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BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1825 aa) | ||||
KANK2 | KN motif and ankyrin repeat domain-containing protein 2. (739 aa) | ||||
ZNF366 | Zinc finger protein 366. (739 aa) | ||||
TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) | ||||
VPS18 | Vacuolar protein sorting-associated protein 18 homolog isoform X1. (973 aa) | ||||
CNOT9 | Cell differentiation protein RCD1 homolog. (299 aa) | ||||
CNOT1 | CCR4-NOT transcription complex subunit 1 isoform X4. (2376 aa) | ||||
CNOT2 | CCR4-NOT transcription complex subunit 2 isoform X2. (542 aa) | ||||
PHB2 | Prohibitin 2. (298 aa) | ||||
FOXH1 | Forkhead box H1. (360 aa) |