STRINGSTRING
SFRP1 SFRP1 SIX2 SIX2 MED17 MED17 LIF LIF MED14 MED14 HES1 HES1 BRAF BRAF MED21 MED21 BCL9L BCL9L NODAL NODAL MED7 MED7 WNT9B WNT9B REST REST CUL4A CUL4A MED15 MED15 MED12 MED12 SOX9 SOX9 MED28 MED28 ZFP36L2 ZFP36L2 VPS72 VPS72 STAT3 STAT3 SALL4 SALL4 BMPR1A BMPR1A NR2E1 NR2E1 MED27 MED27 FGF10 FGF10 LOC101333926 LOC101333926 RIF1 RIF1 SMC1A SMC1A YAP1 YAP1 MED30 MED30 LIG4 LIG4 LDB2 LDB2 ENSTTRP00000014183 ENSTTRP00000014183 NIPBL NIPBL LRP5 LRP5 FGF4 FGF4 KLF10 KLF10 ENSTTRP00000000710 ENSTTRP00000000710
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SFRP1Secreted frizzled-related protein 1 isoform X2. (307 aa)
SIX2Homeobox protein SIX2. (168 aa)
MED17Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (651 aa)
LIFLeukemia inhibitory factor. (202 aa)
MED14Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1450 aa)
HES1Transcription factor HES-1. (280 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X4. (757 aa)
MED21Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (141 aa)
BCL9LBCL9 like. (1485 aa)
NODALNodal homolog. (348 aa)
MED7Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. (233 aa)
WNT9BWnt family member 9B. (330 aa)
RESTRE1-silencing transcription factor. (656 aa)
CUL4Acullin-4A isoform X1; Belongs to the cullin family. (677 aa)
MED15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (776 aa)
MED12Mediator of RNA polymerase II transcription subunit 12. (2173 aa)
SOX9Transcription factor SOX-9. (509 aa)
MED28Mediator of RNA polymerase II transcription subunit 28. (178 aa)
ZFP36L2mRNA decay activator protein ZFP36L2. (494 aa)
VPS72Vacuolar protein sorting-associated protein 72 homolog. (374 aa)
STAT3Signal transducer and activator of transcription. (767 aa)
SALL4Sal-like protein 4. (1005 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (419 aa)
MED27Mediator of RNA polymerase II transcription subunit 27 isoform X1. (311 aa)
FGF10Fibroblast growth factor 10. (142 aa)
LOC101333926RE1-silencing transcription factor-like. (974 aa)
RIF1Telomere-associated protein RIF1. (2463 aa)
SMC1AStructural maintenance of chromosomes protein. (1233 aa)
YAP1Transcriptional coactivator YAP1 isoform X4. (488 aa)
MED30Mediator of RNA polymerase II transcription subunit 30 isoform X2. (177 aa)
LIG4DNA ligase. (911 aa)
LDB2LIM domain-binding protein 2 isoform X1. (373 aa)
ENSTTRP00000014183annotation not available (197 aa)
NIPBLNipped-B protein. (2801 aa)
LRP5LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 5. (1582 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (147 aa)
KLF10Krueppel-like factor 10 isoform X1. (480 aa)
ENSTTRP00000000710annotation not available (306 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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