(20 nodes) miRNA-mediated gene silencing network (Tursiops truncatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CNOT1	CCR4-NOT transcription complex subunit 1 isoform X4. (2376 aa)
	EIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
	TRIM71	E3 ubiquitin-protein ligase TRIM71. (613 aa)
	AGO3	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (853 aa)
	AGO1	Protein argonaute-1 isoform X1; Belongs to the argonaute family. (854 aa)
	AGO4	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (854 aa)
	WTIP	Wilms tumor protein 1-interacting protein. (292 aa)
	AJUBA	LIM domain-containing protein ajuba. (537 aa)
	TNRC6A	Trinucleotide repeat-containing gene 6A protein isoform X9. (1955 aa)
	AGO2	Argonaute RISC catalytic component 2. (852 aa)
	ZFP36	ZFP36 ring finger protein. (322 aa)
	TNRC6B	Trinucleotide repeat-containing gene 6B protein isoform X8. (1756 aa)
	EIF4G1	Eukaryotic translation initiation factor 4 gamma 1. (1537 aa)
	RBM4	RNA-binding protein 4 isoform X1. (363 aa)
	TNRC6C	Trinucleotide repeat-containing gene 6C protein isoform X3. (1736 aa)
	LIMD1	LIM domain-containing protein 1 isoform X1. (654 aa)
	EIF4ENIF1	Eukaryotic translation initiation factor 4E transporter isoform X2. (980 aa)
	MOV10	Putative helicase MOV-10. (997 aa)
	DDX6	Probable ATP-dependent RNA helicase DDX6; Belongs to the DEAD box helicase family. (483 aa)
	XPO5	Exportin-5 isoform X1. (1204 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO1	AGO2	ENSTTRP00000014304	ENSTTRP00000002693	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Argonaute RISC catalytic component 2.	0.979
AGO1	AGO3	ENSTTRP00000014304	ENSTTRP00000014305	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.615
AGO1	AGO4	ENSTTRP00000014304	ENSTTRP00000014300	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.975
AGO1	CNOT1	ENSTTRP00000014304	ENSTTRP00000008020	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	CCR4-NOT transcription complex subunit 1 isoform X4.	0.406
AGO1	DDX6	ENSTTRP00000014304	ENSTTRP00000004057	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Probable ATP-dependent RNA helicase DDX6; Belongs to the DEAD box helicase family.	0.602
AGO1	MOV10	ENSTTRP00000014304	ENSTTRP00000009482	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Putative helicase MOV-10.	0.635
AGO1	TNRC6A	ENSTTRP00000014304	ENSTTRP00000001884	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Trinucleotide repeat-containing gene 6A protein isoform X9.	0.909
AGO1	TNRC6B	ENSTTRP00000014304	ENSTTRP00000010892	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Trinucleotide repeat-containing gene 6B protein isoform X8.	0.742
AGO1	TNRC6C	ENSTTRP00000014304	ENSTTRP00000010270	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Trinucleotide repeat-containing gene 6C protein isoform X3.	0.936
AGO1	XPO5	ENSTTRP00000014304	ENSTTRP00000006007	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Exportin-5 isoform X1.	0.580
AGO2	AGO1	ENSTTRP00000002693	ENSTTRP00000014304	Argonaute RISC catalytic component 2.	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	0.979
AGO2	AGO3	ENSTTRP00000002693	ENSTTRP00000014305	Argonaute RISC catalytic component 2.	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.963
AGO2	AGO4	ENSTTRP00000002693	ENSTTRP00000014300	Argonaute RISC catalytic component 2.	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.929
AGO2	CNOT1	ENSTTRP00000002693	ENSTTRP00000008020	Argonaute RISC catalytic component 2.	CCR4-NOT transcription complex subunit 1 isoform X4.	0.638
AGO2	DDX6	ENSTTRP00000002693	ENSTTRP00000004057	Argonaute RISC catalytic component 2.	Probable ATP-dependent RNA helicase DDX6; Belongs to the DEAD box helicase family.	0.808
AGO2	MOV10	ENSTTRP00000002693	ENSTTRP00000009482	Argonaute RISC catalytic component 2.	Putative helicase MOV-10.	0.813
AGO2	RBM4	ENSTTRP00000002693	ENSTTRP00000010582	Argonaute RISC catalytic component 2.	RNA-binding protein 4 isoform X1.	0.450
AGO2	TNRC6A	ENSTTRP00000002693	ENSTTRP00000001884	Argonaute RISC catalytic component 2.	Trinucleotide repeat-containing gene 6A protein isoform X9.	0.995
AGO2	TNRC6B	ENSTTRP00000002693	ENSTTRP00000010892	Argonaute RISC catalytic component 2.	Trinucleotide repeat-containing gene 6B protein isoform X8.	0.772
AGO2	TNRC6C	ENSTTRP00000002693	ENSTTRP00000010270	Argonaute RISC catalytic component 2.	Trinucleotide repeat-containing gene 6C protein isoform X3.	0.944