(17 nodes) Middle ear morphogenesis network (Tursiops truncatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	OSR1	Protein odd-skipped-related 1. (267 aa)
	SIX2	Homeobox protein SIX2. (168 aa)
	EDNRA	Endothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	ENSTTRP00000003397	annotation not available (173 aa)
	EDN1	Endothelin-1. (202 aa)
	PRRX1	Paired mesoderm homeobox protein 1. (164 aa)
	HOXA2	Homeobox protein Hox-A2. (295 aa)
	OSR2	Protein odd-skipped-related 2. (312 aa)
	GSC	Homeobox protein goosecoid. (256 aa)
	PRKRA	Interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform X1. (261 aa)
	INSIG2	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (238 aa)
	MSX1	Homeobox protein MSX-1. (303 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (589 aa)
	SIX1	Homeobox protein SIX1. (284 aa)
	NAGLU	alpha-N-acetylglucosaminidase. (744 aa)
	ENSTTRP00000015751	annotation not available (328 aa)
	TSHZ1	Teashirt homolog 1. (1032 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EDN1	EDNRA	ENSTTRP00000005761	ENSTTRP00000002303	Endothelin-1.	Endothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family.	0.999
EDNRA	EDN1	ENSTTRP00000002303	ENSTTRP00000005761	Endothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family.	Endothelin-1.	0.999
EYA1	SIX1	ENSTTRP00000011780	ENSTTRP00000013114	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Homeobox protein SIX1.	0.907
EYA1	SIX2	ENSTTRP00000011780	ENSTTRP00000001018	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Homeobox protein SIX2.	0.836
EYA1	TSHZ1	ENSTTRP00000011780	ENSTTRP00000016319	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Teashirt homolog 1.	0.494
MSX1	OSR2	ENSTTRP00000011517	ENSTTRP00000007074	Homeobox protein MSX-1.	Protein odd-skipped-related 2.	0.555
MSX1	SIX1	ENSTTRP00000011517	ENSTTRP00000013114	Homeobox protein MSX-1.	Homeobox protein SIX1.	0.512
OSR2	MSX1	ENSTTRP00000007074	ENSTTRP00000011517	Protein odd-skipped-related 2.	Homeobox protein MSX-1.	0.555
SIX1	EYA1	ENSTTRP00000013114	ENSTTRP00000011780	Homeobox protein SIX1.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.907
SIX1	MSX1	ENSTTRP00000013114	ENSTTRP00000011517	Homeobox protein SIX1.	Homeobox protein MSX-1.	0.512
SIX1	TSHZ1	ENSTTRP00000013114	ENSTTRP00000016319	Homeobox protein SIX1.	Teashirt homolog 1.	0.527
SIX2	EYA1	ENSTTRP00000001018	ENSTTRP00000011780	Homeobox protein SIX2.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.836
TSHZ1	EYA1	ENSTTRP00000016319	ENSTTRP00000011780	Teashirt homolog 1.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.494
TSHZ1	SIX1	ENSTTRP00000016319	ENSTTRP00000013114	Teashirt homolog 1.	Homeobox protein SIX1.	0.527