(34 nodes) Negative regulation of epithelial cell differentiation network (Tursiops truncatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (134 aa)
	NOTCH1	Neurogenic locus notch homolog protein 1. (2527 aa)
	VHL	LOW QUALITY PROTEIN: von Hippel-Lindau disease tumor suppressor. (206 aa)
	HOXA7	Homeobox protein Hox-A7. (235 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	GRHL2	Grainyhead-like protein 2 homolog isoform X4. (619 aa)
	SOX9	Transcription factor SOX-9. (509 aa)
	ACVRL1	Activin A receptor like type 1. (497 aa)
	NKX6-3	NK6 homeobox 3. (116 aa)
	TBX3	T-box transcription factor TBX3. (742 aa)
	NODAL	Nodal homolog. (348 aa)
	FRZB	Secreted frizzled-related protein 3. (325 aa)
	HES1	Transcription factor HES-1. (280 aa)
	SIX2	Homeobox protein SIX2. (168 aa)
	XDH	Xanthine dehydrogenase/oxidase. (1332 aa)
	EZH2	Histone-lysine N-methyltransferase EZH2 isoform X2. (751 aa)
	CCND1	G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
	SRSF6	LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 6-like. (259 aa)
	SPRY1	Protein sprouty homolog 1. (319 aa)
	FOXJ2	Forkhead box protein J2. (566 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (784 aa)
	SPRED1	Sprouty-related, EVH1 domain-containing protein 1. (436 aa)
	KRAS	GTPase KRas. (189 aa)
	FST	Follistatin isoform X2. (343 aa)
	MMP9	Matrix metalloproteinase-9. (670 aa)
	ZEB1	Zinc finger E-box-binding homeobox 1 isoform X1. (1120 aa)
	YAP1	Transcriptional coactivator YAP1 isoform X4. (488 aa)
	SPRY2	Protein sprouty homolog 2. (315 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	FGF10	Fibroblast growth factor 10. (142 aa)
	OSR1	Protein odd-skipped-related 1. (267 aa)
	ENSTTRP00000009296	annotation not available (181 aa)
	SMO	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVRL1	NODAL	ENSTTRP00000004656	ENSTTRP00000002983	Activin A receptor like type 1.	Nodal homolog.	0.525
ACVRL1	SPRY2	ENSTTRP00000004656	ENSTTRP00000011048	Activin A receptor like type 1.	Protein sprouty homolog 2.	0.426
ACVRL1	YAP1	ENSTTRP00000004656	ENSTTRP00000011064	Activin A receptor like type 1.	Transcriptional coactivator YAP1 isoform X4.	0.418
CAV1	CCND1	ENSTTRP00000008073	ENSTTRP00000016405	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.422
CAV1	CTNNB1	ENSTTRP00000008073	ENSTTRP00000005764	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Catenin beta-1.	0.797
CAV1	MMP9	ENSTTRP00000008073	ENSTTRP00000011485	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Matrix metalloproteinase-9.	0.471
CAV1	SPRED1	ENSTTRP00000008073	ENSTTRP00000012547	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Sprouty-related, EVH1 domain-containing protein 1.	0.405
CCND1	CAV1	ENSTTRP00000016405	ENSTTRP00000008073	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.422
CCND1	CTNNB1	ENSTTRP00000016405	ENSTTRP00000005764	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Catenin beta-1.	0.819
CCND1	EZH2	ENSTTRP00000016405	ENSTTRP00000016466	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Histone-lysine N-methyltransferase EZH2 isoform X2.	0.529
CCND1	FGF10	ENSTTRP00000016405	ENSTTRP00000009805	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Fibroblast growth factor 10.	0.404
CCND1	JAG1	ENSTTRP00000016405	ENSTTRP00000005880	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.672
CCND1	KRAS	ENSTTRP00000016405	ENSTTRP00000011954	G1/S-specific cyclin-D1; Belongs to the cyclin family.	GTPase KRas.	0.628
CCND1	MMP9	ENSTTRP00000016405	ENSTTRP00000011485	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Matrix metalloproteinase-9.	0.738
CCND1	NOTCH1	ENSTTRP00000016405	ENSTTRP00000007173	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Neurogenic locus notch homolog protein 1.	0.703
CCND1	SMO	ENSTTRP00000016405	ENSTTRP00000008000	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family.	0.431
CCND1	SOX9	ENSTTRP00000016405	ENSTTRP00000005370	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Transcription factor SOX-9.	0.502
CCND1	YAP1	ENSTTRP00000016405	ENSTTRP00000011064	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Transcriptional coactivator YAP1 isoform X4.	0.488
CCND1	ZEB1	ENSTTRP00000016405	ENSTTRP00000011188	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Zinc finger E-box-binding homeobox 1 isoform X1.	0.551
CTNNB1	CAV1	ENSTTRP00000005764	ENSTTRP00000008073	Catenin beta-1.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.797