STRINGSTRING
REST REST MEF2C MEF2C EIF4E EIF4E DDX6 DDX6 LSM1 LSM1 NKX2-5 NKX2-5 FGFR1 FGFR1 SFRP2 SFRP2 DPYSL2 DPYSL2 SOX11 SOX11 BCL2 BCL2 MYCL MYCL TBX6 TBX6 SOX9 SOX9 GDPD5 GDPD5 SOX8 SOX8 JAG1 JAG1 HMG20A HMG20A BRINP3 BRINP3 CNTN2 CNTN2 ENSTTRP00000006381 ENSTTRP00000006381 HOXA2 HOXA2 CDK5RAP2 CDK5RAP2 NEUROD2 NEUROD2 POU4F2 POU4F2 BRINP2 BRINP2 NOTCH1 NOTCH1 DLX6 DLX6 TTC3 TTC3 CNTN4 CNTN4 MMD MMD ENSTTRP00000007731 ENSTTRP00000007731 ALK ALK TLX3 TLX3 MED1 MED1 ID2 ID2 NR2E1 NR2E1 NKX2-2 NKX2-2 BMP4 BMP4 GDF11 GDF11 ENSTTRP00000009296 ENSTTRP00000009296 ZNF536 ZNF536 ITGB1 ITGB1 EIF4ENIF1 EIF4ENIF1 RNF112 RNF112 CUNH16orf52 CUNH16orf52 DIXDC1 DIXDC1 ZFHX2 ZFHX2 ENSTTRP00000010105 ENSTTRP00000010105 NTF3 NTF3 LOC101333926 LOC101333926 ISL1 ISL1 PCP4 PCP4 NGF NGF GPR37L1 GPR37L1 EIF4G1 EIF4G1 DLX1 DLX1 DLX2 DLX2 SIN3A SIN3A ZEB1 ZEB1 MMD2 MMD2 BCL11B BCL11B CDON CDON EYA1 EYA1 FGF20 FGF20 ISL2 ISL2 CTDSP1 CTDSP1 BRINP1 BRINP1 ENSTTRP00000012482 ENSTTRP00000012482 ARHGEF2 ARHGEF2 DUOXA1 DUOXA1 SHH SHH HOXD3 HOXD3 SIX1 SIX1 DLL1 DLL1 HEYL HEYL MEIS2 MEIS2 BIN1 BIN1 MEIS1 MEIS1 IMPACT IMPACT YWHAG YWHAG ECT2 ECT2 NLGN1 NLGN1 LBX1 LBX1 ROCK1 ROCK1 BMP7 BMP7 BMP6 BMP6 DISP3 DISP3 ASCL1 ASCL1 HEY2 HEY2 NEUROD1 NEUROD1 BCL6 BCL6 VWC2 VWC2 RHOA RHOA HEY1 HEY1 CYB5D2 CYB5D2 BEND6 BEND6 SFRP1 SFRP1 NTF4 NTF4 EDNRB EDNRB LRRC45 LRRC45 HES1 HES1 NKX6-1 NKX6-1 MAP3K13 MAP3K13 PAX6 PAX6 LRRK2 LRRK2 NEPRO NEPRO TRIM32 TRIM32 BMP2 BMP2 FEZF2 FEZF2 MIB1 MIB1 SPAG9 SPAG9 LTK LTK FOXA1 FOXA1 ZFHX3 ZFHX3 CASZ1 CASZ1 APP APP SOCS2 SOCS2 PROX1 PROX1 CALR CALR GLI3 GLI3 LMX1A LMX1A ZC4H2 ZC4H2 PHOX2B PHOX2B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RESTRE1-silencing transcription factor. (656 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X1. (472 aa)
EIF4EEukaryotic translation initiation factor 4E isoform X2; Belongs to the eukaryotic initiation factor 4E family. (211 aa)
DDX6Probable ATP-dependent RNA helicase DDX6; Belongs to the DEAD box helicase family. (483 aa)
LSM1U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (133 aa)
NKX2-5Homeobox protein Nkx-2.5. (323 aa)
FGFR1Fibroblast growth factor receptor 1. (822 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
DPYSL2Dihydropyrimidinase-related protein 2. (571 aa)
SOX11Transcription factor SOX. (309 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
MYCLProtein L-Myc. (394 aa)
TBX6T-box transcription factor 6. (435 aa)
SOX9Transcription factor SOX-9. (509 aa)
GDPD5Glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X1. (565 aa)
SOX8Transcription factor SOX-8. (445 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
HMG20AHigh mobility group protein 20A. (346 aa)
BRINP3BMP/retinoic acid-inducible neural-specific protein 3 isoform X1. (761 aa)
CNTN2Contactin 2. (1001 aa)
ENSTTRP00000006381annotation not available (382 aa)
HOXA2Homeobox protein Hox-A2. (295 aa)
CDK5RAP2LOW QUALITY PROTEIN: CDK5 regulatory subunit-associated protein 2. (1890 aa)
NEUROD2Neuronal differentiation 2. (382 aa)
POU4F2POU class 4 homeobox 2. (409 aa)
BRINP2BMP/retinoic acid-inducible neural-specific protein 2. (784 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2527 aa)
DLX6Homeobox protein DLX-6. (232 aa)
TTC3E3 ubiquitin-protein ligase TTC3-like isoform X1. (1934 aa)
CNTN4Contactin-4. (1026 aa)
MMDMonocyte to macrophage differentiation factor isoform X1. (229 aa)
ENSTTRP00000007731annotation not available (287 aa)
ALKALK tyrosine kinase receptor-like. (1614 aa)
TLX3T-cell leukemia homeobox protein 3. (291 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1512 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (419 aa)
NKX2-2Homeobox protein Nkx-2.2. (271 aa)
BMP4Bone morphogenetic protein 4. (407 aa)
GDF11Growth differentiation factor 11. (313 aa)
ENSTTRP00000009296annotation not available (181 aa)
ZNF536Zinc finger protein 536. (1298 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (786 aa)
EIF4ENIF1Eukaryotic translation initiation factor 4E transporter isoform X2. (980 aa)
RNF112Ring finger protein 112. (629 aa)
CUNH16orf52Uncharacterized protein C16orf52 homolog. (78 aa)
DIXDC1Dixin isoform X1. (650 aa)
ZFHX2Zinc finger homeobox 2. (1509 aa)
ENSTTRP00000010105annotation not available (856 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (252 aa)
LOC101333926RE1-silencing transcription factor-like. (974 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
PCP4Purkinje cell protein 4. (62 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
GPR37L1Prosaposin receptor GPR37L1. (462 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1537 aa)
DLX1Distal-less homeobox 1. (255 aa)
DLX2Homeobox protein DLX-2. (281 aa)
SIN3APaired amphipathic helix protein Sin3a isoform X1. (1211 aa)
ZEB1Zinc finger E-box-binding homeobox 1 isoform X1. (1120 aa)
MMD2LOW QUALITY PROTEIN: monocyte to macrophage differentiation factor 2. (266 aa)
BCL11BB-cell lymphoma/leukemia 11B. (897 aa)
CDONCell adhesion molecule-related/down-regulated by oncogenes. (1273 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (589 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
ISL2Insulin gene enhancer protein ISL-2. (324 aa)
CTDSP1Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1. (261 aa)
BRINP1BMP/retinoic acid-inducible neural-specific protein 1. (761 aa)
ENSTTRP00000012482annotation not available (255 aa)
ARHGEF2Rho guanine nucleotide exchange factor 2. (987 aa)
DUOXA1Dual oxidase maturation factor 1. (443 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (449 aa)
HOXD3Homeobox protein Hox-D3. (432 aa)
SIX1Homeobox protein SIX1. (284 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (784 aa)
HEYLHairy/enhancer-of-split related with YRPW motif-like protein. (323 aa)
MEIS2Homeobox protein Meis2 isoform X1. (345 aa)
BIN1Myc box-dependent-interacting protein 1. (594 aa)
MEIS1Homeobox protein Meis1 isoform X2. (463 aa)
IMPACTProtein IMPACT isoform X3. (319 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma. (238 aa)
ECT2Protein ECT2 isoform X5. (914 aa)
NLGN1Neuroligin-1 isoform X3. (832 aa)
LBX1Transcription factor LBX1. (281 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1353 aa)
BMP7Bone morphogenetic protein 7 isoform X2. (431 aa)
BMP6Bone morphogenetic protein 6. (304 aa)
DISP3Dispatched RND transporter family member 3. (1437 aa)
ASCL1Achaete-scute homolog 1. (172 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2. (336 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
BCL6B-cell lymphoma 6 protein. (699 aa)
VWC2Brorin isoform X1. (199 aa)
RHOATransforming protein RhoA. (193 aa)
HEY1Hairy/enhancer-of-split related with YRPW motif protein 1 isoform X1. (193 aa)
CYB5D2Neuferricin; Belongs to the cytochrome b5 family. (264 aa)
BEND6BEN domain-containing protein 6. (279 aa)
SFRP1Secreted frizzled-related protein 1 isoform X2. (307 aa)
NTF4Neurotrophin 4. (210 aa)
EDNRBEndothelin B receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (530 aa)
LRRC45Leucine rich repeat containing 45. (670 aa)
HES1Transcription factor HES-1. (280 aa)
NKX6-1Homeobox protein Nkx-6.1. (364 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (964 aa)
PAX6Paired box protein Pax-6. (436 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2. (2526 aa)
NEPRONucleolus and neural progenitor protein isoform X1. (563 aa)
TRIM32E3 ubiquitin-protein ligase TRIM32. (653 aa)
BMP2Bone morphogenetic protein 2. (388 aa)
FEZF2Fez family zinc finger protein 2. (457 aa)
MIB1E3 ubiquitin-protein ligase MIB1. (1006 aa)
SPAG9C-Jun-amino-terminal kinase-interacting protein 4 isoform X2. (1316 aa)
LTKLOW QUALITY PROTEIN: leukocyte tyrosine kinase receptor. (829 aa)
FOXA1Hepatocyte nuclear factor 3-alpha. (442 aa)
ZFHX3Zinc finger homeobox protein 3-like. (3666 aa)
CASZ1Castor zinc finger 1. (1628 aa)
APPAmyloid beta A4 protein isoform X1. (763 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
PROX1Prospero homeobox protein 1. (744 aa)
CALRCalreticulin. (417 aa)
GLI3Transcriptional activator GLI3. (1580 aa)
LMX1ALIM homeobox transcription factor 1-alpha. (382 aa)
ZC4H2Zinc finger C4H2 domain-containing protein isoform X1. (224 aa)
PHOX2BPaired mesoderm homeobox protein 2B. (234 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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