(26 nodes) Regulation of intracellular estrogen receptor signaling pathway network (Tursiops truncatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	UFL1	E3 UFM1-protein ligase 1 isoform X1. (791 aa)
	LATS1	Serine/threonine-protein kinase LATS1. (958 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1512 aa)
	CNOT1	CCR4-NOT transcription complex subunit 1 isoform X4. (2376 aa)
	CNOT9	Cell differentiation protein RCD1 homolog. (299 aa)
	DDRGK1	DDRGK domain-containing protein 1. (315 aa)
	AR	Androgen receptor. (886 aa)
	FSHR	Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
	FOXA1	Hepatocyte nuclear factor 3-alpha. (442 aa)
	FOXH1	Forkhead box H1. (360 aa)
	PAK1	Serine/threonine-protein kinase PAK 1. (550 aa)
	DNAAF4	Dyslexia susceptibility 1 candidate gene 1 protein isoform X1. (416 aa)
	BRCA1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1825 aa)
	ZNF366	Zinc finger protein 366. (739 aa)
	UBA5	Ubiquitin-like modifier-activating enzyme 5 isoform X1. (404 aa)
	SRARP	Uncharacterized protein C1orf64 homolog. (170 aa)
	KANK2	KN motif and ankyrin repeat domain-containing protein 2. (739 aa)
	KMT2D	Histone-lysine N-methyltransferase 2D. (4855 aa)
	UFSP2	Ufm1-specific protease 2. (441 aa)
	PHB2	Prohibitin 2. (298 aa)
	CNOT2	CCR4-NOT transcription complex subunit 2 isoform X2. (542 aa)
	PAGR1	PAXIP1-associated glutamate-rich protein 1. (254 aa)
	YAP1	Transcriptional coactivator YAP1 isoform X4. (488 aa)
	VPS18	Vacuolar protein sorting-associated protein 18 homolog isoform X1. (973 aa)
	SRC	Proto-oncogene tyrosine-protein kinase Src. (538 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	BRCA1	ENSTTRP00000003976	ENSTTRP00000011139	Androgen receptor.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.687
AR	FOXA1	ENSTTRP00000003976	ENSTTRP00000002678	Androgen receptor.	Hepatocyte nuclear factor 3-alpha.	0.858
AR	FSHR	ENSTTRP00000003976	ENSTTRP00000003246	Androgen receptor.	Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.	0.493
AR	MED1	ENSTTRP00000003976	ENSTTRP00000008003	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.638
AR	SRC	ENSTTRP00000003976	ENSTTRP00000005378	Androgen receptor.	Proto-oncogene tyrosine-protein kinase Src.	0.663
BRCA1	AR	ENSTTRP00000011139	ENSTTRP00000003976	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Androgen receptor.	0.687
BRCA1	TP63	ENSTTRP00000011139	ENSTTRP00000011034	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.448
CNOT1	CNOT2	ENSTTRP00000008020	ENSTTRP00000004552	CCR4-NOT transcription complex subunit 1 isoform X4.	CCR4-NOT transcription complex subunit 2 isoform X2.	0.999
CNOT1	CNOT9	ENSTTRP00000008020	ENSTTRP00000010239	CCR4-NOT transcription complex subunit 1 isoform X4.	Cell differentiation protein RCD1 homolog.	0.999
CNOT2	CNOT1	ENSTTRP00000004552	ENSTTRP00000008020	CCR4-NOT transcription complex subunit 2 isoform X2.	CCR4-NOT transcription complex subunit 1 isoform X4.	0.999
CNOT2	CNOT9	ENSTTRP00000004552	ENSTTRP00000010239	CCR4-NOT transcription complex subunit 2 isoform X2.	Cell differentiation protein RCD1 homolog.	0.999
CNOT9	CNOT1	ENSTTRP00000010239	ENSTTRP00000008020	Cell differentiation protein RCD1 homolog.	CCR4-NOT transcription complex subunit 1 isoform X4.	0.999
CNOT9	CNOT2	ENSTTRP00000010239	ENSTTRP00000004552	Cell differentiation protein RCD1 homolog.	CCR4-NOT transcription complex subunit 2 isoform X2.	0.999
DDRGK1	UBA5	ENSTTRP00000008866	ENSTTRP00000014708	DDRGK domain-containing protein 1.	Ubiquitin-like modifier-activating enzyme 5 isoform X1.	0.673
DDRGK1	UFL1	ENSTTRP00000008866	ENSTTRP00000005482	DDRGK domain-containing protein 1.	E3 UFM1-protein ligase 1 isoform X1.	0.955
DDRGK1	UFSP2	ENSTTRP00000008866	ENSTTRP00000004441	DDRGK domain-containing protein 1.	Ufm1-specific protease 2.	0.617
DDRGK1	ZNF366	ENSTTRP00000008866	ENSTTRP00000011243	DDRGK domain-containing protein 1.	Zinc finger protein 366.	0.480
FOXA1	AR	ENSTTRP00000002678	ENSTTRP00000003976	Hepatocyte nuclear factor 3-alpha.	Androgen receptor.	0.858
FSHR	AR	ENSTTRP00000003246	ENSTTRP00000003976	Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.	Androgen receptor.	0.493
FSHR	YAP1	ENSTTRP00000003246	ENSTTRP00000011064	Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.	Transcriptional coactivator YAP1 isoform X4.	0.420