STRINGSTRING
THBS1 THBS1 CD40 CD40 NTRK3 NTRK3 EPHA4 EPHA4 MAP3K10 MAP3K10 SH2B3 SH2B3 SPRY4 SPRY4 SFRP1 SFRP1 PDGFB PDGFB FZD10 FZD10 AJUBA AJUBA TMEM130 TMEM130 FGD2 FGD2 PAQR3 PAQR3 TPD52L1 TPD52L1 MAP3K13 MAP3K13 MAP3K11 MAP3K11 PRKCD PRKCD TRIB2 TRIB2 EPGN EPGN LRRK2 LRRK2 DUSP19 DUSP19 BMP2 BMP2 MAP3K5 MAP3K5 PDGFA PDGFA TRAF2 TRAF2 SORL1 SORL1 DVL3 DVL3 PIK3CG PIK3CG PTPRJ PTPRJ MAP2K6 MAP2K6 SYK SYK AGT AGT FGFR1 FGFR1 SFRP2 SFRP2 IRAK1 IRAK1 EGF EGF FGF1 FGF1 PTPN6 PTPN6 TRIB3 TRIB3 ERN2 ERN2 WNT5A WNT5A CCL19 CCL19 RPS3 RPS3 IL34 IL34 LOC109549336 LOC109549336 CAV3 CAV3 EDN1 EDN1 FZD4 FZD4 PIK3R6 PIK3R6 PIK3R5 PIK3R5 INPP5K INPP5K HYAL2 HYAL2 TGFA TGFA ADRA2A ADRA2A ERN1 ERN1 HGS HGS CBLC CBLC FLT1 FLT1 KSR1 KSR1 ENSTTRP00000007731 ENSTTRP00000007731 ERBB2 ERBB2 FGF18 FGF18 CDK12 CDK12 SMPD1 SMPD1 CAV1 CAV1 PTPRC PTPRC APOE APOE TRAF6 TRAF6 PAK1 PAK1 MAP4K2 MAP4K2 IRAK3 IRAK3 INSR INSR AXIN1 AXIN1 BMP4 BMP4 PSEN1 PSEN1 ROBO1 ROBO1 DAB2IP DAB2IP GBA GBA DUSP10 DUSP10 HMGCR HMGCR DVL2 DVL2 LOC109547947 LOC109547947 TNFSF11 TNFSF11 DUSP1 DUSP1 NEK10 NEK10 IL1B IL1B HRAS HRAS PDGFC PDGFC SPRY2 SPRY2 ENSTTRP00000011242 ENSTTRP00000011242 MAP3K4 MAP3K4 RASGRP1 RASGRP1 ENSTTRP00000011595 ENSTTRP00000011595 MST1R MST1R NOX4 NOX4 TGFB1 TGFB1 TAOK3 TAOK3 NOD2 NOD2 TNFRSF11A TNFRSF11A TSG101 TSG101 AGER AGER CD300A CD300A DTNBP1 DTNBP1 PTPN1 PTPN1 P2RX7 P2RX7 SOS1 SOS1 ADAM9 ADAM9 PDGFD PDGFD NUP62 NUP62 DUSP16 DUSP16 SPRY1 SPRY1 SASH1 SASH1 KIT KIT NF1 NF1 MAP3K7 MAP3K7 TRIB1 TRIB1 BMP7 BMP7 HTR2B HTR2B PDCD10 PDCD10 LAX1 LAX1 CDK5RAP3 CDK5RAP3 ENSTTRP00000015784 ENSTTRP00000015784 DUSP7 DUSP7 ADIPOQ ADIPOQ LYN LYN NUP62CL NUP62CL MAP3K12 MAP3K12 EGFR EGFR EZH2 EZH2 RGS14 RGS14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
THBS1Thrombospondin-1. (1144 aa)
CD40Tumor necrosis factor receptor superfamily member 5. (280 aa)
NTRK3Tyrosine-protein kinase receptor. (840 aa)
EPHA4Ephrin type-A receptor 4 isoform X1. (979 aa)
MAP3K10Mitogen-activated protein kinase kinase kinase 10. (948 aa)
SH2B3SH2B adapter protein 3 isoform X2. (558 aa)
SPRY4Protein sprouty homolog 4. (321 aa)
SFRP1Secreted frizzled-related protein 1 isoform X2. (307 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (240 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
AJUBALIM domain-containing protein ajuba. (537 aa)
TMEM130Transmembrane protein 130. (292 aa)
FGD2FYVE, RhoGEF and PH domain-containing protein 2 isoform X4. (687 aa)
PAQR3Progestin and adipoQ receptor family member 3 isoform X1. (309 aa)
TPD52L1Tumor protein D53 isoform X1. (204 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (964 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase 11. (735 aa)
PRKCDProtein kinase C delta. (671 aa)
TRIB2Tribbles homolog 2. (341 aa)
EPGNEpigen. (133 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2. (2526 aa)
DUSP19Dual specificity protein phosphatase 19 isoform X1; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (216 aa)
BMP2Bone morphogenetic protein 2. (388 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5 isoform X2. (1362 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (504 aa)
SORL1Sortilin-related receptor. (2205 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3. (498 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1103 aa)
PTPRJPeptidylprolyl isomerase. (1262 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
SYKTyrosine-protein kinase. (629 aa)
AGTAngiotensinogen; Belongs to the serpin family. (484 aa)
FGFR1Fibroblast growth factor receptor 1. (822 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
IRAK1LOW QUALITY PROTEIN: zinc finger protein 14-like. (708 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1205 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type 6. (620 aa)
TRIB3Tribbles homolog 3. (357 aa)
ERN2Serine/threonine-protein kinase/endoribonuclease IRE2. (897 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (470 aa)
CCL19C-C motif chemokine ligand 19. (109 aa)
RPS340S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
IL34Interleukin 34. (241 aa)
LOC109549336tenascin-X-like. (3808 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (192 aa)
EDN1Endothelin-1. (202 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (755 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5. (836 aa)
INPP5KInositol polyphosphate 5-phosphatase K isoform X2. (447 aa)
HYAL2Hyaluronidase. (476 aa)
TGFAProtransforming growth factor alpha isoform X1. (224 aa)
ADRA2Aalpha-2A adrenergic receptor. (448 aa)
ERN1Serine/threonine-protein kinase/endoribonuclease IRE1. (963 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (778 aa)
CBLCE3 ubiquitin-protein ligase CBL-C isoform X1. (337 aa)
FLT1Vascular endothelial growth factor receptor 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1318 aa)
KSR1Kinase suppressor of Ras 1. (841 aa)
ENSTTRP00000007731annotation not available (287 aa)
ERBB2Erb-b2 receptor tyrosine kinase 2. (1228 aa)
FGF18Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (207 aa)
CDK12Cyclin-dependent kinase 12 isoform X1. (1436 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (657 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (134 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X2. (1274 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (316 aa)
TRAF6TNF receptor associated factor 6. (523 aa)
PAK1Serine/threonine-protein kinase PAK 1. (550 aa)
MAP4K2Mitogen-activated protein kinase kinase kinase kinase 2. (818 aa)
IRAK3Interleukin-1 receptor-associated kinase 3 isoform X2. (597 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
AXIN1Axin-1 isoform X2. (866 aa)
BMP4Bone morphogenetic protein 4. (407 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (466 aa)
ROBO1Roundabout homolog 1 isoform X4. (1622 aa)
DAB2IPDAB2 interacting protein. (1177 aa)
GBAGlucosylceramidase. (394 aa)
DUSP10Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (480 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (884 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2 isoform X9. (736 aa)
LOC109547947Cystathionine beta-synthase-like. (561 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (318 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (366 aa)
NEK10Serine/threonine-protein kinase Nek10. (672 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (265 aa)
HRASGTPase HRas isoform X1. (189 aa)
PDGFCPlatelet-derived growth factor C. (345 aa)
SPRY2Protein sprouty homolog 2. (315 aa)
ENSTTRP00000011242annotation not available (843 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4 isoform X1. (1594 aa)
RASGRP1RAS guanyl-releasing protein 1 isoform X2. (738 aa)
ENSTTRP00000011595annotation not available (247 aa)
MST1RMacrophage-stimulating protein receptor isoform X5. (1361 aa)
NOX4NADPH oxidase 4. (577 aa)
TGFB1Transforming growth factor beta 1. (338 aa)
TAOK3Serine/threonine-protein kinase TAO3 isoform X1. (887 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1038 aa)
TNFRSF11ATumor necrosis factor receptor superfamily member 11A isoform X2. (562 aa)
TSG101Tumor susceptibility 101. (391 aa)
AGERAdvanced glycosylation end-product specific receptor. (418 aa)
CD300ACMRF35-like molecule 8. (282 aa)
DTNBP1Dysbindin. (330 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (428 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (551 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1304 aa)
ADAM9Disintegrin and metalloproteinase domain-containing protein 9 isoform X1. (819 aa)
PDGFDPlatelet-derived growth factor D isoform X1. (368 aa)
NUP62Nuclear pore glycoprotein p62. (516 aa)
DUSP16Dual specificity protein phosphatase 16. (610 aa)
SPRY1Protein sprouty homolog 1. (319 aa)
SASH1SAM and SH3 domain-containing protein 1 isoform X2. (1232 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (953 aa)
NF1Neurofibromin. (2814 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TRIB1Tribbles homolog 1. (368 aa)
BMP7Bone morphogenetic protein 7 isoform X2. (431 aa)
HTR2BLOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 2B. (479 aa)
PDCD10Programmed cell death protein 10. (212 aa)
LAX1Lymphocyte transmembrane adapter 1. (401 aa)
CDK5RAP3CDK5 regulatory subunit-associated protein 3 isoform X1. (505 aa)
ENSTTRP00000015784annotation not available (149 aa)
DUSP7Dual specificity protein phosphatase 7. (368 aa)
ADIPOQAdiponectin. (242 aa)
LYNTyrosine-protein kinase. (491 aa)
NUP62CLNucleoporin-62 C-terminal-like protein. (267 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12-like. (855 aa)
EGFRReceptor protein-tyrosine kinase. (1211 aa)
EZH2Histone-lysine N-methyltransferase EZH2 isoform X2. (751 aa)
RGS14Regulator of G-protein signaling 14 isoform X2. (499 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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