(85 nodes) RNA 3-end processing network (Tursiops truncatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSTTRP00000016164	annotation not available (195 aa)
	INTS1	Integrator complex subunit 1. (2185 aa)
	ENSTTRP00000016165	annotation not available (194 aa)
	CPSF3	Cleavage and polyadenylation specificity factor subunit 3 isoform X5. (683 aa)
	CSTF1	Cleavage stimulation factor subunit 1. (431 aa)
	SCAF8	Protein SCAF8 isoform X2. (1259 aa)
	SYMPK	Symplekin. (1275 aa)
	CPSF6	Cleavage and polyadenylation specificity factor subunit 6 isoform X2. (566 aa)
	CSTF2	Cleavage stimulation factor subunit 2. (577 aa)
	NCBP1	Nuclear cap-binding protein subunit 1 isoform X1. (790 aa)
	ERI2	ERI1 exoribonuclease 2 isoform X1. (680 aa)
	CSTF3	Cleavage stimulation factor subunit 3 isoform X1. (714 aa)
	LEO1	RNA polymerase-associated protein LEO1 isoform X1. (666 aa)
	FBLL1	rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1. (335 aa)
	TUT4	Terminal uridylyltransferase 4 isoform X5. (1647 aa)
	AHCYL1	Adenosylhomocysteinase. (527 aa)
	FIP1L1	pre-mRNA 3'-end-processing factor FIP1 isoform X4. (550 aa)
	ENSTTRP00000014518	annotation not available (141 aa)
	INTS6L	Integrator complex subunit 6-like isoform X3. (851 aa)
	PCF11	pre-mRNA cleavage complex 2 protein Pcf11 isoform X2. (1491 aa)
	EXOSC2	Exosome complex component RRP4. (289 aa)
	ZC3H3	Zinc finger CCCH domain-containing protein 3. (884 aa)
	TRMT10C	Mitochondrial ribonuclease P protein 1. (404 aa)
	LIN28B	Protein lin-28 homolog B isoform X3. (275 aa)
	PNPT1	Polyribonucleotide nucleotidyltransferase 1, mitochondrial isoform X1. (729 aa)
	RPRD1B	Regulation of nuclear pre-mRNA domain-containing protein 1B isoform X1. (324 aa)
	MTPAP	Mitochondrial poly(A) polymerase. (529 aa)
	NUDT21	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (227 aa)
	TENT4B	Non-canonical poly(A) RNA polymerase PAPD5 isoform X1. (475 aa)
	ERI3	ERI1 exoribonuclease 3 isoform X2. (364 aa)
	TENT2	poly(A) RNA polymerase GLD2 isoform X1. (484 aa)
	EXOSC5	Exosome complex component RRP46. (235 aa)
	TENT4A	Non-canonical poly(A) RNA polymerase PAPD7 isoform X1. (540 aa)
	ELAC1	Zinc phosphodiesterase ELAC protein 1. (303 aa)
	POLR3K	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (108 aa)
	INTS14	Von Willebrand factor A domain-containing protein 9 isoform X1. (487 aa)
	EXOSC3	Exosome complex component RRP40 isoform X1. (275 aa)
	WDR33	pre-mRNA 3' end processing protein WDR33 isoform X6. (1328 aa)
	HSD17B10	3-hydroxyacyl-CoA dehydrogenase type-2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (258 aa)
	RPS21	40S ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family. (96 aa)
	CPSF7	Cleavage and polyadenylation specificity factor subunit 7 isoform X3. (452 aa)
	SLBP	Histone RNA hairpin-binding protein isoform X1. (216 aa)
	RPRD2	Regulation of nuclear pre-mRNA domain-containing protein 2. (1429 aa)
	INTS6	Integrator complex subunit 6 isoform X1. (888 aa)
	CDC73	Parafibromin. (530 aa)
	INTS9	Integrator complex subunit 9 isoform X4. (658 aa)
	TOE1	Target of EGR1 protein 1 isoform X1. (509 aa)
	MBLAC1	Metallo-beta-lactamase domain-containing protein 1. (267 aa)
	CPSF2	Cleavage and polyadenylation specificity factor subunit 2. (780 aa)
	ENSTTRP00000007988	annotation not available (265 aa)
	SUPV3L1	ATP-dependent RNA helicase SUPV3L1, mitochondrial isoform X1. (784 aa)
	DKC1	Dyskerin pseudouridine synthase 1. (505 aa)
	EXOSC8	Exosome complex component RRP43. (271 aa)
	TRNT1	CCA tRNA nucleotidyltransferase 1, mitochondrial; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (434 aa)
	INTS12	Integrator complex subunit 12 isoform X1. (458 aa)
	EXOSC7	Exosome complex component RRP42. (291 aa)
	RPRD1A	Regulation of nuclear pre-mRNA domain-containing protein 1A isoform X1. (312 aa)
	ERI1	3'-5' exoribonuclease 1. (349 aa)
	LSM11	U7 snRNA-associated Sm-like protein LSm11. (264 aa)
	PAPOLG	poly(A) polymerase gamma isoform X1. (741 aa)
	PAPOLA	Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (742 aa)
	CPSF4L	Putative cleavage and polyadenylation specificity factor subunit 4-like protein. (151 aa)
	LARP7	La-related protein 7 isoform X1. (519 aa)
	INTS8	Integrator complex subunit 8. (970 aa)
	INTS2	Integrator complex subunit 2 isoform X1. (1200 aa)
	TUT7	Terminal uridylyltransferase 7 isoform X5. (1481 aa)
	ENSTTRP00000003760	annotation not available (177 aa)
	FBL	rRNA 2'-O-methyltransferase fibrillarin. (323 aa)
	APLP1	Amyloid-like protein 1. (646 aa)
	PAF1	PAF1 homolog, Paf1/RNA polymerase II complex component. (526 aa)
	CSTF2T	Cleavage stimulation factor subunit 2 tau variant. (609 aa)
	APP	Amyloid beta A4 protein isoform X1. (763 aa)
	CPSF4	Cleavage and polyadenylation specificity factor subunit 4 isoform X7. (269 aa)
	LOC101320538	Pentatricopeptide repeat-containing protein 1, mitochondrial isoform X2. (697 aa)
	ELAC2	Zinc phosphodiesterase ELAC protein 2 isoform X3. (812 aa)
	PARN	poly(A)-specific ribonuclease PARN isoform X2. (627 aa)
	INTS5	Integrator complex subunit 5. (1008 aa)
	LOC101326630	Speckle targeted PIP5K1A-regulated poly(A) polymerase isoform X3. (871 aa)
	SSB	Lupus La protein isoform X1. (405 aa)
	CLP1	Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...] (425 aa)
	INTS7	Integrator complex subunit 7. (930 aa)
	CPSF1	Cleavage and polyadenylation specificity factor subunit 1. (1442 aa)
	EXOSC9	Exosome complex component RRP45. (456 aa)
	EXOSC10	Exosome component 10 isoform X2. (886 aa)
	ZNF473	Zinc finger protein 473 isoform X1. (924 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHCYL1	ELAC1	ENSTTRP00000015209	ENSTTRP00000011472	Adenosylhomocysteinase.	Zinc phosphodiesterase ELAC protein 1.	0.562
AHCYL1	PNPT1	ENSTTRP00000015209	ENSTTRP00000000027	Adenosylhomocysteinase.	Polyribonucleotide nucleotidyltransferase 1, mitochondrial isoform X1.	0.453
APP	HSD17B10	ENSTTRP00000002907	ENSTTRP00000010854	Amyloid beta A4 protein isoform X1.	3-hydroxyacyl-CoA dehydrogenase type-2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.558
CDC73	CPSF3	ENSTTRP00000008818	ENSTTRP00000000813	Parafibromin.	Cleavage and polyadenylation specificity factor subunit 3 isoform X5.	0.424
CDC73	INTS14	ENSTTRP00000008818	ENSTTRP00000011259	Parafibromin.	Von Willebrand factor A domain-containing protein 9 isoform X1.	0.610
CDC73	LARP7	ENSTTRP00000008818	ENSTTRP00000004937	Parafibromin.	La-related protein 7 isoform X1.	0.488
CDC73	LEO1	ENSTTRP00000008818	ENSTTRP00000015407	Parafibromin.	RNA polymerase-associated protein LEO1 isoform X1.	0.999
CDC73	LSM11	ENSTTRP00000008818	ENSTTRP00000006100	Parafibromin.	U7 snRNA-associated Sm-like protein LSm11.	0.674
CDC73	NCBP1	ENSTTRP00000008818	ENSTTRP00000000475	Parafibromin.	Nuclear cap-binding protein subunit 1 isoform X1.	0.610
CDC73	PAF1	ENSTTRP00000008818	ENSTTRP00000003335	Parafibromin.	PAF1 homolog, Paf1/RNA polymerase II complex component.	0.999
CDC73	POLR3K	ENSTTRP00000008818	ENSTTRP00000011418	Parafibromin.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.	0.594
CDC73	SYMPK	ENSTTRP00000008818	ENSTTRP00000013565	Parafibromin.	Symplekin.	0.629
CLP1	CPSF1	ENSTTRP00000001967	ENSTTRP00000001821	Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...]	Cleavage and polyadenylation specificity factor subunit 1.	0.873
CLP1	CPSF2	ENSTTRP00000001967	ENSTTRP00000008244	Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...]	Cleavage and polyadenylation specificity factor subunit 2.	0.909
CLP1	CPSF3	ENSTTRP00000001967	ENSTTRP00000000813	Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...]	Cleavage and polyadenylation specificity factor subunit 3 isoform X5.	0.900
CLP1	CPSF4	ENSTTRP00000001967	ENSTTRP00000002821	Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...]	Cleavage and polyadenylation specificity factor subunit 4 isoform X7.	0.850
CLP1	CPSF4L	ENSTTRP00000001967	ENSTTRP00000004940	Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...]	Putative cleavage and polyadenylation specificity factor subunit 4-like protein.	0.850
CLP1	CPSF6	ENSTTRP00000001967	ENSTTRP00000013210	Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...]	Cleavage and polyadenylation specificity factor subunit 6 isoform X2.	0.826
CLP1	CPSF7	ENSTTRP00000001967	ENSTTRP00000010512	Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...]	Cleavage and polyadenylation specificity factor subunit 7 isoform X3.	0.772
CLP1	CSTF1	ENSTTRP00000001967	ENSTTRP00000014099	Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...]	Cleavage stimulation factor subunit 1.	0.812