STRINGSTRING
HIVEP1 HIVEP1 GDF5 GDF5 HJV HJV SMURF1 SMURF1 SMAD3 SMAD3 NODAL NODAL BMPER BMPER ZCCHC18 ZCCHC18 NOTCH2 NOTCH2 ATF2 ATF2 RGMA RGMA GDF3 GDF3 ENSTTRP00000000710 ENSTTRP00000000710 SFRP1 SFRP1 TMPRSS6 TMPRSS6 HES1 HES1 ETV2 ETV2 BMP2 BMP2 SMAD2 SMAD2 SPART SPART FAM83G FAM83G GDF15 GDF15 SMAD7 SMAD7 SFRP2 SFRP2 ACVRL1 ACVRL1 BMPR2 BMPR2 WNT5A WNT5A EGR1 EGR1 MAPK3 MAPK3 BMP5 BMP5 SCX SCX RUNX2 RUNX2 PDCD4 PDCD4 SLC39A5 SLC39A5 DLX5 DLX5 ACVR1 ACVR1 SMAD9 SMAD9 SMAD1 SMAD1 LEF1 LEF1 BMPR1A BMPR1A DDX5 DDX5 BMP4 BMP4 ZNF831 ZNF831 SOSTDC1 SOSTDC1 SMAD6 SMAD6 COMP COMP CHRD CHRD USP15 USP15 LOC101325454 LOC101325454 GDF1 GDF1 TMEM100 TMEM100 SMAD4 SMAD4 MSX1 MSX1 FST FST GDF6 GDF6 ENSTTRP00000011729 ENSTTRP00000011729 CCDC142 CCDC142 CHRDL1 CHRDL1 GDF2 GDF2 BMP10 BMP10 TGFB2 TGFB2 RGMB RGMB USP9X USP9X MEGF8 MEGF8 TGFBR3 TGFBR3 LOC101327238 LOC101327238 EXT1 EXT1 TWSG1 TWSG1 SLC33A1 SLC33A1 BMPR1B BMPR1B ABL1 ABL1 TGFB3 TGFB3 BMP7 BMP7 ZNF8 ZNF8 BMP6 BMP6 SMAD5 SMAD5 ACVR2A ACVR2A HFE HFE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HIVEP1Zinc finger protein 40 isoform X2. (2703 aa)
GDF5Growth/differentiation factor 5. (489 aa)
HJVHemojuvelin isoform X1. (426 aa)
SMURF1E3 ubiquitin-protein ligase. (738 aa)
SMAD3Mothers against decapentaplegic homolog 3. (291 aa)
NODALNodal homolog. (348 aa)
BMPERBMP-binding endothelial regulator protein. (640 aa)
ZCCHC18Zinc finger CCHC domain-containing protein 18. (403 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform X1. (2471 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
RGMARepulsive guidance molecule A isoform X1. (450 aa)
GDF3Growth/differentiation factor 3. (364 aa)
ENSTTRP00000000710annotation not available (306 aa)
SFRP1Secreted frizzled-related protein 1 isoform X2. (307 aa)
TMPRSS6Transmembrane serine protease 6. (821 aa)
HES1Transcription factor HES-1. (280 aa)
ETV2ETS translocation variant 2. (362 aa)
BMP2Bone morphogenetic protein 2. (388 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
SPARTSpartin isoform X1. (666 aa)
FAM83GProtein FAM83G-like. (808 aa)
GDF15Growth differentiation factor 15. (308 aa)
SMAD7Mothers against decapentaplegic homolog 7 isoform X1. (426 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
ACVRL1Activin A receptor like type 1. (497 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (470 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (509 aa)
MAPK3Mitogen-activated protein kinase 3. (382 aa)
BMP5Bone morphogenetic protein 5 isoform X2. (454 aa)
SCXScleraxis bHLH transcription factor. (203 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (587 aa)
PDCD4Programmed cell death protein 4 isoform X1. (469 aa)
SLC39A5Solute carrier family 39 member 5. (540 aa)
DLX5Homeobox protein DLX-5. (289 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (485 aa)
SMAD9Mothers against decapentaplegic homolog. (466 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
LEF1Lymphoid enhancer binding factor 1. (396 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
DDX5Probable ATP-dependent RNA helicase DDX5. (614 aa)
BMP4Bone morphogenetic protein 4. (407 aa)
ZNF831Zinc finger protein 831-like. (1615 aa)
SOSTDC1Sclerostin domain-containing protein 1. (229 aa)
SMAD6SMAD family member 6. (492 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
CHRDChordin. (908 aa)
USP15Ubiquitin specific peptidase 15. (981 aa)
LOC101325454Bone morphogenetic protein 8B. (241 aa)
GDF1Embryonic growth/differentiation factor 1. (370 aa)
TMEM100Transmembrane protein 100. (134 aa)
SMAD4Mothers against decapentaplegic homolog. (407 aa)
MSX1Homeobox protein MSX-1. (303 aa)
FSTFollistatin isoform X2. (343 aa)
GDF6Growth/differentiation factor 6. (458 aa)
ENSTTRP00000011729annotation not available (367 aa)
CCDC142Coiled-coil domain-containing protein 142 isoform X1. (749 aa)
CHRDL1Chordin-like protein 1 isoform X3. (457 aa)
GDF2Growth/differentiation factor 2. (431 aa)
BMP10Bone morphogenetic protein 10. (423 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (416 aa)
RGMBRGM domain family member B. (587 aa)
USP9XProbable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X2; Belongs to the peptidase C19 family. (2527 aa)
MEGF8Multiple epidermal growth factor-like domains protein 8. (2767 aa)
TGFBR3Transforming growth factor beta receptor type 3 isoform X4. (848 aa)
LOC101327238Left-right determination factor. (201 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (746 aa)
TWSG1Twisted gastrulation protein homolog 1. (223 aa)
SLC33A1Acetyl-coenzyme A transporter 1. (550 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (411 aa)
BMP7Bone morphogenetic protein 7 isoform X2. (431 aa)
ZNF8Zinc finger protein 8 isoform X1. (559 aa)
BMP6Bone morphogenetic protein 6. (304 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
HFEHereditary hemochromatosis protein; Belongs to the MHC class I family. (348 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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