongs to the small GTPase superfamily. Arf family. (181 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
CPEB3Cytoplasmic polyadenylation element-binding protein 3 isoform X1. (690 aa)
CHMP7Charged multivesicular body protein 7. (453 aa)
RCC2Protein RCC2. (426 aa)
SIRT2NAD-dependent protein deacetylase sirtuin-2. (379 aa)
INCENPInner centromere protein. (870 aa)
GDI1GDP dissociation inhibitor 1. (432 aa)
ZFYVE19abscission/NoCut checkpoint regulator. (461 aa)
ARL8AADP ribosylation factor like GTPase 8A. (185 aa)
JTBProtein JTB. (146 aa)
CEP126Centrosomal protein of 126 kDa. (1085 aa)
PTCH1Protein patched homolog 1 isoform X1. (1313 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (141 aa)
CHMP5Charged multivesicular body protein 5. (196 aa)
CHMP3Charged multivesicular body protein 3 isoform X1. (221 aa)
SH3GLB1endophilin-B1. (362 aa)
RACGAP1Rac GTPase-activating protein 1-like. (632 aa)
CDK1Cyclin-dependent kinase 1 isoform X3; Belongs to the protein kinase superfamily. (301 aa)
TTC28Tetratricopeptide repeat protein 28. (2436 aa)
GNAI3G protein subunit alpha i3. (354 aa)
CHMP2BCharged multivesicular body protein 2b. (177 aa)
BIRC6LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 6. (4817 aa)
RASGEF1Bras-GEF domain-containing family member 1B isoform X3. (500 aa)
IST1IST1 homolog isoform X2. (364 aa)
RAD21Double-strand-break repair protein rad21 homolog isoform X1. (630 aa)
CHMP2ACharged multivesicular body protein 2a isoform X2. (222 aa)
NEK2Serine/threonine-protein kinase Nek2. (445 aa)
CTNND1Catenin delta-1 isoform X1. (964 aa)
SSNA1SS nuclear autoantigen 1. (119 aa)
DCDC1Doublecortin domain-containing protein 5. (672 aa)
ENSTTRP00000002013annotation not available (500 aa)
DCDC1-2Doublecortin domain-containing protein 1. (350 aa)
C6orf89Bombesin receptor-activated protein C6orf89 homolog isoform X1. (354 aa)
RALBRas-related protein Ral-B isoform X2. (202 aa)
EML3EMAP like 3. (896 aa)
ANLNAnillin isoform X3. (1117 aa)
CHMP4CCharged multivesicular body protein 4c. (237 aa)
CCDC66Coiled-coil domain-containing protein 66 isoform X4. (757 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (486 aa)
TTC23LTetratricopeptide repeat protein 23-like. (357 aa)
CENPFCentromere protein F isoform X1. (3078 aa)
MPLKIPM-phase-specific PLK1-interacting protein. (179 aa)
MAKSerine/threonine-protein kinase MAK. (623 aa)
SPARTSpartin isoform X1. (666 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (450 aa)
MICAL1Protein-methionine sulfoxide oxidase MICAL1. (1066 aa)
ANKRD54Ankyrin repeat domain-containing protein 54 isoform X1. (293 aa)
MITD1MIT domain-containing protein 1 isoform X1. (250 aa)
IQGAP1Ras GTPase-activating-like protein IQGAP1. (1658 aa)
YPEL5Protein yippee-like; Belongs to the yippee family. (121 aa)
MAPRE3Microtubule-associated protein RP/EB family member 3 isoform X1. (259 aa)
PRC1Protein regulator of cytokinesis 1 isoform X1. (616 aa)
AGBL5Cytosolic carboxypeptidase-like protein 5 isoform X2. (885 aa)
VPS4BVacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family. (443 aa)
PLK1Serine/threonine-protein kinase PLK. (602 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U isoform X1. (818 aa)
KIF20AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (890 aa)
C9orf72Protein C9orf72 homolog. (481 aa)
SEPTIN12Septin-12; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (376 aa)
DCTN3Dynactin subunit 3. (186 aa)
CDC42Cell division control protein 42 homolog. (156 aa)
KATNAL1Katanin p60 ATPase-containing subunit A-like 1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neur [...] (489 aa)
RAB11FIP4Rab11 family-interacting protein 4. (555 aa)
KATNA1Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal p [...] (491 aa)
PKP4Plakophilin-4 isoform X1. (1192 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
MYH10Myosin-10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2004 aa)
KLHDC8AKelch domain-containing protein 8A. (350 aa)
NEXMIFProtein KIAA2022 homolog. (1514 aa)
HEPACAM2HEPACAM family member 2 isoform X1. (461 aa)
ENTR1Serologically defined colon cancer antigen 3. (430 aa)
KLHL9Kelch-like protein 9. (617 aa)
GNAI2G protein subunit alpha i2. (351 aa)
CENPCCentromere protein C isoform X1. (928 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1024 aa)
TBCKTBC domain-containing protein kinase-like protein isoform X1. (893 aa)
FLCNFolliculin isoform X2. (574 aa)
KIF4AChromosome-associated kinesin KIF4A isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1233 aa)
PKN1Protein kinase N1. (789 aa)
BCL3B-cell lymphoma 3 protein. (451 aa)
KEAP1Kelch-like ECH-associated protein 1. (623 aa)
RACK1Receptor of activated protein C kinase 1. (346 aa)
LOC101320609Charged multivesicular body protein 1b-2-like isoform X5. (199 aa)
KIF14Kinesin-like protein KIF14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1509 aa)
MARK4MAP/microtubule affinity-regulating kinase 4 isoform X1. (735 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1190 aa)
CEP55Centrosomal protein of 55 kDa isoform X1. (463 aa)
PIN1LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase NIMA-interacting 1. (162 aa)
SLC9C2-2Sodium/hydrogen exchanger 11 isoform X1. (283 aa)
GNL3Guanine nucleotide-binding protein-like 3 isoform X2. (341 aa)
CDCA8Borealin. (204 aa)
CHMP4ACharged multivesicular body protein 4a isoform X1. (244 aa)
MDP1Magnesium-dependent phosphatase 1. (173 aa)
MTCL1Microtubule cross-linking factor 1 isoform X2. (1643 aa)
MAP11Microtubule associated protein 11. (579 aa)
CRMP1Dihydropyrimidinase-related protein 1 isoform X1. (685 aa)
CAPGCapping actin protein, gelsolin like. (349 aa)
EXOC3Exocyst complex component 3. (688 aa)
RAB11FIP3Rab11 family-interacting protein 3. (691 aa)
HSP90B1Endoplasmin. (803 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
PSRC1Proline/serine-rich coiled-coil protein 1. (363 aa)
CENPECentromere-associated protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2705 aa)
UVRAGUV radiation resistance-associated gene protein isoform X1. (699 aa)
VPS4AVacuolar protein sorting-associated protein 4A isoform X1; Belongs to the AAA ATPase family. (433 aa)
AURKBAurora kinase B isoform X4; Belongs to the protein kinase superfamily. (250 aa)
TXNDC9Thioredoxin domain-containing protein 9. (226 aa)
PKN2Serine/threonine-protein kinase N2 isoform X1. (917 aa)
DTNBP1Dysbindin. (330 aa)
USP3Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (489 aa)
SCCPDHSaccharopine dehydrogenase-like oxidoreductase isoform X2. (424 aa)
APC2Adenomatous polyposis coli protein 2-like. (2262 aa)
RAB8ARas-related protein Rab-8A. (207 aa)
ARL8BLOW QUALITY PROTEIN: ADP-ribosylation factor-like protein 8B; Belongs to the small GTPase superfamily. Arf family. (186 aa)
ECT2Protein ECT2 isoform X5. (914 aa)
ALKBH4Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4. (298 aa)
URB2Unhealthy ribosome biogenesis protein 2 homolog isoform X5. (1513 aa)
NUP62Nuclear pore glycoprotein p62. (516 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (293 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (668 aa)
CYLDUbiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family. (956 aa)
SEPTIN2Septin-2; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (372 aa)
ZFYVE26Zinc finger FYVE domain-containing protein 26 isoform X4. (2476 aa)
VPS37BVPS37B subunit of ESCRT-I. (286 aa)
WIZProtein Wiz. (1565 aa)
SEPTIN7Septin-7 isoform X6; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (415 aa)
LYRM1LYR motif-containing protein 1; Belongs to the complex I LYR family. (122 aa)
CTDP1RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (916 aa)
DNM2Dynamin-2 isoform X4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (871 aa)
SVILSupervillin isoform X8. (2175 aa)
NUDCNuclear migration protein nudC isoform X2. (332 aa)
USP8Ubiquitin carboxyl-terminal hydrolase 8; Belongs to the peptidase C19 family. (1117 aa)
USP50Inactive ubiquitin carboxyl-terminal hydrolase 50; Belongs to the peptidase C19 family. (337 aa)
NUP62CLNucleoporin-62 C-terminal-like protein. (267 aa)
SEPTIN1Septin 1. (367 aa)
KLHDC8BKelch domain containing 8B. (354 aa)
RHOATransforming protein RhoA. (193 aa)
HSPA578 kDa glucose-regulated protein; Belongs to the heat shock protein 70 family. (654 aa)
PDXPPyridoxal phosphate phosphatase; Belongs to the HAD-like hydrolase superfamily. (216 aa)
ERHEnhancer of rudimentary homolog; May have a role in the cell cycle. (104 aa)
CHMP6Charged multivesicular body protein 6. (202 aa)
SPASTSpastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (609 aa)
CCDC69Coiled-coil domain-containing protein 69. (296 aa)
LOC101332449Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (318 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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