STRINGSTRING
TBX3 TBX3 SOX6 SOX6 NODAL NODAL GAP43 GAP43 FOXA1 FOXA1 RTF1 RTF1 SLAMF6 SLAMF6 FEZF2 FEZF2 BMP2 BMP2 MGA MGA BRAF BRAF EDNRA EDNRA KDR KDR PAX6 PAX6 TCF7L2 TCF7L2 ETV2 ETV2 IRF4 IRF4 EPOP EPOP APC APC HES1 HES1 JAG2 JAG2 MTOR MTOR NTF4 NTF4 SIX2 SIX2 SFRP1 SFRP1 GATA2 GATA2 TBX5 TBX5 IL7 IL7 PRADC1 PRADC1 ENSTTRP00000000710 ENSTTRP00000000710 DBX1 DBX1 PML PML WNT16 WNT16 ASCL1 ASCL1 LEO1 LEO1 SMAD5 SMAD5 HEY2 HEY2 KIAA1549L KIAA1549L WNT7B WNT7B TBXT TBXT NEUROD1 NEUROD1 PTF1A PTF1A PITX1 PITX1 RARA RARA WNT5B WNT5B RHOA RHOA EBF2 EBF2 TBX20 TBX20 TM2D3 TM2D3 CTSL CTSL NEUROD4 NEUROD4 ENSTTRP00000014726 ENSTTRP00000014726 GCM1 GCM1 FGF8 FGF8 MYL2 MYL2 LBX1 LBX1 EXT1 EXT1 APC2 APC2 DMRT3 DMRT3 EHMT2 EHMT2 RAG2 RAG2 TBX22 TBX22 IL6R IL6R DLL1 DLL1 DOCK7 DOCK7 MYOD1 MYOD1 SIX1 SIX1 SHH SHH TGFBR1 TGFBR1 ONECUT1 ONECUT1 TBX19 TBX19 GATA6 GATA6 ARHGEF2 ARHGEF2 WNT11 WNT11 STAT6 STAT6 SOX5 SOX5 PRDM14 PRDM14 ONECUT2 ONECUT2 PRDM1 PRDM1 ISL2 ISL2 TGFB1I1 TGFB1I1 EYA1 EYA1 BARHL2 BARHL2 CTR9 CTR9 CDON CDON BCL11B BCL11B GATA4 GATA4 EPAS1 EPAS1 SMAD4 SMAD4 TAL1 TAL1 SPRY2 SPRY2 GSX2 GSX2 DLL4 DLL4 DLX2 DLX2 DLX1 DLX1 VWA5B2 VWA5B2 ENSTTRP00000010661 ENSTTRP00000010661 WNT7A WNT7A GATA5 GATA5 TBX15 TBX15 PTCH1 PTCH1 ISL1 ISL1 EOMES EOMES FGF10 FGF10 KDM6B KDM6B ERBB4 ERBB4 IHH IHH FEV FEV WNT10A WNT10A WNT6 WNT6 WNT2B WNT2B ITGB1 ITGB1 LATS2 LATS2 SOSTDC1 SOSTDC1 ENSTTRP00000009296 ENSTTRP00000009296 WNT8A WNT8A NKX2-1 NKX2-1 TEAD3 TEAD3 BATF BATF PSEN1 PSEN1 BMP4 BMP4 NKX2-2 NKX2-2 IL6 IL6 NR2E1 NR2E1 SOX13 SOX13 ID2 ID2 MYT1L MYT1L SOX12 SOX12 SMO SMO SUFU SUFU TLX3 TLX3 SMAD1 SMAD1 GSC GSC CTSV CTSV SPDEF SPDEF TEAD4 TEAD4 DLX6 DLX6 NOTCH1 NOTCH1 LHX3 LHX3 STAT3 STAT3 MITF MITF RUNX2 RUNX2 HOXA2 HOXA2 ENSTTRP00000006381 ENSTTRP00000006381 WNT9A WNT9A TBR1 TBR1 PRRX1 PRRX1 FOXN4 FOXN4 VWA5B1 VWA5B1 CTNNB1 CTNNB1 EDN1 EDN1 KIAA1549 KIAA1549 LATS1 LATS1 CYP26B1 CYP26B1 MYL10 MYL10 SOX8 SOX8 TBX18 TBX18 WNT4 WNT4 GSX1 GSX1 SOX9 SOX9 TBX6 TBX6 ZNF521 ZNF521 WNT5A WNT5A TENM4 TENM4 BCL2 BCL2 GATA3 GATA3 POU4F1 POU4F1 DHH DHH TBX21 TBX21 WNT1 WNT1 WNT10B WNT10B GATA1 GATA1 TBX4 TBX4 SFRP2 SFRP2 TBX2 TBX2 HOXC10 HOXC10 WNT8B WNT8B FOXN1 FOXN1 MEF2C MEF2C TBX10 TBX10 TOX TOX WNT9B WNT9B WNT3 WNT3 GLI3 GLI3 NKX6-3 NKX6-3 PAF1 PAF1 HOXA11 HOXA11 PROX1 PROX1 PTCH2 PTCH2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TBX3T-box transcription factor TBX3. (742 aa)
SOX6Transcription factor SOX-6. (828 aa)
NODALNodal homolog. (348 aa)
GAP43Neuromodulin. (268 aa)
FOXA1Hepatocyte nuclear factor 3-alpha. (442 aa)
RTF1RNA polymerase-associated protein RTF1 homolog. (710 aa)
SLAMF6SLAM family member 6. (330 aa)
FEZF2Fez family zinc finger protein 2. (457 aa)
BMP2Bone morphogenetic protein 2. (388 aa)
MGAMAX gene-associated protein isoform X2. (3025 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X4. (757 aa)
EDNRAEndothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
KDRVascular endothelial growth factor receptor 2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1307 aa)
PAX6Paired box protein Pax-6. (436 aa)
TCF7L2Transcription factor 7-like 2 isoform X5. (639 aa)
ETV2ETS translocation variant 2. (362 aa)
IRF4Interferon regulatory factor 4 isoform X1. (451 aa)
EPOPUncharacterized protein C17orf96 homolog. (379 aa)
APCAdenomatous polyposis coli protein isoform X2. (2845 aa)
HES1Transcription factor HES-1. (280 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1158 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2442 aa)
NTF4Neurotrophin 4. (210 aa)
SIX2Homeobox protein SIX2. (168 aa)
SFRP1Secreted frizzled-related protein 1 isoform X2. (307 aa)
GATA2GATA binding protein 2. (392 aa)
TBX5T-box transcription factor TBX5. (519 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (176 aa)
PRADC1Protease associated domain containing 1. (183 aa)
ENSTTRP00000000710annotation not available (306 aa)
DBX1Homeobox protein DBX1. (379 aa)
PMLProtein PML isoform X2. (871 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
ASCL1Achaete-scute homolog 1. (172 aa)
LEO1RNA polymerase-associated protein LEO1 isoform X1. (666 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2. (336 aa)
KIAA1549LLOW QUALITY PROTEIN: UPF0606 protein KIAA1549L homolog. (1843 aa)
WNT7BWnt family member 7B. (350 aa)
TBXTBrachyury protein isoform X1. (435 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
PTF1APancreas transcription factor 1 subunit alpha. (326 aa)
PITX1Homeobox protein. (314 aa)
RARARetinoic acid receptor alpha-like. (618 aa)
WNT5BWnt family member 5B. (361 aa)
RHOATransforming protein RhoA. (193 aa)
EBF2Transcription factor COE2. (574 aa)
TBX20T-box transcription factor TBX20. (449 aa)
TM2D3TM2 domain-containing protein 3 isoform X2. (246 aa)
CTSLCathepsin L1 isoform X2; Belongs to the peptidase C1 family. (332 aa)
NEUROD4Neurogenic differentiation factor. (304 aa)
ENSTTRP00000014726annotation not available (263 aa)
GCM1Chorion-specific transcription factor GCMa. (434 aa)
FGF8Fibroblast growth factor 8; Belongs to the heparin-binding growth factors family. (221 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (166 aa)
LBX1Transcription factor LBX1. (281 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (746 aa)
APC2Adenomatous polyposis coli protein 2-like. (2262 aa)
DMRT3Doublesex- and mab-3-related transcription factor 3. (320 aa)
EHMT2Histone-lysine N-methyltransferase EHMT2. (1017 aa)
RAG2V(D)J recombination-activating protein 2. (527 aa)
TBX22T-box transcription factor TBX22. (522 aa)
IL6RInterleukin-6 receptor subunit alpha isoform X2. (466 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (784 aa)
DOCK7Dedicator of cytokinesis protein 7 isoform X2; Belongs to the DOCK family. (2091 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
SIX1Homeobox protein SIX1. (284 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (449 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (458 aa)
ONECUT1One cut homeobox 1. (465 aa)
TBX19T-box transcription factor TBX19. (446 aa)
GATA6Transcription factor GATA-6. (592 aa)
ARHGEF2Rho guanine nucleotide exchange factor 2. (987 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (296 aa)
STAT6Signal transducer and activator of transcription 6. (847 aa)
SOX5Transcription factor SOX-5 isoform X2. (742 aa)
PRDM14PR domain zinc finger protein 14. (570 aa)
ONECUT2One cut domain family member 2. (419 aa)
PRDM1PR domain zinc finger protein 1 isoform X1. (787 aa)
ISL2Insulin gene enhancer protein ISL-2. (324 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein. (456 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (589 aa)
BARHL2barH-like 2 homeobox protein. (380 aa)
CTR9RNA polymerase-associated protein CTR9 homolog isoform X2. (1173 aa)
CDONCell adhesion molecule-related/down-regulated by oncogenes. (1273 aa)
BCL11BB-cell lymphoma/leukemia 11B. (897 aa)
GATA4Transcription factor GATA-4 isoform X2. (442 aa)
EPAS1Endothelial PAS domain protein 1. (870 aa)
SMAD4Mothers against decapentaplegic homolog. (407 aa)
TAL1T-cell acute lymphocytic leukemia protein 1. (330 aa)
SPRY2Protein sprouty homolog 2. (315 aa)
GSX2GS homeobox 2. (302 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (750 aa)
DLX2Homeobox protein DLX-2. (281 aa)
DLX1Distal-less homeobox 1. (255 aa)
VWA5B2Von Willebrand factor A domain-containing protein 5B2 isoform X2. (1007 aa)
ENSTTRP00000010661annotation not available (123 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
GATA5GATA binding protein 5. (398 aa)
TBX15T-box transcription factor TBX15. (602 aa)
PTCH1Protein patched homolog 1 isoform X1. (1313 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
EOMESEomesodermin homolog isoform X2. (684 aa)
FGF10Fibroblast growth factor 10. (142 aa)
KDM6BDynein heavy chain 2, axonemal. (1642 aa)
ERBB4Receptor protein-tyrosine kinase. (1299 aa)
IHHIndian hedgehog protein. (409 aa)
FEVProtein FEV. (239 aa)
WNT10AWnt family member 10A. (417 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (337 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (786 aa)
LATS2Large tumor suppressor kinase 2. (992 aa)
SOSTDC1Sclerostin domain-containing protein 1. (229 aa)
ENSTTRP00000009296annotation not available (181 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
NKX2-1Homeobox protein Nkx-2.1. (394 aa)
TEAD3Transcriptional enhancer factor TEF-5 isoform X1. (472 aa)
BATFBasic leucine zipper transcriptional factor ATF-like. (125 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (466 aa)
BMP4Bone morphogenetic protein 4. (407 aa)
NKX2-2Homeobox protein Nkx-2.2. (271 aa)
IL6Interleukin-6. (208 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (419 aa)
SOX13SRY-box transcription factor 13. (621 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
MYT1LMyelin transcription factor 1-like protein isoform X1. (1179 aa)
SOX12Transcription factor SOX. (313 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (423 aa)
TLX3T-cell leukemia homeobox protein 3. (291 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
GSCHomeobox protein goosecoid. (256 aa)
CTSVCathepsin L1; Belongs to the peptidase C1 family. (333 aa)
SPDEFSAM pointed domain containing ETS transcription factor. (337 aa)
TEAD4TEA domain transcription factor 4. (431 aa)
DLX6Homeobox protein DLX-6. (232 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2527 aa)
LHX3LIM/homeobox protein Lhx3. (403 aa)
STAT3Signal transducer and activator of transcription. (767 aa)
MITFMicrophthalmia-associated transcription factor isoform X1. (526 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (587 aa)
HOXA2Homeobox protein Hox-A2. (295 aa)
ENSTTRP00000006381annotation not available (382 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
TBR1T-box brain protein 1. (450 aa)
PRRX1Paired mesoderm homeobox protein 1. (164 aa)
FOXN4Forkhead box protein N4. (515 aa)
VWA5B1Von Willebrand factor A domain containing 5B1. (1212 aa)
CTNNB1Catenin beta-1. (781 aa)
EDN1Endothelin-1. (202 aa)
KIAA1549UPF0606 protein KIAA1549 homolog. (1850 aa)
LATS1Serine/threonine-protein kinase LATS1. (958 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1. (511 aa)
MYL10Myosin light chain 10. (117 aa)
SOX8Transcription factor SOX-8. (445 aa)
TBX18T-box transcription factor TBX18. (612 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
GSX1GS homeobox 1. (233 aa)
SOX9Transcription factor SOX-9. (509 aa)
TBX6T-box transcription factor 6. (435 aa)
ZNF521Zinc finger protein 521. (1335 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (470 aa)
TENM4Teneurin-4. (2766 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
POU4F1POU domain protein. (419 aa)
DHHDesert hedgehog protein. (396 aa)
TBX21T-box transcription factor TBX21. (535 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
GATA1Erythroid transcription factor. (383 aa)
TBX4T-box transcription factor TBX4. (489 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
TBX2T-box transcription factor TBX2. (703 aa)
HOXC10Homeobox C10. (342 aa)
WNT8BWnt family member 8B. (353 aa)
FOXN1Forkhead box protein N1 isoform X1. (645 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X1. (472 aa)
TBX10T-box transcription factor 10. (318 aa)
TOXThymocyte selection-associated high mobility group box protein TOX. (516 aa)
WNT9BWnt family member 9B. (330 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
GLI3Transcriptional activator GLI3. (1580 aa)
NKX6-3NK6 homeobox 3. (116 aa)
PAF1PAF1 homolog, Paf1/RNA polymerase II complex component. (526 aa)
HOXA11Homeobox protein Hox-A11. (311 aa)
PROX1Prospero homeobox protein 1. (744 aa)
PTCH2Patched 2. (1205 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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