(50 nodes) Positive regulation of neuron differentiation network (Tursiops truncatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HOXD3	Homeobox protein Hox-D3. (432 aa)
	HEYL	Hairy/enhancer-of-split related with YRPW motif-like protein. (323 aa)
	IMPACT	Protein IMPACT isoform X3. (319 aa)
	ECT2	Protein ECT2 isoform X5. (914 aa)
	BMP7	Bone morphogenetic protein 7 isoform X2. (431 aa)
	BMP6	Bone morphogenetic protein 6. (304 aa)
	NEUROD1	Neurogenic differentiation factor. (356 aa)
	BCL6	B-cell lymphoma 6 protein. (699 aa)
	VWC2	Brorin isoform X1. (199 aa)
	RHOA	Transforming protein RhoA. (193 aa)
	ENSTTRP00000007731	annotation not available (287 aa)
	CYB5D2	Neuferricin; Belongs to the cytochrome b5 family. (264 aa)
	BEND6	BEN domain-containing protein 6. (279 aa)
	NKX6-1	Homeobox protein Nkx-6.1. (364 aa)
	TRIM32	E3 ubiquitin-protein ligase TRIM32. (653 aa)
	BMP2	Bone morphogenetic protein 2. (388 aa)
	FEZF2	Fez family zinc finger protein 2. (457 aa)
	SPAG9	C-Jun-amino-terminal kinase-interacting protein 4 isoform X2. (1316 aa)
	FOXA1	Hepatocyte nuclear factor 3-alpha. (442 aa)
	SOCS2	Suppressor of cytokine signaling 2. (198 aa)
	PROX1	Prospero homeobox protein 1. (744 aa)
	ZC4H2	Zinc finger C4H2 domain-containing protein isoform X1. (224 aa)
	REST	RE1-silencing transcription factor. (656 aa)
	PHOX2B	Paired mesoderm homeobox protein 2B. (234 aa)
	MEF2C	Myocyte-specific enhancer factor 2C isoform X1. (472 aa)
	NKX2-5	Homeobox protein Nkx-2.5. (323 aa)
	FGFR1	Fibroblast growth factor receptor 1. (822 aa)
	SOX11	Transcription factor SOX. (309 aa)
	GDPD5	Glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X1. (565 aa)
	BRINP3	BMP/retinoic acid-inducible neural-specific protein 3 isoform X1. (761 aa)
	NEUROD2	Neuronal differentiation 2. (382 aa)
	BRINP2	BMP/retinoic acid-inducible neural-specific protein 2. (784 aa)
	DLX6	Homeobox protein DLX-6. (232 aa)
	MMD	Monocyte to macrophage differentiation factor isoform X1. (229 aa)
	NKX2-2	Homeobox protein Nkx-2.2. (271 aa)
	BMP4	Bone morphogenetic protein 4. (407 aa)
	RNF112	Ring finger protein 112. (629 aa)
	LOC101333926	RE1-silencing transcription factor-like. (974 aa)
	PCP4	Purkinje cell protein 4. (62 aa)
	EIF4G1	Eukaryotic translation initiation factor 4 gamma 1. (1537 aa)
	DLX1	Distal-less homeobox 1. (255 aa)
	DLX2	Homeobox protein DLX-2. (281 aa)
	SIN3A	Paired amphipathic helix protein Sin3a isoform X1. (1211 aa)
	ZEB1	Zinc finger E-box-binding homeobox 1 isoform X1. (1120 aa)
	MMD2	LOW QUALITY PROTEIN: monocyte to macrophage differentiation factor 2. (266 aa)
	CDON	Cell adhesion molecule-related/down-regulated by oncogenes. (1273 aa)
	BRINP1	BMP/retinoic acid-inducible neural-specific protein 1. (761 aa)
	ENSTTRP00000012482	annotation not available (255 aa)
	ARHGEF2	Rho guanine nucleotide exchange factor 2. (987 aa)
	DUOXA1	Dual oxidase maturation factor 1. (443 aa)

Your Current Organism:

Tursiops truncatus

NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF2	RHOA	ENSTTRP00000012656	ENSTTRP00000016460	Rho guanine nucleotide exchange factor 2.	Transforming protein RhoA.	0.972
BCL6	SIN3A	ENSTTRP00000016333	ENSTTRP00000010863	B-cell lymphoma 6 protein.	Paired amphipathic helix protein Sin3a isoform X1.	0.641
BMP2	BMP4	ENSTTRP00000002383	ENSTTRP00000008787	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.899
BMP2	BMP6	ENSTTRP00000002383	ENSTTRP00000015103	Bone morphogenetic protein 2.	Bone morphogenetic protein 6.	0.938
BMP2	BMP7	ENSTTRP00000002383	ENSTTRP00000014836	Bone morphogenetic protein 2.	Bone morphogenetic protein 7 isoform X2.	0.719
BMP2	ENSTTRP00000007731	ENSTTRP00000002383	ENSTTRP00000007731	Bone morphogenetic protein 2.	annotation not available	0.730
BMP4	BMP2	ENSTTRP00000008787	ENSTTRP00000002383	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.899
BMP4	BMP6	ENSTTRP00000008787	ENSTTRP00000015103	Bone morphogenetic protein 4.	Bone morphogenetic protein 6.	0.955
BMP4	BMP7	ENSTTRP00000008787	ENSTTRP00000014836	Bone morphogenetic protein 4.	Bone morphogenetic protein 7 isoform X2.	0.863
BMP4	ENSTTRP00000007731	ENSTTRP00000008787	ENSTTRP00000007731	Bone morphogenetic protein 4.	annotation not available	0.763
BMP4	FGFR1	ENSTTRP00000008787	ENSTTRP00000004280	Bone morphogenetic protein 4.	Fibroblast growth factor receptor 1.	0.453
BMP4	MEF2C	ENSTTRP00000008787	ENSTTRP00000003719	Bone morphogenetic protein 4.	Myocyte-specific enhancer factor 2C isoform X1.	0.418
BMP4	NKX2-5	ENSTTRP00000008787	ENSTTRP00000004234	Bone morphogenetic protein 4.	Homeobox protein Nkx-2.5.	0.493
BMP6	BMP2	ENSTTRP00000015103	ENSTTRP00000002383	Bone morphogenetic protein 6.	Bone morphogenetic protein 2.	0.938
BMP6	BMP4	ENSTTRP00000015103	ENSTTRP00000008787	Bone morphogenetic protein 6.	Bone morphogenetic protein 4.	0.955
BMP6	ENSTTRP00000007731	ENSTTRP00000015103	ENSTTRP00000007731	Bone morphogenetic protein 6.	annotation not available	0.506
BMP7	BMP2	ENSTTRP00000014836	ENSTTRP00000002383	Bone morphogenetic protein 7 isoform X2.	Bone morphogenetic protein 2.	0.719
BMP7	BMP4	ENSTTRP00000014836	ENSTTRP00000008787	Bone morphogenetic protein 7 isoform X2.	Bone morphogenetic protein 4.	0.863
BMP7	DLX2	ENSTTRP00000014836	ENSTTRP00000010784	Bone morphogenetic protein 7 isoform X2.	Homeobox protein DLX-2.	0.472
BMP7	ENSTTRP00000007731	ENSTTRP00000014836	ENSTTRP00000007731	Bone morphogenetic protein 7 isoform X2.	annotation not available	0.553