STRINGSTRING
SULT1E1 SULT1E1 DDIT3 DDIT3 LPL LPL TGFB1 TGFB1 ZADH2 ZADH2 FTO FTO FOXO1 FOXO1 TGFB1I1 TGFB1I1 LRP3 LRP3 PTGS2 PTGS2 VSTM2A VSTM2A WDFY2 WDFY2 SIRT2 SIRT2 ALOX5 ALOX5 LGALS12 LGALS12 TRPV4 TRPV4 YAP1 YAP1 ZBTB7C ZBTB7C WIF1 WIF1 NAPEPLD NAPEPLD MEDAG MEDAG TRIO TRIO ASXL2 ASXL2 E2F1 E2F1 ENPP1 ENPP1 GPS2 GPS2 FNDC3B FNDC3B SAV1 SAV1 SORT1 SORT1 DUSP10 DUSP10 FLCN FLCN JAG1 JAG1 STK3 STK3 DLK2 DLK2 ZFP36L2 ZFP36L2 AAMDC AAMDC ENSTTRP00000006381 ENSTTRP00000006381 CMKLR1 CMKLR1 STK4 STK4 ADIG ADIG RORA RORA JDP2 JDP2 DKKL1 DKKL1 HNRNPU HNRNPU WNT5A WNT5A TRIB3 TRIB3 GATA3 GATA3 HDAC6 HDAC6 GNB3 GNB3 TLCD3B TLCD3B WNT1 WNT1 WNT10B WNT10B MEX3C MEX3C SFRP2 SFRP2 C1QL4 C1QL4 FERMT2 FERMT2 KLF5 KLF5 ZFPM2 ZFPM2 CEBPB CEBPB ZFP36 ZFP36 ZFP36L1 ZFP36L1 WWTR1 WWTR1 CDS1 CDS1 SMAD3 SMAD3 RARRES2 RARRES2 HTR2A HTR2A BMP2 BMP2 FRZB FRZB TRIB2 TRIB2 MMP11 MMP11 PIM1 PIM1 HES1 HES1 ZNF385A ZNF385A LEP LEP ZBTB16 ZBTB16 SFRP1 SFRP1 WISP1 WISP1 TAF8 TAF8 PPARD PPARD AXIN1 AXIN1 SOX13 SOX13 ZC3H12A ZC3H12A FFAR4 FFAR4 ENSTTRP00000007877 ENSTTRP00000007877 ADIRF ADIRF ASXL1 ASXL1 RREB1 RREB1 CCDC85B CCDC85B NR1D1 NR1D1 ADIPOQ ADIPOQ ENSTTRP00000015751 ENSTTRP00000015751 PPARG PPARG LRP5 LRP5 SIRT1 SIRT1 ZBTB7B ZBTB7B CREB1 CREB1 BMP7 BMP7 CREBL2 CREBL2 FNDC5 FNDC5 KALRN KALRN ZFPM1 ZFPM1 ANKRD26 ANKRD26 TPH1 TPH1 SIX1 SIX1 NOCT NOCT SYAP1 SYAP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SULT1E1Sulfotransferase; Belongs to the sulfotransferase 1 family. (274 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (167 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (477 aa)
TGFB1Transforming growth factor beta 1. (338 aa)
ZADH2Prostaglandin reductase 3 isoform X1. (307 aa)
FTOAlpha-ketoglutarate-dependent dioxygenase FTO isoform X1. (505 aa)
FOXO1Forkhead box protein O1. (538 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein. (456 aa)
LRP3Low-density lipoprotein receptor-related protein 3 isoform X1. (750 aa)
PTGS2Prostaglandin G/H synthase 2. (603 aa)
VSTM2AV-set and transmembrane domain-containing protein 2A isoform X2. (298 aa)
WDFY2WD repeat and FYVE domain-containing protein 2 isoform X2. (400 aa)
SIRT2NAD-dependent protein deacetylase sirtuin-2. (379 aa)
ALOX5Arachidonate 5-lipoxygenase isoform X1. (672 aa)
LGALS12Galectin-12. (312 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4-like. (591 aa)
YAP1Transcriptional coactivator YAP1 isoform X4. (488 aa)
ZBTB7CZinc finger and BTB domain-containing protein 7C isoform X2. (554 aa)
WIF1Wnt inhibitory factor 1 isoform X2. (376 aa)
NAPEPLDN-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X2. (393 aa)
MEDAGMesenteric estrogen-dependent adipogenesis protein isoform X1. (210 aa)
TRIOTriple functional domain protein isoform X1. (3046 aa)
ASXL2Putative Polycomb group protein ASXL2 isoform X1. (1426 aa)
E2F1Transcription factor E2F1 isoform X1. (437 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (925 aa)
GPS2G protein pathway suppressor 2. (297 aa)
FNDC3BFibronectin type III domain-containing protein 3B isoform X4. (1203 aa)
SAV1Protein salvador homolog 1. (385 aa)
SORT1Sortilin. (831 aa)
DUSP10Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (480 aa)
FLCNFolliculin isoform X2. (574 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
STK3Serine/threonine-protein kinase 3 isoform X1. (480 aa)
DLK2Delta like non-canonical Notch ligand 2. (383 aa)
ZFP36L2mRNA decay activator protein ZFP36L2. (494 aa)
AAMDCMth938 domain-containing protein. (122 aa)
ENSTTRP00000006381annotation not available (382 aa)
CMKLR1Chemokine-like receptor 1; Belongs to the G-protein coupled receptor 1 family. (367 aa)
STK4Serine/threonine-protein kinase 4 isoform X1. (435 aa)
ADIGAdipogenin. (164 aa)
RORANuclear receptor ROR-alpha isoform X5. (522 aa)
JDP2Jun dimerization protein 2. (163 aa)
DKKL1Dickkopf-like protein 1 isoform X1. (209 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U isoform X1. (818 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (470 aa)
TRIB3Tribbles homolog 3. (357 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
HDAC6Histone deacetylase 6. (1141 aa)
GNB3G protein subunit beta 3. (340 aa)
TLCD3BTLC domain containing 3B. (274 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
MEX3CRNA-binding E3 ubiquitin-protein ligase MEX3C. (656 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
C1QL4Complement C1q like 4. (223 aa)
FERMT2Fermitin family homolog 2. (614 aa)
KLF5Krueppel-like factor 5. (370 aa)
ZFPM2Zinc finger protein ZFPM2. (1148 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
ZFP36ZFP36 ring finger protein. (322 aa)
ZFP36L1mRNA decay activator protein ZFP36L1. (338 aa)
WWTR1WW domain-containing transcription regulator protein 1. (400 aa)
CDS1Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (418 aa)
SMAD3Mothers against decapentaplegic homolog 3. (291 aa)
RARRES2Retinoic acid receptor responder 2. (163 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
BMP2Bone morphogenetic protein 2. (388 aa)
FRZBSecreted frizzled-related protein 3. (325 aa)
TRIB2Tribbles homolog 2. (341 aa)
MMP11Stromelysin-3. (488 aa)
PIM1Serine/threonine-protein kinase pim-1. (255 aa)
HES1Transcription factor HES-1. (280 aa)
ZNF385AZinc finger protein 385A. (338 aa)
LEPLeptin. (167 aa)
ZBTB16Zinc finger and BTB domain-containing protein 16 isoform X1. (673 aa)
SFRP1Secreted frizzled-related protein 1 isoform X2. (307 aa)
WISP1WNT1-inducible-signaling pathway protein 1. (259 aa)
TAF8Transcription initiation factor TFIID subunit 8 isoform X3. (306 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
AXIN1Axin-1 isoform X2. (866 aa)
SOX13SRY-box transcription factor 13. (621 aa)
ZC3H12AEndoribonuclease ZC3H12A. (598 aa)
FFAR4Free fatty acid receptor 4. (377 aa)
ENSTTRP00000007877annotation not available (447 aa)
ADIRFAdipogenesis regulatory factor. (76 aa)
ASXL1Putative Polycomb group protein ASXL1 isoform X1. (1526 aa)
RREB1Ras-responsive element-binding protein 1 isoform X1. (1737 aa)
CCDC85BCoiled-coil domain-containing protein 85B. (202 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
ADIPOQAdiponectin. (242 aa)
ENSTTRP00000015751annotation not available (328 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
LRP5LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 5. (1582 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (616 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (416 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
BMP7Bone morphogenetic protein 7 isoform X2. (431 aa)
CREBL2cAMP-responsive element-binding protein-like 2 isoform X5. (120 aa)
FNDC5Fibronectin type III domain-containing protein 5. (198 aa)
KALRNKalirin isoform X2. (2985 aa)
ZFPM1Zinc finger protein ZFPM1. (984 aa)
ANKRD26Ankyrin repeat domain-containing protein 26-like isoform X2. (1450 aa)
TPH1Tryptophan 5-hydroxylase 1. (465 aa)
SIX1Homeobox protein SIX1. (284 aa)
NOCTNocturnin. (383 aa)
SYAP1Synapse-associated protein 1 isoform X2. (352 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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