STRINGSTRING
TMEM79 TMEM79 CERS3 CERS3 FA2H FA2H ARRDC3 ARRDC3 FRAS1 FRAS1 IRF6 IRF6 NSDHL NSDHL EDA EDA HDAC1 HDAC1 SNAI1 SNAI1 RELA RELA ACER1 ACER1 PAX6 PAX6 ACVR1B ACVR1B KRT80 KRT80 KRT7 KRT7 LOC101324147 LOC101324147 LOC101323852 LOC101323852 KRT85 KRT85 KRT84 KRT84 LOC109552089 LOC109552089 KRT75 KRT75 ENSTTRP00000002651 ENSTTRP00000002651 LOC101321922 LOC101321922 LOC101322971 LOC101322971 KRT5 KRT5 PLA2G10 PLA2G10 PPP3CA PPP3CA KRT12 KRT12 ALX4 ALX4 PTCH2 PTCH2 SCEL SCEL INHBA INHBA COL1A2 COL1A2 TFAP2B TFAP2B FOXN1 FOXN1 CELSR1 CELSR1 HOXC13 HOXC13 PUM2 PUM2 STARD7 STARD7 ENSTTRP00000004744 ENSTTRP00000004744 BCL2 BCL2 WNT5A WNT5A ITGA3 ITGA3 TBC1D31 TBC1D31 IFT74 IFT74 COL1A1 COL1A1 FUZ FUZ SOX9 SOX9 ZMPSTE24 ZMPSTE24 FZD3 FZD3 CYP26B1 CYP26B1 LATS1 LATS1 EXPH5 EXPH5 CTNNB1 CTNNB1 WDR48 WDR48 PALLD PALLD SHARPIN SHARPIN ENSTTRP00000006141 ENSTTRP00000006141 CDSN CDSN MET MET JUP JUP PIAS4 PIAS4 SRF SRF SLC2A10 SLC2A10 LGR5 LGR5 EDAR EDAR NOTCH1 NOTCH1 STK4 STK4 KEL KEL NGFR NGFR ZDHHC21 ZDHHC21 DNASE1L2 DNASE1L2 ERCC2 ERCC2 SUFU SUFU SMO SMO MED1 MED1 TGM1 TGM1 ALOX12 ALOX12 FGF7 FGF7 GORAB GORAB BCR BCR COL5A1 COL5A1 LOC101318787 LOC101318787 PSEN1 PSEN1 LSR LSR CLIC4 CLIC4 SAV1 SAV1 NOM1 NOM1 ENSTTRP00000009296 ENSTTRP00000009296 SOSTDC1 SOSTDC1 LATS2 LATS2 WNT10A WNT10A ABCB6 ABCB6 ANXA1 ANXA1 MAP2K1 MAP2K1 APCDD1 APCDD1 FGF10 FGF10 COL3A1 COL3A1 COL5A2 COL5A2 PLEC PLEC ST14 ST14 COMP COMP IL18 IL18 TGM3 TGM3 PNPLA1 PNPLA1 ELOVL1 ELOVL1 LHX2 LHX2 LAMA5 LAMA5 CLDN1 CLDN1 ADAMTS2 ADAMTS2 TP63 TP63 ITGA6 ITGA6 YAP1 YAP1 OPN3 OPN3 SMAD4 SMAD4 MAFB MAFB BCL11B BCL11B FST FST FOSL2 FOSL2 NSUN2 NSUN2 KRT4 KRT4 KRT78 KRT78 KRT8 KRT8 INTU INTU ASH1L ASH1L GATA6 GATA6 SLITRK5 SLITRK5 LGR4 LGR4 TGFB2 TGFB2 LDB2 LDB2 AP3B1 AP3B1 SHH SHH TSG101 TSG101 CNFN CNFN DLL1 DLL1 LTB LTB LRP4 LRP4 TRPC4AP TRPC4AP SOS1 SOS1 ADAM9 ADAM9 UGCG UGCG CD109 CD109 EXT1 EXT1 TRAF3IP2 TRAF3IP2 DHCR24 DHCR24 ENSTTRP00000014183 ENSTTRP00000014183 NF1 NF1 PKD1 PKD1 ERRFI1 ERRFI1 FZD6 FZD6 ITGB4 ITGB4 GNAS GNAS CDH3 CDH3 GRHL3 GRHL3 WNT16 WNT16 SLC27A4 SLC27A4 SFN SFN KDF1 KDF1 DSP DSP OVOL1 OVOL1 TXNIP TXNIP KRT17 KRT17 KRT16 KRT16 KAZN KAZN GRHL1 GRHL1 EZH2 EZH2 EPHA2 EPHA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TMEM79Transmembrane protein 79. (395 aa)
CERS3Ceramide synthase 3. (399 aa)
FA2HFatty acid 2-hydroxylase; Belongs to the cytochrome b5 family. (372 aa)
ARRDC3Arrestin domain-containing protein 3 isoform X1. (414 aa)
FRAS1Extracellular matrix protein FRAS1. (3980 aa)
IRF6Interferon regulatory factor 6 isoform X2. (467 aa)
NSDHLSterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; Belongs to the 3-beta-HSD family. (371 aa)
EDAectodysplasin-A isoform X1. (391 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
RELARELA proto-oncogene, NF-kB subunit. (574 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa)
PAX6Paired box protein Pax-6. (436 aa)
ACVR1BActivin A receptor type 1B. (504 aa)
KRT80LOW QUALITY PROTEIN: keratin, type II cytoskeletal 80; Belongs to the intermediate filament family. (471 aa)
KRT7Keratin, type II cytoskeletal 7; Belongs to the intermediate filament family. (467 aa)
LOC101324147LOW QUALITY PROTEIN: keratin, type II cuticular Hb6-like; Belongs to the intermediate filament family. (192 aa)
LOC101323852Keratin, type II cuticular Hb1; Belongs to the intermediate filament family. (492 aa)
KRT85Keratin, type II cuticular Hb5-like. (504 aa)
KRT84LOW QUALITY PROTEIN: keratin, type II cuticular Hb4; Belongs to the intermediate filament family. (565 aa)
LOC109552089LOW QUALITY PROTEIN: keratin, type II cuticular Hb2-like; Belongs to the intermediate filament family. (306 aa)
KRT75LOW QUALITY PROTEIN: keratin, type II cytoskeletal 75; Belongs to the intermediate filament family. (465 aa)
ENSTTRP00000002651annotation not available (497 aa)
LOC101321922Keratin, type II cytoskeletal 6A-like; Belongs to the intermediate filament family. (559 aa)
LOC101322971LOW QUALITY PROTEIN: keratin, type II cytoskeletal 6A-like; Belongs to the intermediate filament family. (486 aa)
KRT5Keratin, type II cytoskeletal 5; Belongs to the intermediate filament family. (541 aa)
PLA2G10Phospholipase A(2). (128 aa)
PPP3CASerine/threonine-protein phosphatase. (560 aa)
KRT12Keratin, type I cytoskeletal 12 isoform X1; Belongs to the intermediate filament family. (490 aa)
ALX4Homeobox protein aristaless-like 4. (411 aa)
PTCH2Patched 2. (1205 aa)
SCELSciellin isoform X1. (665 aa)
INHBAInhibin beta A chain. (421 aa)
COL1A2Collagen alpha-2(I) chain isoform X1. (1360 aa)
TFAP2BTranscription factor AP-2-beta isoform X4. (360 aa)
FOXN1Forkhead box protein N1 isoform X1. (645 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (3004 aa)
HOXC13Homeobox protein Hox-C13. (335 aa)
PUM2Pumilio homolog 2 isoform X1. (1063 aa)
STARD7stAR-related lipid transfer protein 7, mitochondrial. (311 aa)
ENSTTRP00000004744annotation not available (93 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (470 aa)
ITGA3Integrin subunit alpha 3. (1068 aa)
TBC1D31TBC1 domain family member 31 isoform X1. (1056 aa)
IFT74Intraflagellar transport protein 74 homolog isoform X1. (598 aa)
COL1A1Collagen type I alpha 1 chain. (1462 aa)
FUZFuzzy planar cell polarity protein. (419 aa)
SOX9Transcription factor SOX-9. (509 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
FZD3Frizzled-3 isoform X2; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1. (511 aa)
LATS1Serine/threonine-protein kinase LATS1. (958 aa)
EXPH5Exophilin-5 isoform X1. (1982 aa)
CTNNB1Catenin beta-1. (781 aa)
WDR48WD repeat-containing protein 48 isoform X2. (677 aa)
PALLDPalladin, cytoskeletal associated protein. (1101 aa)
SHARPINSharpin. (333 aa)
ENSTTRP00000006141annotation not available (161 aa)
CDSNCorneodesmosin. (484 aa)
METHepatocyte growth factor receptor isoform X1. (1403 aa)
JUPJunction plakoglobin-like. (744 aa)
PIAS4Protein inhibitor of activated STAT 4. (461 aa)
SRFSerum response factor isoform X2. (509 aa)
SLC2A10Solute carrier family 2, facilitated glucose transporter member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (513 aa)
LGR5Leucine-rich repeat-containing G-protein coupled receptor 5 isoform X1. (890 aa)
EDARTumor necrosis factor receptor superfamily member EDAR. (473 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2527 aa)
STK4Serine/threonine-protein kinase 4 isoform X1. (435 aa)
KELKell blood group glycoprotein. (730 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (427 aa)
ZDHHC21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
DNASE1L2Deoxyribonuclease; Belongs to the DNase I family. (296 aa)
ERCC2TFIIH basal transcription factor complex helicase XPD subunit. (772 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (423 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1512 aa)
TGM1Protein-glutamine gamma-glutamyltransferase K. (824 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S-type isoform X1. (663 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
GORABLOW QUALITY PROTEIN: RAB6-interacting golgin. (395 aa)
BCRBCR activator of RhoGEF and GTPase. (1260 aa)
COL5A1Collagen alpha-1(V) chain-like. (1839 aa)
LOC101318787Golgi pH regulator isoform X1. (455 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (466 aa)
LSRLipolysis stimulated lipoprotein receptor. (558 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
SAV1Protein salvador homolog 1. (385 aa)
NOM1Nucleolar MIF4G domain-containing protein 1 isoform X1. (841 aa)
ENSTTRP00000009296annotation not available (181 aa)
SOSTDC1Sclerostin domain-containing protein 1. (229 aa)
LATS2Large tumor suppressor kinase 2. (992 aa)
WNT10AWnt family member 10A. (417 aa)
ABCB6ATP binding cassette subfamily B member 6 (Langereis blood group). (844 aa)
ANXA1Annexin. (328 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (393 aa)
APCDD1Protein APCDD1 isoform X2. (512 aa)
FGF10Fibroblast growth factor 10. (142 aa)
COL3A1Collagen alpha-1(III) chain. (1464 aa)
COL5A2Collagen alpha-2(V) chain isoform X1. (1448 aa)
PLECPlectin. (4664 aa)
ST14Suppression of tumorigenicity 14. (627 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa)
TGM3Protein-glutamine gamma-glutamyltransferase E. (694 aa)
PNPLA1Patatin-like phospholipase domain-containing protein 1 isoform X2. (476 aa)
ELOVL1ELOVL fatty acid elongase 1. (279 aa)
LHX2LIM/homeobox protein Lhx2. (397 aa)
LAMA5Laminin subunit alpha-5-like. (3506 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
ADAMTS2A disintegrin and metalloproteinase with thrombospondin motifs 2. (1161 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
ITGA6Integrin alpha-6 isoform X1; Belongs to the integrin alpha chain family. (1130 aa)
YAP1Transcriptional coactivator YAP1 isoform X4. (488 aa)
OPN3Opsin 3. (392 aa)
SMAD4Mothers against decapentaplegic homolog. (407 aa)
MAFBTranscription factor MafB. (323 aa)
BCL11BB-cell lymphoma/leukemia 11B. (897 aa)
FSTFollistatin isoform X2. (343 aa)
FOSL2Fos-related antigen 2 isoform X5. (326 aa)
NSUN2tRNA (Cytosine(34)-C(5))-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (760 aa)
KRT4Keratin 4. (590 aa)
KRT78Keratin, type II cytoskeletal 78; Belongs to the intermediate filament family. (515 aa)
KRT8LOW QUALITY PROTEIN: keratin, type II cytoskeletal 8-like; Belongs to the intermediate filament family. (483 aa)
INTUProtein inturned. (931 aa)
ASH1LHistone-lysine N-methyltransferase ASH1L isoform X1. (2967 aa)
GATA6Transcription factor GATA-6. (592 aa)
SLITRK5SLIT and NTRK-like protein 5. (908 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1. (908 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (416 aa)
LDB2LIM domain-binding protein 2 isoform X1. (373 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1092 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (449 aa)
TSG101Tumor susceptibility 101. (391 aa)
CNFNCornifelin. (110 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (784 aa)
LTBLymphotoxin beta. (193 aa)
LRP4Low-density lipoprotein receptor-related protein 4. (1924 aa)
TRPC4APShort transient receptor potential channel 4-associated protein. (780 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1304 aa)
ADAM9Disintegrin and metalloproteinase domain-containing protein 9 isoform X1. (819 aa)
UGCGCeramide glucosyltransferase. (394 aa)
CD109CD109 antigen isoform X1. (1440 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (746 aa)
TRAF3IP2Adapter protein CIKS isoform X1. (572 aa)
DHCR24Delta(24)-sterol reductase isoform X1. (516 aa)
ENSTTRP00000014183annotation not available (197 aa)
NF1Neurofibromin. (2814 aa)
PKD1Polycystin-1 isoform X3. (4289 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (459 aa)
FZD6Frizzled-6 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (707 aa)
ITGB4Integrin beta-4. (1815 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas. (969 aa)
CDH3Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. (830 aa)
GRHL3Grainyhead-like protein 3 homolog. (605 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
SLC27A4Long-chain fatty acid transport protein 4-like. (642 aa)
SFNStratifin. (248 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
DSPDesmoplakin isoform X1. (2806 aa)
OVOL1Ovo like transcriptional repressor 1. (267 aa)
TXNIPThioredoxin-interacting protein. (389 aa)
KRT17Keratin, type I cytoskeletal 17; Belongs to the intermediate filament family. (420 aa)
KRT16Keratin 16. (420 aa)
KAZNKazrin. (695 aa)
GRHL1Grainyhead-like protein 1 homolog isoform X2. (618 aa)
EZH2Histone-lysine N-methyltransferase EZH2 isoform X2. (751 aa)
EPHA2Ephrin type-A receptor 2-like. (974 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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