STRINGSTRING
BRCA1 BRCA1 KANK2 KANK2 ZNF366 ZNF366 TP63 TP63 VPS18 VPS18 CNOT9 CNOT9 CNOT1 CNOT1 CNOT2 CNOT2 PHB2 PHB2 FOXH1 FOXH1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1825 aa)
KANK2KN motif and ankyrin repeat domain-containing protein 2. (739 aa)
ZNF366Zinc finger protein 366. (739 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
VPS18Vacuolar protein sorting-associated protein 18 homolog isoform X1. (973 aa)
CNOT9Cell differentiation protein RCD1 homolog. (299 aa)
CNOT1CCR4-NOT transcription complex subunit 1 isoform X4. (2376 aa)
CNOT2CCR4-NOT transcription complex subunit 2 isoform X2. (542 aa)
PHB2Prohibitin 2. (298 aa)
FOXH1Forkhead box H1. (360 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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