(22 nodes) Positive regulation of epidermal cell differentiation network (Tursiops truncatus)

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Your Input:
	ENSTTRP00000007731	annotation not available (287 aa)
	NCOA3	Nuclear receptor coactivator. (1404 aa)
	PTCH2	Patched 2. (1205 aa)
	NUMA1	Nuclear mitotic apparatus protein 1 isoform X1. (2113 aa)
	SFRP4	Secreted frizzled-related protein 4 isoform X1. (285 aa)
	MACROH2A1	Histone H2A; Belongs to the histone H2A family. (372 aa)
	MACROH2A2	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
	NOTCH1	Neurogenic locus notch homolog protein 1. (2527 aa)
	CYP27B1	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial isoform X2; Belongs to the cytochrome P450 family. (508 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1512 aa)
	BMP4	Bone morphogenetic protein 4. (407 aa)
	ENSTTRP00000009296	annotation not available (181 aa)
	ALOX15B	Arachidonate 15-lipoxygenase type B. (675 aa)
	PTCH1	Protein patched homolog 1 isoform X1. (1313 aa)
	ZBED2	Zinc finger BED-type containing 2. (203 aa)
	VDR	Vitamin D3 receptor. (427 aa)
	PRKCH	Protein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (635 aa)
	CYP27C1	Cytochrome P450 27C1 isoform X1. (372 aa)
	ETV4	ETS translocation variant 4. (473 aa)
	SFN	Stratifin. (248 aa)
	KDF1	Keratinocyte differentiation factor 1. (398 aa)
	ENSTTRP00000016553	annotation not available (423 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	ENSTTRP00000007731	ENSTTRP00000008787	ENSTTRP00000007731	Bone morphogenetic protein 4.	annotation not available	0.763
BMP4	NOTCH1	ENSTTRP00000008787	ENSTTRP00000007173	Bone morphogenetic protein 4.	Neurogenic locus notch homolog protein 1.	0.417
BMP4	PTCH1	ENSTTRP00000008787	ENSTTRP00000010338	Bone morphogenetic protein 4.	Protein patched homolog 1 isoform X1.	0.584
CYP27B1	MED1	ENSTTRP00000007906	ENSTTRP00000008003	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial isoform X2; Belongs to the cytochrome P450 family.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.561
CYP27B1	NCOA3	ENSTTRP00000007906	ENSTTRP00000000019	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial isoform X2; Belongs to the cytochrome P450 family.	Nuclear receptor coactivator.	0.467
CYP27B1	VDR	ENSTTRP00000007906	ENSTTRP00000011935	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial isoform X2; Belongs to the cytochrome P450 family.	Vitamin D3 receptor.	0.811
CYP27C1	MED1	ENSTTRP00000013797	ENSTTRP00000008003	Cytochrome P450 27C1 isoform X1.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.561
CYP27C1	NCOA3	ENSTTRP00000013797	ENSTTRP00000000019	Cytochrome P450 27C1 isoform X1.	Nuclear receptor coactivator.	0.467
ENSTTRP00000007731	BMP4	ENSTTRP00000007731	ENSTTRP00000008787	annotation not available	Bone morphogenetic protein 4.	0.763
ENSTTRP00000007731	NOTCH1	ENSTTRP00000007731	ENSTTRP00000007173	annotation not available	Neurogenic locus notch homolog protein 1.	0.507
ETV4	NCOA3	ENSTTRP00000015212	ENSTTRP00000000019	ETS translocation variant 4.	Nuclear receptor coactivator.	0.964
KDF1	SFN	ENSTTRP00000015817	ENSTTRP00000015808	Keratinocyte differentiation factor 1.	Stratifin.	0.502
MED1	CYP27B1	ENSTTRP00000008003	ENSTTRP00000007906	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial isoform X2; Belongs to the cytochrome P450 family.	0.561
MED1	CYP27C1	ENSTTRP00000008003	ENSTTRP00000013797	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Cytochrome P450 27C1 isoform X1.	0.561
MED1	NCOA3	ENSTTRP00000008003	ENSTTRP00000000019	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Nuclear receptor coactivator.	0.925
MED1	VDR	ENSTTRP00000008003	ENSTTRP00000011935	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Vitamin D3 receptor.	0.910
NCOA3	CYP27B1	ENSTTRP00000000019	ENSTTRP00000007906	Nuclear receptor coactivator.	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial isoform X2; Belongs to the cytochrome P450 family.	0.467
NCOA3	CYP27C1	ENSTTRP00000000019	ENSTTRP00000013797	Nuclear receptor coactivator.	Cytochrome P450 27C1 isoform X1.	0.467
NCOA3	ETV4	ENSTTRP00000000019	ENSTTRP00000015212	Nuclear receptor coactivator.	ETS translocation variant 4.	0.964
NCOA3	MED1	ENSTTRP00000000019	ENSTTRP00000008003	Nuclear receptor coactivator.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.925