(21 nodes) Hair follicle morphogenesis network (Tursiops truncatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FGF10	Fibroblast growth factor 10. (142 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	INTU	Protein inturned. (931 aa)
	FST	Follistatin isoform X2. (343 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (449 aa)
	KRT17	Keratin, type I cytoskeletal 17; Belongs to the intermediate filament family. (420 aa)
	TMEM79	Transmembrane protein 79. (395 aa)
	SNAI1	Snail family transcriptional repressor 1. (264 aa)
	PLA2G10	Phospholipase A(2). (128 aa)
	KRT12	Keratin, type I cytoskeletal 12 isoform X1; Belongs to the intermediate filament family. (490 aa)
	BCL2	Apoptosis regulator Bcl-2 isoform X1. (233 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	NOTCH1	Neurogenic locus notch homolog protein 1. (2527 aa)
	NGFR	Tumor necrosis factor receptor superfamily member 16. (427 aa)
	EXT1	Exostosin-1; Belongs to the glycosyltransferase 47 family. (746 aa)
	SMO	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	GORAB	LOW QUALITY PROTEIN: RAB6-interacting golgin. (395 aa)
	ENSTTRP00000009296	annotation not available (181 aa)
	SOSTDC1	Sclerostin domain-containing protein 1. (229 aa)
	WNT10A	Wnt family member 10A. (417 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2	CTNNB1	ENSTTRP00000004766	ENSTTRP00000005764	Apoptosis regulator Bcl-2 isoform X1.	Catenin beta-1.	0.707
BCL2	NOTCH1	ENSTTRP00000004766	ENSTTRP00000007173	Apoptosis regulator Bcl-2 isoform X1.	Neurogenic locus notch homolog protein 1.	0.551
BCL2	SHH	ENSTTRP00000004766	ENSTTRP00000013015	Apoptosis regulator Bcl-2 isoform X1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.418
CTNNB1	BCL2	ENSTTRP00000005764	ENSTTRP00000004766	Catenin beta-1.	Apoptosis regulator Bcl-2 isoform X1.	0.707
CTNNB1	ENSTTRP00000009296	ENSTTRP00000005764	ENSTTRP00000009296	Catenin beta-1.	annotation not available	0.436
CTNNB1	FGF10	ENSTTRP00000005764	ENSTTRP00000009805	Catenin beta-1.	Fibroblast growth factor 10.	0.576
CTNNB1	FGF7	ENSTTRP00000005764	ENSTTRP00000008275	Catenin beta-1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.552
CTNNB1	NOTCH1	ENSTTRP00000005764	ENSTTRP00000007173	Catenin beta-1.	Neurogenic locus notch homolog protein 1.	0.757
CTNNB1	SHH	ENSTTRP00000005764	ENSTTRP00000013015	Catenin beta-1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.683
CTNNB1	SMO	ENSTTRP00000005764	ENSTTRP00000008000	Catenin beta-1.	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family.	0.565
CTNNB1	SNAI1	ENSTTRP00000005764	ENSTTRP00000001905	Catenin beta-1.	Snail family transcriptional repressor 1.	0.669
CTNNB1	WNT10A	ENSTTRP00000005764	ENSTTRP00000009467	Catenin beta-1.	Wnt family member 10A.	0.654
ENSTTRP00000009296	CTNNB1	ENSTTRP00000009296	ENSTTRP00000005764	annotation not available	Catenin beta-1.	0.436
FGF10	CTNNB1	ENSTTRP00000009805	ENSTTRP00000005764	Fibroblast growth factor 10.	Catenin beta-1.	0.576
FGF10	FGF7	ENSTTRP00000009805	ENSTTRP00000008275	Fibroblast growth factor 10.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.591
FGF10	FST	ENSTTRP00000009805	ENSTTRP00000011717	Fibroblast growth factor 10.	Follistatin isoform X2.	0.575
FGF10	NGFR	ENSTTRP00000009805	ENSTTRP00000007552	Fibroblast growth factor 10.	Tumor necrosis factor receptor superfamily member 16.	0.861
FGF10	SHH	ENSTTRP00000009805	ENSTTRP00000013015	Fibroblast growth factor 10.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.834
FGF7	CTNNB1	ENSTTRP00000008275	ENSTTRP00000005764	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Catenin beta-1.	0.552
FGF7	FGF10	ENSTTRP00000008275	ENSTTRP00000009805	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 10.	0.591