(81 nodes) Regulation of BMP signaling pathway network (Tursiops truncatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ABL1	Tyrosine-protein kinase. (1148 aa)
	CTDSPL2	CTD small phosphatase-like protein 2 isoform X1. (461 aa)
	FBN1	Fibrillin-1. (2826 aa)
	NEO1	Neogenin isoform X4. (1450 aa)
	UBE2O	(E3-independent) E2 ubiquitin-conjugating enzyme. (1293 aa)
	PPM1A	Protein phosphatase 1A. (382 aa)
	SMURF2	E3 ubiquitin-protein ligase. (648 aa)
	ENSTTRP00000007925	annotation not available (380 aa)
	FSTL1	Follistatin-related protein 1. (306 aa)
	VWC2L	Von Willebrand factor C domain-containing protein 2-like. (137 aa)
	DLX6	Homeobox protein DLX-6. (232 aa)
	NOTCH1	Neurogenic locus notch homolog protein 1. (2527 aa)
	LEMD2	LEM domain-containing protein 2 isoform X1. (503 aa)
	LRP2	Low-density lipoprotein receptor-related protein 2. (4599 aa)
	GPC3	Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (597 aa)
	CHRDL2	Chordin like 2. (452 aa)
	ITGA3	Integrin subunit alpha 3. (1068 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (470 aa)
	HTRA1	Serine protease HTRA1. (322 aa)
	CRIM1	Cysteine-rich motor neuron 1 protein isoform X1. (1025 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
	ACVRL1	Activin A receptor like type 1. (497 aa)
	SKOR2	SKI family transcriptional corepressor 2. (296 aa)
	ENG	Endoglin. (655 aa)
	CER1	Cerberus. (271 aa)
	GDF5	Growth/differentiation factor 5. (489 aa)
	HJV	Hemojuvelin isoform X1. (426 aa)
	VWC2	Brorin isoform X1. (199 aa)
	TBX20	T-box transcription factor TBX20. (449 aa)
	SCUBE3	Signal peptide, CUB and EGF-like domain-containing protein 1. (1007 aa)
	ENSTTRP00000009296	annotation not available (181 aa)
	SOSTDC1	Sclerostin domain-containing protein 1. (229 aa)
	SKI	Ski oncogene. (633 aa)
	SFRP5	Secreted frizzled-related protein 5. (252 aa)
	SMAD6	SMAD family member 6. (492 aa)
	CDH5	Cadherin-5. (779 aa)
	CHRD	Chordin. (908 aa)
	SULF1	Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
	FSTL3	Follistatin like 3. (262 aa)
	DLX1	Distal-less homeobox 1. (255 aa)
	CRB2	Crumbs cell polarity complex component 2. (1254 aa)
	SMAD4	Mothers against decapentaplegic homolog. (407 aa)
	MSX1	Homeobox protein MSX-1. (303 aa)
	LEMD3	Inner nuclear membrane protein Man1 isoform X1. (904 aa)
	CHRDL1	Chordin-like protein 1 isoform X3. (457 aa)
	GDF2	Growth/differentiation factor 2. (431 aa)
	KIAA1324L	UPF0577 protein KIAA1324-like homolog. (802 aa)
	ENSTTRP00000012809	annotation not available (161 aa)
	RNF165	RING finger protein 165. (308 aa)
	LOC101331122	Kielin/chordin-like protein. (254 aa)
	ZNF423	Zinc finger protein 423. (1278 aa)
	NOTCH2	Neurogenic locus notch homolog protein 2 isoform X1. (2471 aa)
	ENSTTRP00000000710	annotation not available (306 aa)
	BMP4	Bone morphogenetic protein 4. (407 aa)
	SFRP1	Secreted frizzled-related protein 1 isoform X2. (307 aa)
	TMPRSS6	Transmembrane serine protease 6. (821 aa)
	CYR61	Protein CYR61. (382 aa)
	TNFAIP6	Tumor necrosis factor-inducible gene 6 protein isoform X2. (277 aa)
	HES1	Transcription factor HES-1. (280 aa)
	PELO	Protein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
	SKIL	Ski-like protein isoform X1. (681 aa)
	KDR	Vascular endothelial growth factor receptor 2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1307 aa)
	TRIM33	E3 ubiquitin-protein ligase TRIM33 isoform X3. (1127 aa)
	TOB1	Protein Tob1. (344 aa)
	ENSTTRP00000013860	annotation not available (807 aa)
	TWSG1	Twisted gastrulation protein homolog 1. (223 aa)
	SORL1	Sortilin-related receptor. (2205 aa)
	SMURF1	E3 ubiquitin-protein ligase. (738 aa)
	SKOR1	SKI family transcriptional corepressor 1. (960 aa)
	BAMBI	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (234 aa)
	BMPER	BMP-binding endothelial regulator protein. (640 aa)
	TFAP2B	Transcription factor AP-2-beta isoform X4. (360 aa)
	SPART	Spartin isoform X1. (666 aa)
	HTRA3	HtrA serine peptidase 3. (453 aa)
	NUMA1	Nuclear mitotic apparatus protein 1 isoform X1. (2113 aa)
	SMAD7	Mothers against decapentaplegic homolog 7 isoform X1. (426 aa)
	NBL1	Neuroblastoma suppressor of tumorigenicity 1 isoform X2. (211 aa)
	SFRP2	Secreted frizzled-related protein 2. (294 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	ILK	Integrin-linked protein kinase. (450 aa)
	HIPK2	Homeodomain-interacting protein kinase 2. (1185 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	NOTCH1	ENSTTRP00000014381	ENSTTRP00000007173	Tyrosine-protein kinase.	Neurogenic locus notch homolog protein 1.	0.425
ABL1	SMURF1	ENSTTRP00000014381	ENSTTRP00000002810	Tyrosine-protein kinase.	E3 ubiquitin-protein ligase.	0.413
ABL1	SMURF2	ENSTTRP00000014381	ENSTTRP00000008398	Tyrosine-protein kinase.	E3 ubiquitin-protein ligase.	0.413
ACVRL1	BAMBI	ENSTTRP00000004656	ENSTTRP00000002880	Activin A receptor like type 1.	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	0.648
ACVRL1	BMP4	ENSTTRP00000004656	ENSTTRP00000008787	Activin A receptor like type 1.	Bone morphogenetic protein 4.	0.937
ACVRL1	BMPR2	ENSTTRP00000004656	ENSTTRP00000004697	Activin A receptor like type 1.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.974
ACVRL1	ENG	ENSTTRP00000004656	ENSTTRP00000015608	Activin A receptor like type 1.	Endoglin.	0.771
ACVRL1	GDF2	ENSTTRP00000004656	ENSTTRP00000012735	Activin A receptor like type 1.	Growth/differentiation factor 2.	0.995
ACVRL1	GDF5	ENSTTRP00000004656	ENSTTRP00000016136	Activin A receptor like type 1.	Growth/differentiation factor 5.	0.632
ACVRL1	HJV	ENSTTRP00000004656	ENSTTRP00000016221	Activin A receptor like type 1.	Hemojuvelin isoform X1.	0.648
ACVRL1	NEO1	ENSTTRP00000004656	ENSTTRP00000014851	Activin A receptor like type 1.	Neogenin isoform X4.	0.602
ACVRL1	SMAD4	ENSTTRP00000004656	ENSTTRP00000011160	Activin A receptor like type 1.	Mothers against decapentaplegic homolog.	0.727
ACVRL1	SMAD6	ENSTTRP00000004656	ENSTTRP00000009705	Activin A receptor like type 1.	SMAD family member 6.	0.705
ACVRL1	SMAD7	ENSTTRP00000004656	ENSTTRP00000004100	Activin A receptor like type 1.	Mothers against decapentaplegic homolog 7 isoform X1.	0.798
ACVRL1	SMURF1	ENSTTRP00000004656	ENSTTRP00000002810	Activin A receptor like type 1.	E3 ubiquitin-protein ligase.	0.592
ACVRL1	SMURF2	ENSTTRP00000004656	ENSTTRP00000008398	Activin A receptor like type 1.	E3 ubiquitin-protein ligase.	0.592
BAMBI	ACVRL1	ENSTTRP00000002880	ENSTTRP00000004656	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Activin A receptor like type 1.	0.648
BAMBI	BMP4	ENSTTRP00000002880	ENSTTRP00000008787	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Bone morphogenetic protein 4.	0.556
BAMBI	BMPR2	ENSTTRP00000002880	ENSTTRP00000004697	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.547
BAMBI	LRP2	ENSTTRP00000002880	ENSTTRP00000006193	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Low-density lipoprotein receptor-related protein 2.	0.404