(41 nodes) Negative regulation of MAP kinase activity network (Tursiops truncatus)

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second shell of interactors

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proteins of unknown 3D structure

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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protein homology

Your Input:
	BMP7	Bone morphogenetic protein 7 isoform X2. (431 aa)
	RGS14	Regulator of G-protein signaling 14 isoform X2. (499 aa)
	NUP62CL	Nucleoporin-62 C-terminal-like protein. (267 aa)
	LYN	Tyrosine-protein kinase. (491 aa)
	ADIPOQ	Adiponectin. (242 aa)
	DUSP7	Dual specificity protein phosphatase 7. (368 aa)
	CDK5RAP3	CDK5 regulatory subunit-associated protein 3 isoform X1. (505 aa)
	LAX1	Lymphocyte transmembrane adapter 1. (401 aa)
	NF1	Neurofibromin. (2814 aa)
	SPRY1	Protein sprouty homolog 1. (319 aa)
	DUSP16	Dual specificity protein phosphatase 16. (610 aa)
	NUP62	Nuclear pore glycoprotein p62. (516 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (428 aa)
	CD300A	CMRF35-like molecule 8. (282 aa)
	SPRY2	Protein sprouty homolog 2. (315 aa)
	DUSP1	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (366 aa)
	HMGCR	3-hydroxy-3-methylglutaryl coenzyme A reductase. (884 aa)
	DUSP10	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (480 aa)
	GBA	Glucosylceramidase. (394 aa)
	DAB2IP	DAB2 interacting protein. (1177 aa)
	BMP4	Bone morphogenetic protein 4. (407 aa)
	IRAK3	Interleukin-1 receptor-associated kinase 3 isoform X2. (597 aa)
	APOE	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (316 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (134 aa)
	SMPD1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (657 aa)
	CBLC	E3 ubiquitin-protein ligase CBL-C isoform X1. (337 aa)
	HYAL2	Hyaluronidase. (476 aa)
	INPP5K	Inositol polyphosphate 5-phosphatase K isoform X2. (447 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (192 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type 6. (620 aa)
	SFRP2	Secreted frizzled-related protein 2. (294 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (484 aa)
	PTPRJ	Peptidylprolyl isomerase. (1262 aa)
	SORL1	Sortilin-related receptor. (2205 aa)
	BMP2	Bone morphogenetic protein 2. (388 aa)
	PRKCD	Protein kinase C delta. (671 aa)
	PAQR3	Progestin and adipoQ receptor family member 3 isoform X1. (309 aa)
	TMEM130	Transmembrane protein 130. (292 aa)
	SFRP1	Secreted frizzled-related protein 1 isoform X2. (307 aa)
	SPRY4	Protein sprouty homolog 4. (321 aa)
	SH2B3	SH2B adapter protein 3 isoform X2. (558 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	CAV1	ENSTTRP00000015964	ENSTTRP00000008073	Adiponectin.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.485
ADIPOQ	PAQR3	ENSTTRP00000015964	ENSTTRP00000002029	Adiponectin.	Progestin and adipoQ receptor family member 3 isoform X1.	0.725
APOE	SORL1	ENSTTRP00000008256	ENSTTRP00000002612	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Sortilin-related receptor.	0.763
BMP2	BMP4	ENSTTRP00000002383	ENSTTRP00000008787	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.899
BMP2	BMP7	ENSTTRP00000002383	ENSTTRP00000014836	Bone morphogenetic protein 2.	Bone morphogenetic protein 7 isoform X2.	0.719
BMP4	BMP2	ENSTTRP00000008787	ENSTTRP00000002383	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.899
BMP4	BMP7	ENSTTRP00000008787	ENSTTRP00000014836	Bone morphogenetic protein 4.	Bone morphogenetic protein 7 isoform X2.	0.863
BMP4	SPRY2	ENSTTRP00000008787	ENSTTRP00000011048	Bone morphogenetic protein 4.	Protein sprouty homolog 2.	0.491
BMP7	BMP2	ENSTTRP00000014836	ENSTTRP00000002383	Bone morphogenetic protein 7 isoform X2.	Bone morphogenetic protein 2.	0.719
BMP7	BMP4	ENSTTRP00000014836	ENSTTRP00000008787	Bone morphogenetic protein 7 isoform X2.	Bone morphogenetic protein 4.	0.863
CAV1	ADIPOQ	ENSTTRP00000008073	ENSTTRP00000015964	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Adiponectin.	0.485
CAV1	CAV3	ENSTTRP00000008073	ENSTTRP00000005705	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.951
CAV1	LYN	ENSTTRP00000008073	ENSTTRP00000015970	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Tyrosine-protein kinase.	0.582
CAV3	CAV1	ENSTTRP00000005705	ENSTTRP00000008073	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.951
CAV3	LYN	ENSTTRP00000005705	ENSTTRP00000015970	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Tyrosine-protein kinase.	0.521
CBLC	LYN	ENSTTRP00000007515	ENSTTRP00000015970	E3 ubiquitin-protein ligase CBL-C isoform X1.	Tyrosine-protein kinase.	0.613
CBLC	PTPN6	ENSTTRP00000007515	ENSTTRP00000004527	E3 ubiquitin-protein ligase CBL-C isoform X1.	Tyrosine-protein phosphatase non-receptor type 6.	0.498
CBLC	SH2B3	ENSTTRP00000007515	ENSTTRP00000000894	E3 ubiquitin-protein ligase CBL-C isoform X1.	SH2B adapter protein 3 isoform X2.	0.513
CBLC	SPRY1	ENSTTRP00000007515	ENSTTRP00000014417	E3 ubiquitin-protein ligase CBL-C isoform X1.	Protein sprouty homolog 1.	0.631
CBLC	SPRY2	ENSTTRP00000007515	ENSTTRP00000011048	E3 ubiquitin-protein ligase CBL-C isoform X1.	Protein sprouty homolog 2.	0.675