STRINGSTRING
CDK1 CDK1 BTG2 BTG2 FOXN3 FOXN3 LRRC1 LRRC1 C10orf90 C10orf90 CCND1 CCND1 NME6 NME6 EZH2 EZH2 TPRA1 TPRA1 SCRIB SCRIB MUS81 MUS81 OVOL1 OVOL1 CDC6 CDC6 STK33 STK33 CDK5RAP3 CDK5RAP3 DCUN1D3 DCUN1D3 BLM BLM TAOK1 TAOK1 BUB3 BUB3 ORC1 ORC1 KNTC1 KNTC1 ENSTTRP00000014985 ENSTTRP00000014985 DLG2 DLG2 SPDL1 SPDL1 CCL2 CCL2 BTG1 BTG1 ANGEL2 ANGEL2 HECA HECA CDKN1A CDKN1A BRD7 BRD7 HUS1 HUS1 CDK2AP2 CDK2AP2 RAD9A RAD9A TAOK3 TAOK3 BRINP1 BRINP1 BMP7 BMP7 NLE1 NLE1 TICRR TICRR ZNF830 ZNF830 PKD2 PKD2 PHKG1 PHKG1 ABL1 ABL1 RAD9B RAD9B CLSPN CLSPN CDKN1B CDKN1B TOM1L2 TOM1L2 PTPN3 PTPN3 ATF2 ATF2 FBXO5 FBXO5 RFWD3 RFWD3 EME1 EME1 CHEK1 CHEK1 E2F7 E2F7 PML PML BUB1B BUB1B INTS3 INTS3 NBN NBN CTDSP1 CTDSP1 TOPBP1 TOPBP1 RBL2 RBL2 BABAM2 BABAM2 PIDD1 PIDD1 DLG1 DLG1 SDE2 SDE2 PSMG2 PSMG2 TPR TPR TOM1L1 TOM1L1 NOP53 NOP53 CHEK2 CHEK2 BRCA1 BRCA1 ZFYVE19 ZFYVE19 EME2 EME2 ZNF207 ZNF207 XPC XPC BTG3 BTG3 MAD2L1 MAD2L1 BIRC5 BIRC5 CASP2 CASP2 MAD1L1 MAD1L1 CHFR CHFR MRE11 MRE11 USP47 USP47 MEIOC MEIOC BTG4 BTG4 IK IK AURKB AURKB ZWILCH ZWILCH TIPIN TIPIN NAE1 NAE1 VPS4A VPS4A CDKN1C CDKN1C MUC1 MUC1 FAM122A FAM122A CDC73 CDC73 INIP INIP BMP4 BMP4 TRIP13 TRIP13 GPNMB GPNMB DACT1 DACT1 FBXO31 FBXO31 FZR1 FZR1 CTDSP2 CTDSP2 PRKDC PRKDC TRIM39 TRIM39 KANK2 KANK2 JADE1 JADE1 BRCC3 BRCC3 PLK5 PLK5 NABP1 NABP1 FANCD2 FANCD2 BRINP2 BRINP2 NACC2 NACC2 AVEN AVEN NABP2 NABP2 FHL1 FHL1 BRINP3 BRINP3 FBXO7 FBXO7 ZFP36L2 ZFP36L2 CTNNB1 CTNNB1 ATM ATM MTBP MTBP FZD3 FZD3 HASPIN HASPIN CTDSPL CTDSPL FOXO4 FOXO4 PLK1 PLK1 BCL2 BCL2 CRLF3 CRLF3 ABRAXAS1 ABRAXAS1 DONSON DONSON KLHL22 KLHL22 MRNIP MRNIP MSH2 MSH2 RB1 RB1 INHBA INHBA SYF2 SYF2 MIIP MIIP ZFP36L1 ZFP36L1 PLK3 PLK3 CRADD CRADD TRIM35 TRIM35 BABAM1 BABAM1 BUB1 BUB1 WAC WAC NEK11 NEK11 TTK TTK RAD17 RAD17 CHMP4C CHMP4C SLC9A3R1 SLC9A3R1 ZNF655 ZNF655 ZW10 ZW10 DTL DTL UIMC1 UIMC1 RAD21 RAD21 RBL1 RBL1 MFSD11 MFSD11 APC APC PINX1 PINX1 RINT1 RINT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDK1Cyclin-dependent kinase 1 isoform X3; Belongs to the protein kinase superfamily. (301 aa)
BTG2Protein BTG2 isoform X1. (117 aa)
FOXN3Forkhead box protein N3 isoform X4. (488 aa)
LRRC1Leucine-rich repeat-containing protein 1 isoform X1. (522 aa)
C10orf90Centrosomal protein C10orf90 homolog. (697 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
NME6Nucleoside diphosphate kinase. (194 aa)
EZH2Histone-lysine N-methyltransferase EZH2 isoform X2. (751 aa)
TPRA1Transmembrane protein adipocyte-associated 1. (361 aa)
SCRIBProtein scribble homolog. (1596 aa)
MUS81MUS81 structure-specific endonuclease subunit. (547 aa)
OVOL1Ovo like transcriptional repressor 1. (267 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (499 aa)
STK33Serine/threonine-protein kinase 33 isoform X1. (474 aa)
CDK5RAP3CDK5 regulatory subunit-associated protein 3 isoform X1. (505 aa)
DCUN1D3DCN1-like protein. (304 aa)
BLMBloom syndrome protein isoform X1. (1409 aa)
TAOK1Serine/threonine-protein kinase TAO1. (1000 aa)
BUB3Mitotic checkpoint protein BUB3 isoform X1. (328 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (828 aa)
KNTC1Kinetochore-associated protein 1. (2203 aa)
ENSTTRP00000014985annotation not available (90 aa)
DLG2Disks large homolog 2 isoform X2. (966 aa)
SPDL1Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. (603 aa)
CCL2C-C motif chemokine. (99 aa)
BTG1Protein BTG1. (121 aa)
ANGEL2Protein angel homolog 2 isoform X1. (544 aa)
HECAHeadcase protein homolog isoform X1. (287 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
BRD7Bromodomain-containing protein 7 isoform X1. (635 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (262 aa)
CDK2AP2Cyclin-dependent kinase 2-associated protein; Belongs to the CDK2AP family. (117 aa)
RAD9ARAD9 checkpoint clamp component A. (390 aa)
TAOK3Serine/threonine-protein kinase TAO3 isoform X1. (887 aa)
BRINP1BMP/retinoic acid-inducible neural-specific protein 1. (761 aa)
BMP7Bone morphogenetic protein 7 isoform X2. (431 aa)
NLE1Notchless protein homolog 1. (430 aa)
TICRRTreslin. (1890 aa)
ZNF830Zinc finger protein 830. (371 aa)
PKD2Polycystin-2 isoform X2. (975 aa)
PHKG1Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X2; Belongs to the protein kinase superfamily. (390 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (420 aa)
CLSPNClaspin. (1331 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (173 aa)
TOM1L2TOM1-like protein 2 isoform X2; Belongs to the TOM1 family. (433 aa)
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (913 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
FBXO5F-box only protein 5 isoform X1. (448 aa)
RFWD3E3 ubiquitin-protein ligase RFWD3. (724 aa)
EME1Crossover junction endonuclease EME1 isoform X1. (591 aa)
CHEK1Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily. (475 aa)
E2F7Transcription factor E2F7. (904 aa)
PMLProtein PML isoform X2. (871 aa)
BUB1BMitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform X1. (1051 aa)
INTS3Integrator complex subunit 3. (1038 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (746 aa)
CTDSP1Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1. (261 aa)
TOPBP1DNA topoisomerase 2-binding protein 1-like isoform X2. (1520 aa)
RBL2Retinoblastoma-like protein 2. (1140 aa)
BABAM2BRCA1-A complex subunit BRE. (411 aa)
PIDD1P53-induced death domain-containing protein 1. (913 aa)
DLG1Disks large homolog 1 isoform X3; Belongs to the MAGUK family. (920 aa)
SDE2Protein SDE2 homolog isoform X1. (418 aa)
PSMG2Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. Belongs to the PSMG2 family. (264 aa)
TPRNucleoprotein TPR isoform X3. (2361 aa)
TOM1L1TOM1-like protein 1; Belongs to the TOM1 family. (476 aa)
NOP53NOP53 ribosome biogenesis factor. (485 aa)
CHEK2Serine/threonine-protein kinase Chk2 isoform X2. (580 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1825 aa)
ZFYVE19abscission/NoCut checkpoint regulator. (461 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (420 aa)
ZNF207BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform X2. (492 aa)
XPCDNA repair protein complementing XP-C cells. (907 aa)
BTG3Protein BTG3 isoform X1. (219 aa)
MAD2L1Mitotic spindle assembly checkpoint protein MAD2A. (205 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (141 aa)
CASP2Caspase-2 isoform X2; Belongs to the peptidase C14A family. (452 aa)
MAD1L1Mitotic spindle assembly checkpoint protein MAD1 isoform X1. (755 aa)
CHFRE3 ubiquitin-protein ligase CHFR isoform X1. (661 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa)
USP47Ubiquitin carboxyl-terminal hydrolase 47 isoform X1; Belongs to the peptidase C19 family. (1362 aa)
MEIOCMeiosis-specific coiled-coil domain-containing protein MEIOC. (625 aa)
BTG4Protein BTG4. (225 aa)
IKProtein Red. (551 aa)
AURKBAurora kinase B isoform X4; Belongs to the protein kinase superfamily. (250 aa)
ZWILCHProtein zwilch homolog isoform X2. (585 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (297 aa)
NAE1NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (537 aa)
VPS4AVacuolar protein sorting-associated protein 4A isoform X1; Belongs to the AAA ATPase family. (433 aa)
CDKN1CCyclin-dependent kinase inhibitor 1C. (249 aa)
MUC1Mucin 1, cell surface associated. (443 aa)
FAM122AProtein FAM122A. (290 aa)
CDC73Parafibromin. (530 aa)
INIPSOSS complex subunit C isoform X1. (151 aa)
BMP4Bone morphogenetic protein 4. (407 aa)
TRIP13Pachytene checkpoint protein 2 homolog. (434 aa)
GPNMBTransmembrane glycoprotein NMB. (559 aa)
DACT1Dapper homolog 1. (745 aa)
FBXO31F-box only protein 31 isoform X1. (428 aa)
FZR1Fizzy-related protein homolog. (494 aa)
CTDSP2Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2. (241 aa)
PRKDCDNA-dependent protein kinase catalytic subunit-like isoform X2; Belongs to the PI3/PI4-kinase family. (4120 aa)
TRIM39E3 ubiquitin-protein ligase TRIM39 isoform X1. (515 aa)
KANK2KN motif and ankyrin repeat domain-containing protein 2. (739 aa)
JADE1Protein Jade-1 isoform X1. (841 aa)
BRCC3Lys-63-specific deubiquitinase BRCC36 isoform X1. (317 aa)
PLK5Polo like kinase 5. (335 aa)
NABP1SOSS complex subunit B2 isoform X1. (204 aa)
FANCD2Fanconi anemia group D2 protein isoform X2. (1450 aa)
BRINP2BMP/retinoic acid-inducible neural-specific protein 2. (784 aa)
NACC2Nucleus accumbens-associated protein 2. (418 aa)
AVENCell death regulator Aven. (353 aa)
NABP2SOSS complex subunit B1. (211 aa)
FHL1Four and a half LIM domains protein 1 isoform X1. (323 aa)
BRINP3BMP/retinoic acid-inducible neural-specific protein 3 isoform X1. (761 aa)
FBXO7LOW QUALITY PROTEIN: F-box only protein 7-like. (513 aa)
ZFP36L2mRNA decay activator protein ZFP36L2. (494 aa)
CTNNB1Catenin beta-1. (781 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3043 aa)
MTBPMdm2-binding protein isoform X2. (903 aa)
FZD3Frizzled-3 isoform X2; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
HASPINSerine/threonine-protein kinase haspin. (782 aa)
CTDSPLCTD small phosphatase-like protein isoform X4. (235 aa)
FOXO4Forkhead box O4. (511 aa)
PLK1Serine/threonine-protein kinase PLK. (602 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
CRLF3Cytokine receptor-like factor 3. (441 aa)
ABRAXAS1BRCA1-A complex subunit Abraxas isoform X1. (410 aa)
DONSONProtein downstream neighbor of Son isoform X1. (457 aa)
KLHL22Kelch-like protein 22 isoform X3. (558 aa)
MRNIPUPF0544 protein C5orf45 homolog isoform X4. (339 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (931 aa)
RB1Retinoblastoma-associated protein. (922 aa)
INHBAInhibin beta A chain. (421 aa)
SYF2pre-mRNA-splicing factor SYF2. (244 aa)
MIIPMigration and invasion-inhibitory protein isoform X2. (376 aa)
ZFP36L1mRNA decay activator protein ZFP36L1. (338 aa)
PLK3Serine/threonine-protein kinase PLK. (639 aa)
CRADDDeath domain-containing protein CRADD isoform X1. (199 aa)
TRIM35Tripartite motif-containing protein 35. (491 aa)
BABAM1BRISC and BRCA1-A complex member 1 isoform X1. (367 aa)
BUB1Mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1. (1083 aa)
WACWW domain-containing adapter protein with coiled-coil isoform X3. (635 aa)
NEK11NIMA related kinase 11. (642 aa)
TTKDual specificity protein kinase TTK isoform X1. (856 aa)
RAD17Cell cycle checkpoint protein RAD17. (683 aa)
CHMP4CCharged multivesicular body protein 4c. (237 aa)
SLC9A3R1SLC9A3 regulator 1. (359 aa)
ZNF655Zinc finger protein 655 isoform X3. (490 aa)
ZW10Centromere/kinetochore protein zw10 homolog. (730 aa)
DTLDenticleless protein homolog isoform X3. (730 aa)
UIMC1BRCA1-A complex subunit RAP80 isoform X1. (720 aa)
RAD21Double-strand-break repair protein rad21 homolog isoform X1. (630 aa)
RBL1Retinoblastoma-like protein 1 isoform X2. (1067 aa)
MFSD11UNC93-like protein MFSD11. (449 aa)
APCAdenomatous polyposis coli protein isoform X2. (2845 aa)
PINX1PIN2/TERF1-interacting telomerase inhibitor 1. (312 aa)
RINT1RAD50-interacting protein 1 isoform X1. (792 aa)
Your Current Organism:
Tursiops truncatus
NCBI taxonomy Id: 9739
Other names: Atlantic bottlenose dolphin, T. truncatus, bottle-nosed dolphin, common bottlenose dolphin
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