STRINGSTRING
STAT6 STAT6 CSN2 CSN2 TNFRSF11A TNFRSF11A NOTCH4 NOTCH4 TPH1 TPH1 CSN3 CSN3 ORAI1 ORAI1 CCL11 CCL11 BTRC BTRC CREB1 CREB1 ENSTTRP00000015206 ENSTTRP00000015206 ZBTB7B ZBTB7B PYGO2 PYGO2 PRL PRL RXFP1 RXFP1 LRP5 LRP5 NTN1 NTN1 MAPK1 MAPK1 ZNF703 ZNF703 SCRIB SCRIB EPHA2 EPHA2 CCND1 CCND1 PML PML GHRHR GHRHR LRRC1 LRRC1 KDM5B KDM5B IQGAP3 IQGAP3 IRF6 IRF6 CSMD2 CSMD2 MST1 MST1 ESR1 ESR1 NRG3 NRG3 TBX3 TBX3 SOCS2 SOCS2 ENSTTRP00000003132 ENSTTRP00000003132 NEURL1 NEURL1 GPAT4 GPAT4 SLC6A3 SLC6A3 GLI3 GLI3 WNT3 WNT3 CEBPB CEBPB AR AR TBX2 TBX2 EGF EGF PHB2 PHB2 WNT5A WNT5A SOX9 SOX9 SRC SRC FOXF1 FOXF1 ELF3 ELF3 LATS1 LATS1 BCL2L11 BCL2L11 STAT5B STAT5B ENSTTRP00000006381 ENSTTRP00000006381 HOXA5 HOXA5 TGFA TGFA STAT5A STAT5A LEF1 LEF1 ENSTTRP00000007731 ENSTTRP00000007731 AGAP2 AGAP2 SMO SMO MED1 MED1 CAV1 CAV1 ID2 ID2 BMP4 BMP4 FASN FASN SOSTDC1 SOSTDC1 ERBB4 ERBB4 TNFSF11 TNFSF11 WNT2 WNT2 FGF10 FGF10 NFKB1 NFKB1 PTCH1 PTCH1 BSX BSX ARHGAP35 ARHGAP35 AREG AREG MSX1 MSX1 DDR1 DDR1 HOXB9 HOXB9 ATP2C2 ATP2C2 HIF1A HIF1A VDR VDR TGFB1 TGFB1 CSMD1 CSMD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STAT6Signal transducer and activator of transcription 6. (847 aa)
CSN2Beta-casein. (216 aa)
TNFRSF11ATumor necrosis factor receptor superfamily member 11A isoform X2. (562 aa)
NOTCH4Neurogenic locus notch homolog protein 4. (1982 aa)
TPH1Tryptophan 5-hydroxylase 1. (465 aa)
CSN3Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk; Belongs to the kappa-casein family. (181 aa)
ORAI1Calcium release-activated calcium channel protein 1. (238 aa)
CCL11C-C motif chemokine. (97 aa)
BTRCF-box/WD repeat-containing protein 1A isoform X1. (605 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
ENSTTRP00000015206annotation not available (554 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (416 aa)
PYGO2Pygopus family PHD finger 2. (406 aa)
PRLProlactin isoform X1. (230 aa)
RXFP1Relaxin receptor 1. (757 aa)
LRP5LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 5. (1582 aa)
NTN1Netrin-1. (604 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (320 aa)
ZNF703Zinc finger protein 703. (585 aa)
SCRIBProtein scribble homolog. (1596 aa)
EPHA2Ephrin type-A receptor 2-like. (974 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
PMLProtein PML isoform X2. (871 aa)
GHRHRGrowth hormone-releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (420 aa)
LRRC1Leucine-rich repeat-containing protein 1 isoform X1. (522 aa)
KDM5BLysine-specific demethylase 5B isoform X1. (1631 aa)
IQGAP3Ras GTPase-activating-like protein IQGAP3 isoform X1. (1636 aa)
IRF6Interferon regulatory factor 6 isoform X2. (467 aa)
CSMD2LOW QUALITY PROTEIN: CUB and sushi domain-containing protein 2-like. (3632 aa)
MST1Hepatocyte growth factor-like protein isoform X1; Belongs to the peptidase S1 family. Plasminogen subfamily. (709 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
NRG3Pro-neuregulin-3, membrane-bound isoform. (724 aa)
TBX3T-box transcription factor TBX3. (742 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
ENSTTRP00000003132annotation not available (134 aa)
NEURL1E3 ubiquitin-protein ligase NEURL1. (574 aa)
GPAT4Glycerol-3-phosphate acyltransferase 4 isoform X1. (454 aa)
SLC6A3Solute carrier family 6 member 3. (617 aa)
GLI3Transcriptional activator GLI3. (1580 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
ARAndrogen receptor. (886 aa)
TBX2T-box transcription factor TBX2. (703 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1205 aa)
PHB2Prohibitin 2. (298 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (470 aa)
SOX9Transcription factor SOX-9. (509 aa)
SRCProto-oncogene tyrosine-protein kinase Src. (538 aa)
FOXF1Forkhead box F1. (372 aa)
ELF3ETS-related transcription factor Elf-3. (340 aa)
LATS1Serine/threonine-protein kinase LATS1. (958 aa)
BCL2L11Bcl-2-like protein 11 isoform X1. (196 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
ENSTTRP00000006381annotation not available (382 aa)
HOXA5Homeobox A5. (268 aa)
TGFAProtransforming growth factor alpha isoform X1. (224 aa)
STAT5ASignal transducer and activator of transcription 5A. (794 aa)
LEF1Lymphoid enhancer binding factor 1. (396 aa)
ENSTTRP00000007731annotation not available (287 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1190 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1512 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (134 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
BMP4Bone morphogenetic protein 4. (407 aa)
FASNFatty acid synthase. (2087 aa)
SOSTDC1Sclerostin domain-containing protein 1. (229 aa)
ERBB4Receptor protein-tyrosine kinase. (1299 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (318 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
FGF10Fibroblast growth factor 10. (142 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (964 aa)
PTCH1Protein patched homolog 1 isoform X1. (1313 aa)
BSXBrain-specific homeobox protein homolog. (197 aa)
ARHGAP35Rho GTPase-activating protein 35 isoform X1. (1510 aa)
AREGAmphiregulin isoform X2. (253 aa)
MSX1Homeobox protein MSX-1. (303 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (915 aa)
HOXB9Homeobox protein Hox-B9. (250 aa)
ATP2C2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (937 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (824 aa)
VDRVitamin D3 receptor. (427 aa)
TGFB1Transforming growth factor beta 1. (338 aa)
CSMD1CUB and sushi domain-containing protein 1. (3040 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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