(30 nodes) Midbrain development network (Tursiops truncatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSTTRP00000007731	annotation not available (287 aa)
	EN1	Homeobox protein engrailed-like. (400 aa)
	HES1	Transcription factor HES-1. (280 aa)
	TAL2	T-cell acute lymphocytic leukemia protein 2. (105 aa)
	LMX1A	LIM homeobox transcription factor 1-alpha. (382 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	WNT9B	Wnt family member 9B. (330 aa)
	RYK	Tyrosine-protein kinase RYK isoform X2. (559 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (470 aa)
	OTX1	Homeobox protein OTX1. (355 aa)
	FZD3	Frizzled-3 isoform X2; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	KAT2A	Histone acetyltransferase KAT2A. (835 aa)
	ENSTTRP00000006381	annotation not available (382 aa)
	TFAP2D	Transcription factor AP-2-delta. (452 aa)
	DLG5	Disks large homolog 5; Belongs to the MAGUK family. (1816 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	PITX3	Homeobox protein. (289 aa)
	UCHL5	Ubiquitin carboxyl-terminal hydrolase. (331 aa)
	PHOX2A	Paired like homeobox 2A. (285 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	MSX1	Homeobox protein MSX-1. (303 aa)
	NDST1	Sulfotransferase; Belongs to the sulfotransferase 1 family. (882 aa)
	EN2	Homeobox protein engrailed-2. (324 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (449 aa)
	BARHL1	barH-like 1 homeobox protein. (324 aa)
	KDM2B	LOW QUALITY PROTEIN: lysine-specific demethylase 2B. (1332 aa)
	SOS1	Son of sevenless homolog 1 isoform X1. (1304 aa)
	FZD6	Frizzled-6 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (707 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTNNB1	DLG5	ENSTTRP00000005764	ENSTTRP00000007372	Catenin beta-1.	Disks large homolog 5; Belongs to the MAGUK family.	0.505
CTNNB1	ENSTTRP00000006381	ENSTTRP00000005764	ENSTTRP00000006381	Catenin beta-1.	annotation not available	0.901
CTNNB1	ENSTTRP00000007731	ENSTTRP00000005764	ENSTTRP00000007731	Catenin beta-1.	annotation not available	0.645
CTNNB1	FZD3	ENSTTRP00000005764	ENSTTRP00000005592	Catenin beta-1.	Frizzled-3 isoform X2; Belongs to the G-protein coupled receptor Fz/Smo family.	0.770
CTNNB1	FZD6	ENSTTRP00000005764	ENSTTRP00000014959	Catenin beta-1.	Frizzled-6 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.670
CTNNB1	RYK	ENSTTRP00000005764	ENSTTRP00000003534	Catenin beta-1.	Tyrosine-protein kinase RYK isoform X2.	0.560
CTNNB1	SHH	ENSTTRP00000005764	ENSTTRP00000013015	Catenin beta-1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.683
CTNNB1	SMAD1	ENSTTRP00000005764	ENSTTRP00000007646	Catenin beta-1.	Mothers against decapentaplegic homolog.	0.476
CTNNB1	WNT1	ENSTTRP00000005764	ENSTTRP00000004432	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.900
CTNNB1	WNT2	ENSTTRP00000005764	ENSTTRP00000009799	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.752
CTNNB1	WNT3	ENSTTRP00000005764	ENSTTRP00000003467	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.850
CTNNB1	WNT5A	ENSTTRP00000005764	ENSTTRP00000004970	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.819
CTNNB1	WNT9B	ENSTTRP00000005764	ENSTTRP00000003470	Catenin beta-1.	Wnt family member 9B.	0.633
DLG5	CTNNB1	ENSTTRP00000007372	ENSTTRP00000005764	Disks large homolog 5; Belongs to the MAGUK family.	Catenin beta-1.	0.505
EN1	EN2	ENSTTRP00000001033	ENSTTRP00000012998	Homeobox protein engrailed-like.	Homeobox protein engrailed-2.	0.560
EN1	LMX1A	ENSTTRP00000001033	ENSTTRP00000003419	Homeobox protein engrailed-like.	LIM homeobox transcription factor 1-alpha.	0.443
EN1	SHH	ENSTTRP00000001033	ENSTTRP00000013015	Homeobox protein engrailed-like.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.596
EN1	WNT1	ENSTTRP00000001033	ENSTTRP00000004432	Homeobox protein engrailed-like.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.681
EN2	EN1	ENSTTRP00000012998	ENSTTRP00000001033	Homeobox protein engrailed-2.	Homeobox protein engrailed-like.	0.560
EN2	WNT2	ENSTTRP00000012998	ENSTTRP00000009799	Homeobox protein engrailed-2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.418