(36 nodes) Negative regulation of DNA binding network (Tursiops truncatus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LHX2	LIM/homeobox protein Lhx2. (397 aa)
	MDFI	myoD family inhibitor isoform X2. (246 aa)
	HEY2	Hairy/enhancer-of-split related with YRPW motif protein 2. (336 aa)
	DDIT3	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (167 aa)
	MSX1	Homeobox protein MSX-1. (303 aa)
	ZFP90	Zinc finger protein 90 homolog isoform X2. (549 aa)
	JUN	Transcription factor AP-1; Belongs to the bZIP family. (321 aa)
	SIN3A	Paired amphipathic helix protein Sin3a isoform X1. (1211 aa)
	E2F1	Transcription factor E2F1 isoform X1. (437 aa)
	MAD2L2	Mitotic spindle assembly checkpoint protein MAD2B. (223 aa)
	ERCC4	DNA repair endonuclease XPF. (914 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (466 aa)
	WFIKKN1	WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1. (550 aa)
	GZMA	Granzyme A; Belongs to the peptidase S1 family. (260 aa)
	SMO	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
	LEF1	Lymphoid enhancer binding factor 1. (396 aa)
	ILRUN	Uncharacterized protein C6orf106 homolog. (206 aa)
	TNKS	Poly [ADP-ribose] polymerase. (1312 aa)
	RSF1	Remodeling and spacing factor 1 isoform X4. (1428 aa)
	FBXW7	F-box/WD repeat-containing protein 7 isoform X1. (707 aa)
	HABP4	Intracellular hyaluronan-binding protein 4. (415 aa)
	FBXW9	F-box and WD repeat domain containing 9. (487 aa)
	ANKRD33	Ankyrin repeat domain-containing protein 33. (445 aa)
	GATA1	Erythroid transcription factor. (383 aa)
	CTNNBIP1	Beta-catenin-interacting protein 1 isoform X1. (176 aa)
	HMGA2	High mobility group protein HMGI-C. (83 aa)
	WFIKKN2	WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2. (574 aa)
	HAND1	Heart- and neural crest derivatives-expressed protein 1. (218 aa)
	TFAP4	Transcription factor AP-4. (333 aa)
	NEK2	Serine/threonine-protein kinase Nek2. (445 aa)
	HAND2	Heart- and neural crest derivatives-expressed protein 2. (208 aa)
	ZNF462	Zinc finger protein 462 isoform X3. (2491 aa)
	SRI	Sorcin. (181 aa)
	ENSTTRP00000000580	annotation not available (155 aa)
	ANKRD33B	Ankyrin repeat domain-containing protein 33B isoform X2. (483 aa)
	HEY1	Hairy/enhancer-of-split related with YRPW motif protein 1 isoform X1. (193 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDIT3	JUN	ENSTTRP00000012419	ENSTTRP00000010932	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	Transcription factor AP-1; Belongs to the bZIP family.	0.511
E2F1	JUN	ENSTTRP00000009580	ENSTTRP00000010932	Transcription factor E2F1 isoform X1.	Transcription factor AP-1; Belongs to the bZIP family.	0.554
FBXW7	JUN	ENSTTRP00000006346	ENSTTRP00000010932	F-box/WD repeat-containing protein 7 isoform X1.	Transcription factor AP-1; Belongs to the bZIP family.	0.845
FBXW9	JUN	ENSTTRP00000005118	ENSTTRP00000010932	F-box and WD repeat domain containing 9.	Transcription factor AP-1; Belongs to the bZIP family.	0.602
GATA1	HAND2	ENSTTRP00000004388	ENSTTRP00000001282	Erythroid transcription factor.	Heart- and neural crest derivatives-expressed protein 2.	0.633
GATA1	JUN	ENSTTRP00000004388	ENSTTRP00000010932	Erythroid transcription factor.	Transcription factor AP-1; Belongs to the bZIP family.	0.406
HAND2	GATA1	ENSTTRP00000001282	ENSTTRP00000004388	Heart- and neural crest derivatives-expressed protein 2.	Erythroid transcription factor.	0.633
JUN	DDIT3	ENSTTRP00000010932	ENSTTRP00000012419	Transcription factor AP-1; Belongs to the bZIP family.	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.511
JUN	E2F1	ENSTTRP00000010932	ENSTTRP00000009580	Transcription factor AP-1; Belongs to the bZIP family.	Transcription factor E2F1 isoform X1.	0.554
JUN	FBXW7	ENSTTRP00000010932	ENSTTRP00000006346	Transcription factor AP-1; Belongs to the bZIP family.	F-box/WD repeat-containing protein 7 isoform X1.	0.845
JUN	FBXW9	ENSTTRP00000010932	ENSTTRP00000005118	Transcription factor AP-1; Belongs to the bZIP family.	F-box and WD repeat domain containing 9.	0.602
JUN	GATA1	ENSTTRP00000010932	ENSTTRP00000004388	Transcription factor AP-1; Belongs to the bZIP family.	Erythroid transcription factor.	0.406
LEF1	MSX1	ENSTTRP00000007673	ENSTTRP00000011517	Lymphoid enhancer binding factor 1.	Homeobox protein MSX-1.	0.708
LHX2	MSX1	ENSTTRP00000010421	ENSTTRP00000011517	LIM/homeobox protein Lhx2.	Homeobox protein MSX-1.	0.564
MSX1	LEF1	ENSTTRP00000011517	ENSTTRP00000007673	Homeobox protein MSX-1.	Lymphoid enhancer binding factor 1.	0.708
MSX1	LHX2	ENSTTRP00000011517	ENSTTRP00000010421	Homeobox protein MSX-1.	LIM/homeobox protein Lhx2.	0.564