(137 nodes) Regulation of cysteine-type endopeptidase activity involved in apoptotic process network (Tursiops truncatus)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	S100A8	Protein S100; Belongs to the S-100 family. (89 aa)
	S100A9	Protein S100-A9; Belongs to the S-100 family. (112 aa)
	THBS1	Thrombospondin-1. (1144 aa)
	PML	Protein PML isoform X2. (871 aa)
	XDH	Xanthine dehydrogenase/oxidase. (1332 aa)
	HGF	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (727 aa)
	aqp1	Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (251 aa)
	NLRC4	NLR family CARD domain-containing protein 4 isoform X1. (1025 aa)
	LAPTM5	Lysosomal-associated transmembrane protein 5. (264 aa)
	HIP1	Huntingtin-interacting protein 1. (1024 aa)
	BIRC2	Baculoviral IAP repeat-containing protein 2. (621 aa)
	BAX	Apoptosis regulator BAX. (198 aa)
	LAMTOR5	Ragulator complex protein LAMTOR5. (159 aa)
	BCL10	B-cell lymphoma/leukemia 10. (233 aa)
	CYR61	Protein CYR61. (382 aa)
	ACER2	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
	BIRC7	Baculoviral IAP repeat containing 7. (296 aa)
	DDX3X	ATP-dependent RNA helicase DDX3X; Belongs to the DEAD box helicase family. (645 aa)
	MTCH1	Mitochondrial carrier homolog 1-like; Belongs to the mitochondrial carrier (TC 2.A.29) family. (389 aa)
	XIAP	E3 ubiquitin-protein ligase XIAP isoform X2. (497 aa)
	RPS6KA3	Ribosomal protein S6 kinase. (740 aa)
	ENSTTRP00000002090	annotation not available (193 aa)
	MAP3K5	Mitogen-activated protein kinase kinase kinase 5 isoform X2. (1362 aa)
	TFAP4	Transcription factor AP-4. (333 aa)
	NR4A1	Nuclear receptor subfamily 4 group A member 1. (632 aa)
	BIRC3	Baculoviral IAP repeat-containing protein 3. (601 aa)
	SMAD3	Mothers against decapentaplegic homolog 3. (291 aa)
	NODAL	Nodal homolog. (348 aa)
	CRADD	Death domain-containing protein CRADD isoform X1. (199 aa)
	SYK	Tyrosine-protein kinase. (629 aa)
	REST	RE1-silencing transcription factor. (656 aa)
	AIFM1	Apoptosis inducing factor mitochondria associated 1. (613 aa)
	CASP8AP2	CASP8-associated protein 2 isoform X2. (1962 aa)
	DLC1	Rho GTPase-activating protein 7. (1525 aa)
	PDCD5	Programmed cell death protein 5. (125 aa)
	GRAMD4	GRAM domain-containing protein 4. (521 aa)
	MICAL1	Protein-methionine sulfoxide oxidase MICAL1. (1066 aa)
	MGMT	methylated-DNA--protein-cysteine methyltransferase. (211 aa)
	SFRP2	Secreted frizzled-related protein 2. (294 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1246 aa)
	FIS1	Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
	MUL1	Mitochondrial ubiquitin ligase activator of NFKB 1. (352 aa)
	LOC101330933-2	Baculoviral IAP repeat-containing protein 1 isoform X6. (1061 aa)
	CAAP1	Caspase activity and apoptosis inhibitor 1 isoform X1. (363 aa)
	GSN	Gelsolin. (770 aa)
	PIH1D1	PIH1 domain-containing protein 1 isoform X2. (290 aa)
	SRC	Proto-oncogene tyrosine-protein kinase Src. (538 aa)
	CLEC7A	C-type lectin domain family 7 member A isoform X1. (243 aa)
	RPS3	40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
	P2RX1	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
	ATP2A3	Sarcoplasmic/endoplasmic reticulum calcium ATPase 3; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1060 aa)
	TNFSF14	Tumor necrosis factor ligand superfamily member 14. (241 aa)
	ENSTTRP00000005668	annotation not available (168 aa)
	BCL2L11	Bcl-2-like protein 11 isoform X1. (196 aa)
	RPS6KA1	Non-specific serine/threonine protein kinase. (744 aa)
	ENSTTRP00000006381	annotation not available (382 aa)
	PLAUR	Plasminogen activator, urokinase receptor. (330 aa)
	SH3RF1	E3 ubiquitin-protein ligase SH3RF1 isoform X2. (840 aa)
	BAK1	BCL2 antagonist/killer 1. (212 aa)
	CSNK2A1	LOW QUALITY PROTEIN: casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (394 aa)
	F2R	Proteinase-activated receptor 1 isoform X1; Belongs to the G-protein coupled receptor 1 family. (426 aa)
	SIAH2	Siah E3 ubiquitin protein ligase 2. (185 aa)
	CARD9	Caspase recruitment domain-containing protein 9. (539 aa)
	PPM1F	Protein phosphatase 1F. (414 aa)
	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1. (758 aa)
	CFLAR	CASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family. (482 aa)
	CASP10	Caspase-10; Belongs to the peptidase C14A family. (515 aa)
	NGFR	Tumor necrosis factor receptor superfamily member 16. (427 aa)
	CDKN2D	Cyclin-dependent kinase 4 inhibitor D. (161 aa)
	FAS	Tumor necrosis factor receptor superfamily member 6 isoform X2. (350 aa)
	RACK1	Receptor of activated protein C kinase 1. (346 aa)
	F3	Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (291 aa)
	IFI6	Interferon alpha-inducible protein 6 isoform X1. (125 aa)
	CASP8	Caspase-8 isoform X2; Belongs to the peptidase C14A family. (491 aa)
	GAS6	Growth arrest specific 6. (719 aa)
	CD44	CD44 antigen isoform X1. (742 aa)
	ROBO1	Roundabout homolog 1 isoform X4. (1622 aa)
	PRR7	Proline-rich protein 7. (267 aa)
	LCK	Tyrosine-protein kinase Lck. (536 aa)
	BOK	Bcl-2-related ovarian killer protein isoform X2. (137 aa)
	NDUFA13	LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13. (227 aa)
	YJEFN3	YjeF N-terminal domain containing 3. (303 aa)
	ENSTTRP00000009720	annotation not available (206 aa)
	BAD	BCL2 associated agonist of cell death. (150 aa)
	PRDX5	Peroxiredoxin 5. (219 aa)
	EGLN3	Egl nine homolog 3. (319 aa)
	CRYAB	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
	USP47	Ubiquitin carboxyl-terminal hydrolase 47 isoform X1; Belongs to the peptidase C19 family. (1362 aa)
	CASP2	Caspase-2 isoform X2; Belongs to the peptidase C14A family. (452 aa)
	VIL1	Villin 1. (825 aa)
	ANP32B	Acidic leucine-rich nuclear phosphoprotein 32 family member B. (235 aa)
	LOC101333926	RE1-silencing transcription factor-like. (974 aa)
	BIRC5	Baculoviral IAP repeat-containing protein 5. (141 aa)
	PRDX3	Thioredoxin-dependent peroxide reductase, mitochondrial isoform X1. (257 aa)
	NOD1	Nucleotide-binding oligomerization domain-containing protein 1 isoform X1. (953 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	BCAP31	B-cell receptor-associated protein 31 isoform X2. (245 aa)
	ENSTTRP00000011347	annotation not available (185 aa)
	MMP9	Matrix metalloproteinase-9. (670 aa)
	DELE1	Death ligand signal enhancer isoform X2. (515 aa)
	PTGS2	Prostaglandin G/H synthase 2. (603 aa)
	NKX3-1	Homeobox protein Nkx-3.1. (138 aa)
	PIDD1	P53-induced death domain-containing protein 1. (913 aa)
	HTRA2	Serine protease HTRA2, mitochondrial. (457 aa)
	DAPK1	Death-associated protein kinase 1 isoform X2. (1449 aa)
	TNFSF10	Tumor necrosis factor ligand superfamily member. (298 aa)
	FAM162A	Protein FAM162A. (141 aa)
	FNIP1	Folliculin-interacting protein 1 isoform X2. (1160 aa)
	MT3	Keratin-associated protein 5-8; Belongs to the metallothionein superfamily. Type 1 family. (67 aa)
	PAK2	Non-specific serine/threonine protein kinase. (523 aa)
	UACA	Uveal autoantigen with coiled-coil domains and ankyrin repeats isoform X1. (1416 aa)
	RNF34	E3 ubiquitin-protein ligase RNF34 isoform X1. (375 aa)
	CD27	CD27 antigen isoform X1. (251 aa)
	DHCR24	Delta(24)-sterol reductase isoform X1. (516 aa)
	COL4A3	Collagen alpha-3(IV) chain. (1658 aa)
	PAX2	LOW QUALITY PROTEIN: paired box protein Pax-2. (419 aa)
	TNFSF15	Tumor necrosis factor ligand superfamily member 15 isoform X1. (250 aa)
	SENP1	Sentrin-specific protease 1 isoform X2. (673 aa)
	RFFL	E3 ubiquitin-protein ligase rififylin isoform X6. (356 aa)
	NLE1	Notchless protein homolog 1. (430 aa)
	ENSTTRP00000014732	annotation not available (304 aa)
	ACVR1C	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (492 aa)
	PARK7	Protein deglycase DJ-1. (189 aa)
	CASP9	Caspase-9; Belongs to the peptidase C14A family. (365 aa)
	DIABLO	Diablo homolog, mitochondrial isoform X1. (237 aa)
	ENSTTRP00000015007	annotation not available (215 aa)
	HIP1R	Huntingtin interacting protein 1 related. (1030 aa)
	ENSTTRP00000015100	annotation not available (189 aa)
	EPHA7	Ephrin type-A receptor 7 isoform X1. (998 aa)
	SIRT1	NAD-dependent protein deacetylase sirtuin-1 isoform X1. (616 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa)
	TNFAIP8	Tumor necrosis factor alpha-induced protein 8 isoform X1. (188 aa)
	IFT57	Intraflagellar transport protein 57 homolog. (427 aa)
	CTSH	Cathepsin H. (335 aa)
	SFN	Stratifin. (248 aa)
	INTS1	Integrator complex subunit 1. (2185 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVR1C	NODAL	ENSTTRP00000014763	ENSTTRP00000002983	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Nodal homolog.	0.861
ACVR1C	SMAD3	ENSTTRP00000014763	ENSTTRP00000002846	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Mothers against decapentaplegic homolog 3.	0.928
AIFM1	BAK1	ENSTTRP00000003641	ENSTTRP00000006555	Apoptosis inducing factor mitochondria associated 1.	BCL2 antagonist/killer 1.	0.697
AIFM1	BAX	ENSTTRP00000003641	ENSTTRP00000001176	Apoptosis inducing factor mitochondria associated 1.	Apoptosis regulator BAX.	0.901
AIFM1	BCL2L11	ENSTTRP00000003641	ENSTTRP00000005763	Apoptosis inducing factor mitochondria associated 1.	Bcl-2-like protein 11 isoform X1.	0.491
AIFM1	BIRC3	ENSTTRP00000003641	ENSTTRP00000002688	Apoptosis inducing factor mitochondria associated 1.	Baculoviral IAP repeat-containing protein 3.	0.517
AIFM1	CASP9	ENSTTRP00000003641	ENSTTRP00000014940	Apoptosis inducing factor mitochondria associated 1.	Caspase-9; Belongs to the peptidase C14A family.	0.418
AIFM1	DIABLO	ENSTTRP00000003641	ENSTTRP00000014965	Apoptosis inducing factor mitochondria associated 1.	Diablo homolog, mitochondrial isoform X1.	0.427
AIFM1	TNFSF15	ENSTTRP00000003641	ENSTTRP00000014621	Apoptosis inducing factor mitochondria associated 1.	Tumor necrosis factor ligand superfamily member 15 isoform X1.	0.403
APAF1	BAK1	ENSTTRP00000004494	ENSTTRP00000006555	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 antagonist/killer 1.	0.792
APAF1	BAX	ENSTTRP00000004494	ENSTTRP00000001176	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Apoptosis regulator BAX.	0.744
APAF1	BCL2L11	ENSTTRP00000004494	ENSTTRP00000005763	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Bcl-2-like protein 11 isoform X1.	0.435
APAF1	BIRC2	ENSTTRP00000004494	ENSTTRP00000001095	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat-containing protein 2.	0.778
APAF1	BIRC3	ENSTTRP00000004494	ENSTTRP00000002688	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat-containing protein 3.	0.738
APAF1	BIRC5	ENSTTRP00000004494	ENSTTRP00000010289	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat-containing protein 5.	0.739
APAF1	BIRC7	ENSTTRP00000004494	ENSTTRP00000001705	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 7.	0.729
APAF1	BOK	ENSTTRP00000004494	ENSTTRP00000009298	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Bcl-2-related ovarian killer protein isoform X2.	0.671
APAF1	CASP10	ENSTTRP00000004494	ENSTTRP00000007378	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-10; Belongs to the peptidase C14A family.	0.896
APAF1	CASP2	ENSTTRP00000004494	ENSTTRP00000010195	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-2 isoform X2; Belongs to the peptidase C14A family.	0.955
APAF1	CASP8	ENSTTRP00000004494	ENSTTRP00000008268	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-8 isoform X2; Belongs to the peptidase C14A family.	0.964